Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine

Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the rapid development of resistance to conventional chemotherapy...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Giulia Spagnol [verfasserIn] Francesca Sensi [verfasserIn] Orazio De Tommasi [verfasserIn] Matteo Marchetti [verfasserIn] Giulio Bonaldo [verfasserIn] Livia Xhindoli [verfasserIn] Marco Noventa [verfasserIn] Marco Agostini [verfasserIn] Roberto Tozzi [verfasserIn] Carlo Saccardi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	ovarian cancer organoids tumor microenvironment extracellular matrix drug screening

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 7, p 2059
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:7, p 2059

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15072059

Katalog-ID:	DOAJ089393104

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allfields	10.3390/cancers15072059 doi (DE-627)DOAJ089393104 (DE-599)DOAJef4f20d7064b4f1a87c771a8c46bd6ac DE-627 ger DE-627 rakwb eng RC254-282 Giulia Spagnol verfasserin aut Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the rapid development of resistance to conventional chemotherapy. In recent years, in order to overcome these problems, targeted therapies have been introduced in various types of tumors, including gynecological cancer. However, the lack of predictive biomarkers showing different clinical benefits limits the effectiveness of these therapies. This requires the development of preclinical models that can replicate the histological and molecular characteristics of OC subtypes. In this scenario, organoids become an important preclinical model for personalized medicine. In fact, patient-derived organoids (PDO) recapture tumor heterogeneity with the possibility of performing drug screening. However, to best reproduce the patient’s characteristics, it is necessary to develop a specific extracellular matrix (ECM) and introduce a tumor microenvironment (TME), which both represent an actual object of study to improve drug screening, particularly when used in targeted therapy and immunotherapy to guide therapeutic decisions. In this review, we summarize the current state of the art for the screening of PDOs, ECM, TME, and drugs in the setting of OC, as well as discussing the clinical implications and future perspectives for the research of OC organoids. ovarian cancer organoids tumor microenvironment extracellular matrix drug screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens Francesca Sensi verfasserin aut Orazio De Tommasi verfasserin aut Matteo Marchetti verfasserin aut Giulio Bonaldo verfasserin aut Livia Xhindoli verfasserin aut Marco Noventa verfasserin aut Marco Agostini verfasserin aut Roberto Tozzi verfasserin aut Carlo Saccardi verfasserin aut In Cancers MDPI AG, 2010 15(2023), 7, p 2059 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:7, p 2059 https://doi.org/10.3390/cancers15072059 kostenfrei https://doaj.org/article/ef4f20d7064b4f1a87c771a8c46bd6ac kostenfrei https://www.mdpi.com/2072-6694/15/7/2059 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 7, p 2059
spelling	10.3390/cancers15072059 doi (DE-627)DOAJ089393104 (DE-599)DOAJef4f20d7064b4f1a87c771a8c46bd6ac DE-627 ger DE-627 rakwb eng RC254-282 Giulia Spagnol verfasserin aut Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the rapid development of resistance to conventional chemotherapy. In recent years, in order to overcome these problems, targeted therapies have been introduced in various types of tumors, including gynecological cancer. However, the lack of predictive biomarkers showing different clinical benefits limits the effectiveness of these therapies. This requires the development of preclinical models that can replicate the histological and molecular characteristics of OC subtypes. In this scenario, organoids become an important preclinical model for personalized medicine. In fact, patient-derived organoids (PDO) recapture tumor heterogeneity with the possibility of performing drug screening. However, to best reproduce the patient’s characteristics, it is necessary to develop a specific extracellular matrix (ECM) and introduce a tumor microenvironment (TME), which both represent an actual object of study to improve drug screening, particularly when used in targeted therapy and immunotherapy to guide therapeutic decisions. In this review, we summarize the current state of the art for the screening of PDOs, ECM, TME, and drugs in the setting of OC, as well as discussing the clinical implications and future perspectives for the research of OC organoids. ovarian cancer organoids tumor microenvironment extracellular matrix drug screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens Francesca Sensi verfasserin aut Orazio De Tommasi verfasserin aut Matteo Marchetti verfasserin aut Giulio Bonaldo verfasserin aut Livia Xhindoli verfasserin aut Marco Noventa verfasserin aut Marco Agostini verfasserin aut Roberto Tozzi verfasserin aut Carlo Saccardi verfasserin aut In Cancers MDPI AG, 2010 15(2023), 7, p 2059 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:7, p 2059 https://doi.org/10.3390/cancers15072059 kostenfrei https://doaj.org/article/ef4f20d7064b4f1a87c771a8c46bd6ac kostenfrei https://www.mdpi.com/2072-6694/15/7/2059 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 7, p 2059
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allfieldsSound	10.3390/cancers15072059 doi (DE-627)DOAJ089393104 (DE-599)DOAJef4f20d7064b4f1a87c771a8c46bd6ac DE-627 ger DE-627 rakwb eng RC254-282 Giulia Spagnol verfasserin aut Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the rapid development of resistance to conventional chemotherapy. In recent years, in order to overcome these problems, targeted therapies have been introduced in various types of tumors, including gynecological cancer. However, the lack of predictive biomarkers showing different clinical benefits limits the effectiveness of these therapies. This requires the development of preclinical models that can replicate the histological and molecular characteristics of OC subtypes. In this scenario, organoids become an important preclinical model for personalized medicine. In fact, patient-derived organoids (PDO) recapture tumor heterogeneity with the possibility of performing drug screening. However, to best reproduce the patient’s characteristics, it is necessary to develop a specific extracellular matrix (ECM) and introduce a tumor microenvironment (TME), which both represent an actual object of study to improve drug screening, particularly when used in targeted therapy and immunotherapy to guide therapeutic decisions. In this review, we summarize the current state of the art for the screening of PDOs, ECM, TME, and drugs in the setting of OC, as well as discussing the clinical implications and future perspectives for the research of OC organoids. ovarian cancer organoids tumor microenvironment extracellular matrix drug screening Neoplasms. Tumors. Oncology. Including cancer and carcinogens Francesca Sensi verfasserin aut Orazio De Tommasi verfasserin aut Matteo Marchetti verfasserin aut Giulio Bonaldo verfasserin aut Livia Xhindoli verfasserin aut Marco Noventa verfasserin aut Marco Agostini verfasserin aut Roberto Tozzi verfasserin aut Carlo Saccardi verfasserin aut In Cancers MDPI AG, 2010 15(2023), 7, p 2059 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:7, p 2059 https://doi.org/10.3390/cancers15072059 kostenfrei https://doaj.org/article/ef4f20d7064b4f1a87c771a8c46bd6ac kostenfrei https://www.mdpi.com/2072-6694/15/7/2059 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 7, p 2059
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authorswithroles_txt_mv	Giulia Spagnol @@aut@@ Francesca Sensi @@aut@@ Orazio De Tommasi @@aut@@ Matteo Marchetti @@aut@@ Giulio Bonaldo @@aut@@ Livia Xhindoli @@aut@@ Marco Noventa @@aut@@ Marco Agostini @@aut@@ Roberto Tozzi @@aut@@ Carlo Saccardi @@aut@@
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callnumber-first	R - Medicine
author	Giulia Spagnol
spellingShingle	Giulia Spagnol misc RC254-282 misc ovarian cancer misc organoids misc tumor microenvironment misc extracellular matrix misc drug screening misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine
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topic_title	RC254-282 Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine ovarian cancer organoids tumor microenvironment extracellular matrix drug screening
topic	misc RC254-282 misc ovarian cancer misc organoids misc tumor microenvironment misc extracellular matrix misc drug screening misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc ovarian cancer misc organoids misc tumor microenvironment misc extracellular matrix misc drug screening misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc ovarian cancer misc organoids misc tumor microenvironment misc extracellular matrix misc drug screening misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine
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title_full	Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine
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title_sort	patient derived organoids (pdos), extracellular matrix (ecm), tumor microenvironment (tme) and drug screening: state of the art and clinical implications of ovarian cancer organoids in the era of precision medicine
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title_auth	Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine
abstract	Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the rapid development of resistance to conventional chemotherapy. In recent years, in order to overcome these problems, targeted therapies have been introduced in various types of tumors, including gynecological cancer. However, the lack of predictive biomarkers showing different clinical benefits limits the effectiveness of these therapies. This requires the development of preclinical models that can replicate the histological and molecular characteristics of OC subtypes. In this scenario, organoids become an important preclinical model for personalized medicine. In fact, patient-derived organoids (PDO) recapture tumor heterogeneity with the possibility of performing drug screening. However, to best reproduce the patient’s characteristics, it is necessary to develop a specific extracellular matrix (ECM) and introduce a tumor microenvironment (TME), which both represent an actual object of study to improve drug screening, particularly when used in targeted therapy and immunotherapy to guide therapeutic decisions. In this review, we summarize the current state of the art for the screening of PDOs, ECM, TME, and drugs in the setting of OC, as well as discussing the clinical implications and future perspectives for the research of OC organoids.
abstractGer	Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the rapid development of resistance to conventional chemotherapy. In recent years, in order to overcome these problems, targeted therapies have been introduced in various types of tumors, including gynecological cancer. However, the lack of predictive biomarkers showing different clinical benefits limits the effectiveness of these therapies. This requires the development of preclinical models that can replicate the histological and molecular characteristics of OC subtypes. In this scenario, organoids become an important preclinical model for personalized medicine. In fact, patient-derived organoids (PDO) recapture tumor heterogeneity with the possibility of performing drug screening. However, to best reproduce the patient’s characteristics, it is necessary to develop a specific extracellular matrix (ECM) and introduce a tumor microenvironment (TME), which both represent an actual object of study to improve drug screening, particularly when used in targeted therapy and immunotherapy to guide therapeutic decisions. In this review, we summarize the current state of the art for the screening of PDOs, ECM, TME, and drugs in the setting of OC, as well as discussing the clinical implications and future perspectives for the research of OC organoids.
abstract_unstemmed	Ovarian cancer (OC) has the highest mortality rate of all gynecological malignancies due to the high prevalence of advanced stages of diagnosis and the high rate of recurrence. Furthermore, the heterogeneity of OC tumors contributes to the rapid development of resistance to conventional chemotherapy. In recent years, in order to overcome these problems, targeted therapies have been introduced in various types of tumors, including gynecological cancer. However, the lack of predictive biomarkers showing different clinical benefits limits the effectiveness of these therapies. This requires the development of preclinical models that can replicate the histological and molecular characteristics of OC subtypes. In this scenario, organoids become an important preclinical model for personalized medicine. In fact, patient-derived organoids (PDO) recapture tumor heterogeneity with the possibility of performing drug screening. However, to best reproduce the patient’s characteristics, it is necessary to develop a specific extracellular matrix (ECM) and introduce a tumor microenvironment (TME), which both represent an actual object of study to improve drug screening, particularly when used in targeted therapy and immunotherapy to guide therapeutic decisions. In this review, we summarize the current state of the art for the screening of PDOs, ECM, TME, and drugs in the setting of OC, as well as discussing the clinical implications and future perspectives for the research of OC organoids.
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title_short	Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine
url	https://doi.org/10.3390/cancers15072059 https://doaj.org/article/ef4f20d7064b4f1a87c771a8c46bd6ac https://www.mdpi.com/2072-6694/15/7/2059 https://doaj.org/toc/2072-6694
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author2	Francesca Sensi Orazio De Tommasi Matteo Marchetti Giulio Bonaldo Livia Xhindoli Marco Noventa Marco Agostini Roberto Tozzi Carlo Saccardi
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up_date	2024-07-03T22:51:44.410Z
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Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine

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