Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment

Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially explained by the characteristics of the tumor...
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Autor*in:	Giulia Milardi [verfasserIn] Ana Lleo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	tumor microenvironment primary liver cancer hepatocellular carcinoma cholangiocarcinoma B lymphocytes

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 7, p 2182
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:7, p 2182

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15072182

Katalog-ID:	DOAJ08939187X

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allfieldsSound	10.3390/cancers15072182 doi (DE-627)DOAJ08939187X (DE-599)DOAJbd5b0d4ba1324b85895180eaaec36f54 DE-627 ger DE-627 rakwb eng RC254-282 Giulia Milardi verfasserin aut Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially explained by the characteristics of the tumor microenvironment (TME), where adaptive and innate immune system cells are the main components. Pioneering studies of primary liver cancers revealed that tumor-infiltrating immune cells and their dynamic interaction with cancer cells significantly impacted carcinogenesis, playing an important role in cancer immune evasion and responses to immunotherapy treatment. In particular, B cells may play a prominent role and have a controversial function in the TME. In this work, we highlight the effect of B lymphocytes as tumor infiltrates in relation to primary liver cancers and their potential prognostic value. We also present the key pathways underlying B-cell interactions within the TME, as well as the way that a comprehensive characterization of B-cell biology can be exploited to develop novel immune-based therapeutic approaches. tumor microenvironment primary liver cancer hepatocellular carcinoma cholangiocarcinoma B lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ana Lleo verfasserin aut In Cancers MDPI AG, 2010 15(2023), 7, p 2182 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:7, p 2182 https://doi.org/10.3390/cancers15072182 kostenfrei https://doaj.org/article/bd5b0d4ba1324b85895180eaaec36f54 kostenfrei https://www.mdpi.com/2072-6694/15/7/2182 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 7, p 2182
language	English
source	In Cancers 15(2023), 7, p 2182 volume:15 year:2023 number:7, p 2182
sourceStr	In Cancers 15(2023), 7, p 2182 volume:15 year:2023 number:7, p 2182
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topic_facet	tumor microenvironment primary liver cancer hepatocellular carcinoma cholangiocarcinoma B lymphocytes Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
authorswithroles_txt_mv	Giulia Milardi @@aut@@ Ana Lleo @@aut@@
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callnumber-first	R - Medicine
author	Giulia Milardi
spellingShingle	Giulia Milardi misc RC254-282 misc tumor microenvironment misc primary liver cancer misc hepatocellular carcinoma misc cholangiocarcinoma misc B lymphocytes misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment
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topic_title	RC254-282 Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment tumor microenvironment primary liver cancer hepatocellular carcinoma cholangiocarcinoma B lymphocytes
topic	misc RC254-282 misc tumor microenvironment misc primary liver cancer misc hepatocellular carcinoma misc cholangiocarcinoma misc B lymphocytes misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc tumor microenvironment misc primary liver cancer misc hepatocellular carcinoma misc cholangiocarcinoma misc B lymphocytes misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc tumor microenvironment misc primary liver cancer misc hepatocellular carcinoma misc cholangiocarcinoma misc B lymphocytes misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment
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title_sort	tumor-infiltrating b lymphocytes: promising immunotherapeutic targets for primary liver cancer treatment
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title_auth	Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment
abstract	Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially explained by the characteristics of the tumor microenvironment (TME), where adaptive and innate immune system cells are the main components. Pioneering studies of primary liver cancers revealed that tumor-infiltrating immune cells and their dynamic interaction with cancer cells significantly impacted carcinogenesis, playing an important role in cancer immune evasion and responses to immunotherapy treatment. In particular, B cells may play a prominent role and have a controversial function in the TME. In this work, we highlight the effect of B lymphocytes as tumor infiltrates in relation to primary liver cancers and their potential prognostic value. We also present the key pathways underlying B-cell interactions within the TME, as well as the way that a comprehensive characterization of B-cell biology can be exploited to develop novel immune-based therapeutic approaches.
abstractGer	Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially explained by the characteristics of the tumor microenvironment (TME), where adaptive and innate immune system cells are the main components. Pioneering studies of primary liver cancers revealed that tumor-infiltrating immune cells and their dynamic interaction with cancer cells significantly impacted carcinogenesis, playing an important role in cancer immune evasion and responses to immunotherapy treatment. In particular, B cells may play a prominent role and have a controversial function in the TME. In this work, we highlight the effect of B lymphocytes as tumor infiltrates in relation to primary liver cancers and their potential prognostic value. We also present the key pathways underlying B-cell interactions within the TME, as well as the way that a comprehensive characterization of B-cell biology can be exploited to develop novel immune-based therapeutic approaches.
abstract_unstemmed	Hepatocellular carcinoma and cholangiocarcinoma are the fourth most lethal primary cancers worldwide. Therefore, there is an urgent need for therapeutic strategies, including immune cell targeting therapies. The heterogeneity of liver cancer is partially explained by the characteristics of the tumor microenvironment (TME), where adaptive and innate immune system cells are the main components. Pioneering studies of primary liver cancers revealed that tumor-infiltrating immune cells and their dynamic interaction with cancer cells significantly impacted carcinogenesis, playing an important role in cancer immune evasion and responses to immunotherapy treatment. In particular, B cells may play a prominent role and have a controversial function in the TME. In this work, we highlight the effect of B lymphocytes as tumor infiltrates in relation to primary liver cancers and their potential prognostic value. We also present the key pathways underlying B-cell interactions within the TME, as well as the way that a comprehensive characterization of B-cell biology can be exploited to develop novel immune-based therapeutic approaches.
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title_short	Tumor-Infiltrating B Lymphocytes: Promising Immunotherapeutic Targets for Primary Liver Cancer Treatment
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