Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins

The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hesham ElAbd [verfasserIn] Petra Bacher [verfasserIn] Andreas Tholey [verfasserIn] Tobias L. Lenz [verfasserIn] Andre Franke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	HLA-II & autoimmunity immunogenicitiy TCR - T cell receptor mass-spectrometry (MS) based immunopeptidomics neoantigen immunotherapy

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2023.1107266

Katalog-ID:	DOAJ088944875

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520			\|a The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies.
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allfieldsSound	10.3389/fimmu.2023.1107266 doi (DE-627)DOAJ088944875 (DE-599)DOAJ56154be4d93845189cf476223e6cf212 DE-627 ger DE-627 rakwb eng RC581-607 Hesham ElAbd verfasserin aut Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies. HLA-II & autoimmunity immunogenicitiy TCR - T cell receptor mass-spectrometry (MS) based immunopeptidomics neoantigen immunotherapy Immunologic diseases. Allergy Petra Bacher verfasserin aut Petra Bacher verfasserin aut Andreas Tholey verfasserin aut Tobias L. Lenz verfasserin aut Andre Franke verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1107266 kostenfrei https://doaj.org/article/56154be4d93845189cf476223e6cf212 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107266/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
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topic_facet	HLA-II & autoimmunity immunogenicitiy TCR - T cell receptor mass-spectrometry (MS) based immunopeptidomics neoantigen immunotherapy Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
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callnumber-first	R - Medicine
author	Hesham ElAbd
spellingShingle	Hesham ElAbd misc RC581-607 misc HLA-II & autoimmunity misc immunogenicitiy misc TCR - T cell receptor misc mass-spectrometry (MS) based immunopeptidomics misc neoantigen misc immunotherapy misc Immunologic diseases. Allergy Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins
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topic_title	RC581-607 Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins HLA-II & autoimmunity immunogenicitiy TCR - T cell receptor mass-spectrometry (MS) based immunopeptidomics neoantigen immunotherapy
topic	misc RC581-607 misc HLA-II & autoimmunity misc immunogenicitiy misc TCR - T cell receptor misc mass-spectrometry (MS) based immunopeptidomics misc neoantigen misc immunotherapy misc Immunologic diseases. Allergy
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title	Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins
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title_full	Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins
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title_sort	challenges and opportunities in analyzing and modeling peptide presentation by hla-ii proteins
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title_auth	Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins
abstract	The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies.
abstractGer	The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies.
abstract_unstemmed	The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins in vivo, as a whole being referred to as the immunopeptidome, has therefore gathered increasing attention for different reasons. For example, identifying neoepitopes for cancer immunotherapy, vaccine development against infectious pathogens, or elucidating the role of HLA in autoimmunity. Despite the tremendous progress made during the last decade in these areas, several questions remain unanswered. In this perspective, we highlight five remaining key challenges in the analysis of peptide presentation and T cell immunogenicity and discuss potential solutions to these problems. We believe that addressing these questions would not only improve our understanding of disease etiology but will also have a direct translational impact in terms of engineering better vaccines and in developing more potent immunotherapies.
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title_short	Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins
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