The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy
Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnet...
Ausführliche Beschreibung
Autor*in: |
Dongsheng Li [verfasserIn] Yue Fan [verfasserIn] Miaomiao Liu [verfasserIn] SiLin Huang [verfasserIn] Shasha Wang [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Arabian Journal of Chemistry - Elsevier, 2016, 16(2023), 7, Seite 104758- |
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Übergeordnetes Werk: |
volume:16 ; year:2023 ; number:7 ; pages:104758- |
Links: |
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DOI / URN: |
10.1016/j.arabjc.2023.104758 |
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Katalog-ID: |
DOAJ089103653 |
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245 | 1 | 4 | |a The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy |
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520 | |a Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. | ||
650 | 4 | |a Gastric cancer | |
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700 | 0 | |a Shasha Wang |e verfasserin |4 aut | |
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10.1016/j.arabjc.2023.104758 doi (DE-627)DOAJ089103653 (DE-599)DOAJ1891e51adc65479380b68163483747a6 DE-627 ger DE-627 rakwb eng QD1-999 Dongsheng Li verfasserin aut The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. Gastric cancer Photothermal therapy Chemotherapy Magnetic nanoparticle Cisplatin Chemistry Yue Fan verfasserin aut Miaomiao Liu verfasserin aut SiLin Huang verfasserin aut Shasha Wang verfasserin aut In Arabian Journal of Chemistry Elsevier, 2016 16(2023), 7, Seite 104758- (DE-627)609401564 (DE-600)2515214-2 18785352 nnns volume:16 year:2023 number:7 pages:104758- https://doi.org/10.1016/j.arabjc.2023.104758 kostenfrei https://doaj.org/article/1891e51adc65479380b68163483747a6 kostenfrei http://www.sciencedirect.com/science/article/pii/S1878535223002204 kostenfrei https://doaj.org/toc/1878-5352 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 104758- |
spelling |
10.1016/j.arabjc.2023.104758 doi (DE-627)DOAJ089103653 (DE-599)DOAJ1891e51adc65479380b68163483747a6 DE-627 ger DE-627 rakwb eng QD1-999 Dongsheng Li verfasserin aut The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. Gastric cancer Photothermal therapy Chemotherapy Magnetic nanoparticle Cisplatin Chemistry Yue Fan verfasserin aut Miaomiao Liu verfasserin aut SiLin Huang verfasserin aut Shasha Wang verfasserin aut In Arabian Journal of Chemistry Elsevier, 2016 16(2023), 7, Seite 104758- (DE-627)609401564 (DE-600)2515214-2 18785352 nnns volume:16 year:2023 number:7 pages:104758- https://doi.org/10.1016/j.arabjc.2023.104758 kostenfrei https://doaj.org/article/1891e51adc65479380b68163483747a6 kostenfrei http://www.sciencedirect.com/science/article/pii/S1878535223002204 kostenfrei https://doaj.org/toc/1878-5352 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 104758- |
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10.1016/j.arabjc.2023.104758 doi (DE-627)DOAJ089103653 (DE-599)DOAJ1891e51adc65479380b68163483747a6 DE-627 ger DE-627 rakwb eng QD1-999 Dongsheng Li verfasserin aut The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. Gastric cancer Photothermal therapy Chemotherapy Magnetic nanoparticle Cisplatin Chemistry Yue Fan verfasserin aut Miaomiao Liu verfasserin aut SiLin Huang verfasserin aut Shasha Wang verfasserin aut In Arabian Journal of Chemistry Elsevier, 2016 16(2023), 7, Seite 104758- (DE-627)609401564 (DE-600)2515214-2 18785352 nnns volume:16 year:2023 number:7 pages:104758- https://doi.org/10.1016/j.arabjc.2023.104758 kostenfrei https://doaj.org/article/1891e51adc65479380b68163483747a6 kostenfrei http://www.sciencedirect.com/science/article/pii/S1878535223002204 kostenfrei https://doaj.org/toc/1878-5352 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 104758- |
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10.1016/j.arabjc.2023.104758 doi (DE-627)DOAJ089103653 (DE-599)DOAJ1891e51adc65479380b68163483747a6 DE-627 ger DE-627 rakwb eng QD1-999 Dongsheng Li verfasserin aut The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. Gastric cancer Photothermal therapy Chemotherapy Magnetic nanoparticle Cisplatin Chemistry Yue Fan verfasserin aut Miaomiao Liu verfasserin aut SiLin Huang verfasserin aut Shasha Wang verfasserin aut In Arabian Journal of Chemistry Elsevier, 2016 16(2023), 7, Seite 104758- (DE-627)609401564 (DE-600)2515214-2 18785352 nnns volume:16 year:2023 number:7 pages:104758- https://doi.org/10.1016/j.arabjc.2023.104758 kostenfrei https://doaj.org/article/1891e51adc65479380b68163483747a6 kostenfrei http://www.sciencedirect.com/science/article/pii/S1878535223002204 kostenfrei https://doaj.org/toc/1878-5352 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 104758- |
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10.1016/j.arabjc.2023.104758 doi (DE-627)DOAJ089103653 (DE-599)DOAJ1891e51adc65479380b68163483747a6 DE-627 ger DE-627 rakwb eng QD1-999 Dongsheng Li verfasserin aut The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. Gastric cancer Photothermal therapy Chemotherapy Magnetic nanoparticle Cisplatin Chemistry Yue Fan verfasserin aut Miaomiao Liu verfasserin aut SiLin Huang verfasserin aut Shasha Wang verfasserin aut In Arabian Journal of Chemistry Elsevier, 2016 16(2023), 7, Seite 104758- (DE-627)609401564 (DE-600)2515214-2 18785352 nnns volume:16 year:2023 number:7 pages:104758- https://doi.org/10.1016/j.arabjc.2023.104758 kostenfrei https://doaj.org/article/1891e51adc65479380b68163483747a6 kostenfrei http://www.sciencedirect.com/science/article/pii/S1878535223002204 kostenfrei https://doaj.org/toc/1878-5352 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 104758- |
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Dongsheng Li misc QD1-999 misc Gastric cancer misc Photothermal therapy misc Chemotherapy misc Magnetic nanoparticle misc Cisplatin misc Chemistry The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy |
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QD1-999 The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy Gastric cancer Photothermal therapy Chemotherapy Magnetic nanoparticle Cisplatin |
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effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy |
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The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy |
abstract |
Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. |
abstractGer |
Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. |
abstract_unstemmed |
Because magnetic nanoparticles (NPs) have the ability to combine different therapies such as drug delivery and photothermal therapy (PTT) along with reducing cancer drug resistance, their use in cancer treatment is considerable. For this purpose, we developed albumin-perfluorohexane/cisplatin-magnetite NPs (A-PFH/C-MNPs) by hydrothermal method. Then, the physicochemical properties of the MNPs and A-PFH/C-MNPs were investigated by SEM, TEM, XRD, and FTIR. In the following, drug release at different pH and A-PFH/C-MNPs thermal reactions were assessed. The toxicity of different drug formulations against advanced gastric cancer (AGS) and mouse fibroblast (3 T3) cells were assessed by MTT assay, followed by flow cytometry and real time PCR on AGS cells. The results determined that A-PFH/C-MNPs (∼142 nm) with a relatively uniform distribution, in addition to increasing the loading capacity up to 60%, raise the PFH release by increasing the temperature from 37 °C to 45 °C. Also, in vitro outcomes exhibited higher toxicity of A-PFH/C-MNPs + PTT compared to free C against AGS cells. Whereas, the toxicity of A-C-MNPs and A-PFH/C-MNPs + PTT on 3 T3 cells as normal cells was much lower compared to the cancer cells. The mechanism of cytotoxicity indicates that A-PFH/C-MNPs + PTT significantly increase apoptosis by inducing expression of TNF-α and Bax mRNA compared to A-C-MNPs. Overall, A-PFH/C-MNPs + PTT provided a promising platform in anticancer activity by increasing drug loading capacity and combined chemotherapy and PTT. |
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The effect of using albumin-perfluorohexane/cisplatin-magnetite nanoparticles produced by hydrothermal method against gastric cancer cells through combination therapy |
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