Dynamics and length distributions of microtubules with a multistep catastrophe mechanism

Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two r...
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Autor*in:	Felix Schwietert [verfasserIn] Lina Heydenreich [verfasserIn] Jan Kierfeld [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	microtubule dynamic instability catastrophe multistep

Übergeordnetes Werk:	In: New Journal of Physics - IOP Publishing, 2003, 25(2023), 1, p 013017
Übergeordnetes Werk:	volume:25 ; year:2023 ; number:1, p 013017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1088/1367-2630/acb07b

Katalog-ID:	DOAJ089157680

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520			\|a Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations.
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allfields	10.1088/1367-2630/acb07b doi (DE-627)DOAJ089157680 (DE-599)DOAJ98a3904b0a83439cb5345e60c15efe61 DE-627 ger DE-627 rakwb eng QC1-999 Felix Schwietert verfasserin aut Dynamics and length distributions of microtubules with a multistep catastrophe mechanism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations. microtubule dynamic instability catastrophe multistep Science Q Physics Lina Heydenreich verfasserin aut Jan Kierfeld verfasserin aut In New Journal of Physics IOP Publishing, 2003 25(2023), 1, p 013017 (DE-627)265510562 (DE-600)1464444-7 13672630 nnns volume:25 year:2023 number:1, p 013017 https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/article/98a3904b0a83439cb5345e60c15efe61 kostenfrei https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/toc/1367-2630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_2884 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1, p 013017
spelling	10.1088/1367-2630/acb07b doi (DE-627)DOAJ089157680 (DE-599)DOAJ98a3904b0a83439cb5345e60c15efe61 DE-627 ger DE-627 rakwb eng QC1-999 Felix Schwietert verfasserin aut Dynamics and length distributions of microtubules with a multistep catastrophe mechanism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations. microtubule dynamic instability catastrophe multistep Science Q Physics Lina Heydenreich verfasserin aut Jan Kierfeld verfasserin aut In New Journal of Physics IOP Publishing, 2003 25(2023), 1, p 013017 (DE-627)265510562 (DE-600)1464444-7 13672630 nnns volume:25 year:2023 number:1, p 013017 https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/article/98a3904b0a83439cb5345e60c15efe61 kostenfrei https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/toc/1367-2630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_2884 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1, p 013017
allfields_unstemmed	10.1088/1367-2630/acb07b doi (DE-627)DOAJ089157680 (DE-599)DOAJ98a3904b0a83439cb5345e60c15efe61 DE-627 ger DE-627 rakwb eng QC1-999 Felix Schwietert verfasserin aut Dynamics and length distributions of microtubules with a multistep catastrophe mechanism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations. microtubule dynamic instability catastrophe multistep Science Q Physics Lina Heydenreich verfasserin aut Jan Kierfeld verfasserin aut In New Journal of Physics IOP Publishing, 2003 25(2023), 1, p 013017 (DE-627)265510562 (DE-600)1464444-7 13672630 nnns volume:25 year:2023 number:1, p 013017 https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/article/98a3904b0a83439cb5345e60c15efe61 kostenfrei https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/toc/1367-2630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_2884 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1, p 013017
allfieldsGer	10.1088/1367-2630/acb07b doi (DE-627)DOAJ089157680 (DE-599)DOAJ98a3904b0a83439cb5345e60c15efe61 DE-627 ger DE-627 rakwb eng QC1-999 Felix Schwietert verfasserin aut Dynamics and length distributions of microtubules with a multistep catastrophe mechanism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations. microtubule dynamic instability catastrophe multistep Science Q Physics Lina Heydenreich verfasserin aut Jan Kierfeld verfasserin aut In New Journal of Physics IOP Publishing, 2003 25(2023), 1, p 013017 (DE-627)265510562 (DE-600)1464444-7 13672630 nnns volume:25 year:2023 number:1, p 013017 https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/article/98a3904b0a83439cb5345e60c15efe61 kostenfrei https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/toc/1367-2630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_2884 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1, p 013017
allfieldsSound	10.1088/1367-2630/acb07b doi (DE-627)DOAJ089157680 (DE-599)DOAJ98a3904b0a83439cb5345e60c15efe61 DE-627 ger DE-627 rakwb eng QC1-999 Felix Schwietert verfasserin aut Dynamics and length distributions of microtubules with a multistep catastrophe mechanism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations. microtubule dynamic instability catastrophe multistep Science Q Physics Lina Heydenreich verfasserin aut Jan Kierfeld verfasserin aut In New Journal of Physics IOP Publishing, 2003 25(2023), 1, p 013017 (DE-627)265510562 (DE-600)1464444-7 13672630 nnns volume:25 year:2023 number:1, p 013017 https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/article/98a3904b0a83439cb5345e60c15efe61 kostenfrei https://doi.org/10.1088/1367-2630/acb07b kostenfrei https://doaj.org/toc/1367-2630 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_2884 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2023 1, p 013017
language	English
source	In New Journal of Physics 25(2023), 1, p 013017 volume:25 year:2023 number:1, p 013017
sourceStr	In New Journal of Physics 25(2023), 1, p 013017 volume:25 year:2023 number:1, p 013017
format_phy_str_mv	Article
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topic_facet	microtubule dynamic instability catastrophe multistep Science Q Physics
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container_title	New Journal of Physics
authorswithroles_txt_mv	Felix Schwietert @@aut@@ Lina Heydenreich @@aut@@ Jan Kierfeld @@aut@@
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callnumber-first	Q - Science
author	Felix Schwietert
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topic_title	QC1-999 Dynamics and length distributions of microtubules with a multistep catastrophe mechanism microtubule dynamic instability catastrophe multistep
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title	Dynamics and length distributions of microtubules with a multistep catastrophe mechanism
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title_full	Dynamics and length distributions of microtubules with a multistep catastrophe mechanism
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title_sort	dynamics and length distributions of microtubules with a multistep catastrophe mechanism
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title_auth	Dynamics and length distributions of microtubules with a multistep catastrophe mechanism
abstract	Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations.
abstractGer	Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations.
abstract_unstemmed	Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has on the distribution of MT lengths in the two regimes of bounded and unbounded growth. We show that in the former case, the steady state length distribution is non-exponential and has a lighter tail if multiple steps are required to undergo a catastrophe. If rescue events are possible, we detect a maximum in the distribution, i.e. the MT has a most probable length greater than zero. In the regime of unbounded growth, the length distribution converges to a Gaussian distribution whose variance decreases with the number of catastrophe steps. We extend our work by applying the multistep catastrophe model to MTs that grow against an opposing force and to MTs that are confined between two rigid walls. We determine critical forces below which the MT is in the bounded regime, and show that the multistep characteristics of the length distribution are largely lost if the growth of an MT in the unbounded regime is restricted by a rigid wall. All results are verified by stochastic simulations.
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title_short	Dynamics and length distributions of microtubules with a multistep catastrophe mechanism
url	https://doi.org/10.1088/1367-2630/acb07b https://doaj.org/article/98a3904b0a83439cb5345e60c15efe61 https://doaj.org/toc/1367-2630
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Dynamics and length distributions of microtubules with a multistep catastrophe mechanism

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