Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey

Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by plants as a self-defense against insects. After bioactivation in the liver, some PAs can cause acute or chronic toxicity in humans. The aim of this study was to determine the presence of PAs in 121 samples of monofloral and multiflo...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Paola Roncada [verfasserIn] Gloria Isani [verfasserIn] Mariantonietta Peloso [verfasserIn] Thomas Dalmonte [verfasserIn] Stefania Bonan [verfasserIn] Elisabetta Caprai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	honey Boraginaceae pyrrolizidine alkaloids echimidine health risk assessment

Übergeordnetes Werk:	In: International Journal of Environmental Research and Public Health - MDPI AG, 2005, 20(2023), 5410, p 5410
Übergeordnetes Werk:	volume:20 ; year:2023 ; number:5410, p 5410

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijerph20075410

Katalog-ID:	DOAJ089377621

Internformat


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allfieldsSound	10.3390/ijerph20075410 doi (DE-627)DOAJ089377621 (DE-599)DOAJe3f59e6b5d3d446f874a3234f634d35c DE-627 ger DE-627 rakwb eng Paola Roncada verfasserin aut Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by plants as a self-defense against insects. After bioactivation in the liver, some PAs can cause acute or chronic toxicity in humans. The aim of this study was to determine the presence of PAs in 121 samples of monofloral and multifloral honey from three different Italian regions (Friuli-Venezia Giulia, Marche and Calabria) to meet the European Food Safety Authority (EFSA) suggestion. An in-house liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was validated according to European Union Reference Laboratory (EURL) performance criteria. This method allowed the detection and quantification of 35 PAs. Of the 121 honey samples, 38 (31%), mostly from Calabria, contained PAs. The total content of the PAs ranged from 0.9 µg/kg to 33.1 µg/kg. In particular, echimidine was the most prevalent PA. A rapid human exposure assessment to PAs in honey and a risk characterization was performed using the EFSA RACE tool. The assessment highlighted a potential health concern only for toddlers who frequently consume elevated quantities of honey. This study showed a low presence of PAs in Italian honey; however, the importance of continuously monitoring these compounds is stressed, along with the suggestion that the relevant authorities establish maximum limits to guarantee support for producers and consumer safety. honey Boraginaceae pyrrolizidine alkaloids echimidine health risk assessment Medicine R Gloria Isani verfasserin aut Mariantonietta Peloso verfasserin aut Thomas Dalmonte verfasserin aut Stefania Bonan verfasserin aut Elisabetta Caprai verfasserin aut In International Journal of Environmental Research and Public Health MDPI AG, 2005 20(2023), 5410, p 5410 (DE-627)477992463 (DE-600)2175195-X 16604601 nnns volume:20 year:2023 number:5410, p 5410 https://doi.org/10.3390/ijerph20075410 kostenfrei https://doaj.org/article/e3f59e6b5d3d446f874a3234f634d35c kostenfrei https://www.mdpi.com/1660-4601/20/7/5410 kostenfrei https://doaj.org/toc/1661-7827 Journal toc kostenfrei https://doaj.org/toc/1660-4601 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 5410, p 5410
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author	Paola Roncada
spellingShingle	Paola Roncada misc honey misc Boraginaceae misc pyrrolizidine alkaloids misc echimidine misc health risk assessment misc Medicine misc R Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey
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topic_title	Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey honey Boraginaceae pyrrolizidine alkaloids echimidine health risk assessment
topic	misc honey misc Boraginaceae misc pyrrolizidine alkaloids misc echimidine misc health risk assessment misc Medicine misc R
topic_unstemmed	misc honey misc Boraginaceae misc pyrrolizidine alkaloids misc echimidine misc health risk assessment misc Medicine misc R
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title	Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey
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title_sort	pyrrolizidine alkaloids from monofloral and multifloral italian honey
title_auth	Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey
abstract	Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by plants as a self-defense against insects. After bioactivation in the liver, some PAs can cause acute or chronic toxicity in humans. The aim of this study was to determine the presence of PAs in 121 samples of monofloral and multifloral honey from three different Italian regions (Friuli-Venezia Giulia, Marche and Calabria) to meet the European Food Safety Authority (EFSA) suggestion. An in-house liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was validated according to European Union Reference Laboratory (EURL) performance criteria. This method allowed the detection and quantification of 35 PAs. Of the 121 honey samples, 38 (31%), mostly from Calabria, contained PAs. The total content of the PAs ranged from 0.9 µg/kg to 33.1 µg/kg. In particular, echimidine was the most prevalent PA. A rapid human exposure assessment to PAs in honey and a risk characterization was performed using the EFSA RACE tool. The assessment highlighted a potential health concern only for toddlers who frequently consume elevated quantities of honey. This study showed a low presence of PAs in Italian honey; however, the importance of continuously monitoring these compounds is stressed, along with the suggestion that the relevant authorities establish maximum limits to guarantee support for producers and consumer safety.
abstractGer	Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by plants as a self-defense against insects. After bioactivation in the liver, some PAs can cause acute or chronic toxicity in humans. The aim of this study was to determine the presence of PAs in 121 samples of monofloral and multifloral honey from three different Italian regions (Friuli-Venezia Giulia, Marche and Calabria) to meet the European Food Safety Authority (EFSA) suggestion. An in-house liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was validated according to European Union Reference Laboratory (EURL) performance criteria. This method allowed the detection and quantification of 35 PAs. Of the 121 honey samples, 38 (31%), mostly from Calabria, contained PAs. The total content of the PAs ranged from 0.9 µg/kg to 33.1 µg/kg. In particular, echimidine was the most prevalent PA. A rapid human exposure assessment to PAs in honey and a risk characterization was performed using the EFSA RACE tool. The assessment highlighted a potential health concern only for toddlers who frequently consume elevated quantities of honey. This study showed a low presence of PAs in Italian honey; however, the importance of continuously monitoring these compounds is stressed, along with the suggestion that the relevant authorities establish maximum limits to guarantee support for producers and consumer safety.
abstract_unstemmed	Pyrrolizidine alkaloids (PAs) are secondary metabolites produced by plants as a self-defense against insects. After bioactivation in the liver, some PAs can cause acute or chronic toxicity in humans. The aim of this study was to determine the presence of PAs in 121 samples of monofloral and multifloral honey from three different Italian regions (Friuli-Venezia Giulia, Marche and Calabria) to meet the European Food Safety Authority (EFSA) suggestion. An in-house liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was validated according to European Union Reference Laboratory (EURL) performance criteria. This method allowed the detection and quantification of 35 PAs. Of the 121 honey samples, 38 (31%), mostly from Calabria, contained PAs. The total content of the PAs ranged from 0.9 µg/kg to 33.1 µg/kg. In particular, echimidine was the most prevalent PA. A rapid human exposure assessment to PAs in honey and a risk characterization was performed using the EFSA RACE tool. The assessment highlighted a potential health concern only for toddlers who frequently consume elevated quantities of honey. This study showed a low presence of PAs in Italian honey; however, the importance of continuously monitoring these compounds is stressed, along with the suggestion that the relevant authorities establish maximum limits to guarantee support for producers and consumer safety.
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title_short	Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey
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author2	Gloria Isani Mariantonietta Peloso Thomas Dalmonte Stefania Bonan Elisabetta Caprai
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Pyrrolizidine Alkaloids from Monofloral and Multifloral Italian Honey

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