Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain

Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultan...
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Autor*in:	Ricardo L. Azevedo-Pereira [verfasserIn] Nathan C. Manley [verfasserIn] Chen Dong [verfasserIn] Yue Zhang [verfasserIn] Alex G. Lee [verfasserIn] Yulia Zatulovskaia [verfasserIn] Varun Gupta [verfasserIn] Jennifer Vu [verfasserIn] Summer Han [verfasserIn] Jack E. Berry [verfasserIn] Tonya M. Bliss [verfasserIn] Gary K. Steinberg [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	CP: Neuroscience CP: Stem cell research

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 42(2023), 4, Seite 112353-
Übergeordnetes Werk:	volume:42 ; year:2023 ; number:4 ; pages:112353-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2023.112353

Katalog-ID:	DOAJ089413741

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allfields	10.1016/j.celrep.2023.112353 doi (DE-627)DOAJ089413741 (DE-599)DOAJ60fffa56c0664d14a22e17445291e752 DE-627 ger DE-627 rakwb eng QH301-705.5 Ricardo L. Azevedo-Pereira verfasserin aut Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action. CP: Neuroscience CP: Stem cell research Biology (General) Nathan C. Manley verfasserin aut Chen Dong verfasserin aut Yue Zhang verfasserin aut Alex G. Lee verfasserin aut Yulia Zatulovskaia verfasserin aut Varun Gupta verfasserin aut Jennifer Vu verfasserin aut Summer Han verfasserin aut Jack E. Berry verfasserin aut Tonya M. Bliss verfasserin aut Gary K. Steinberg verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 4, Seite 112353- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:4 pages:112353- https://doi.org/10.1016/j.celrep.2023.112353 kostenfrei https://doaj.org/article/60fffa56c0664d14a22e17445291e752 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723003649 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 4 112353-
spelling	10.1016/j.celrep.2023.112353 doi (DE-627)DOAJ089413741 (DE-599)DOAJ60fffa56c0664d14a22e17445291e752 DE-627 ger DE-627 rakwb eng QH301-705.5 Ricardo L. Azevedo-Pereira verfasserin aut Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action. CP: Neuroscience CP: Stem cell research Biology (General) Nathan C. Manley verfasserin aut Chen Dong verfasserin aut Yue Zhang verfasserin aut Alex G. Lee verfasserin aut Yulia Zatulovskaia verfasserin aut Varun Gupta verfasserin aut Jennifer Vu verfasserin aut Summer Han verfasserin aut Jack E. Berry verfasserin aut Tonya M. Bliss verfasserin aut Gary K. Steinberg verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 4, Seite 112353- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:4 pages:112353- https://doi.org/10.1016/j.celrep.2023.112353 kostenfrei https://doaj.org/article/60fffa56c0664d14a22e17445291e752 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723003649 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 4 112353-
allfields_unstemmed	10.1016/j.celrep.2023.112353 doi (DE-627)DOAJ089413741 (DE-599)DOAJ60fffa56c0664d14a22e17445291e752 DE-627 ger DE-627 rakwb eng QH301-705.5 Ricardo L. Azevedo-Pereira verfasserin aut Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action. CP: Neuroscience CP: Stem cell research Biology (General) Nathan C. Manley verfasserin aut Chen Dong verfasserin aut Yue Zhang verfasserin aut Alex G. Lee verfasserin aut Yulia Zatulovskaia verfasserin aut Varun Gupta verfasserin aut Jennifer Vu verfasserin aut Summer Han verfasserin aut Jack E. Berry verfasserin aut Tonya M. Bliss verfasserin aut Gary K. Steinberg verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 4, Seite 112353- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:4 pages:112353- https://doi.org/10.1016/j.celrep.2023.112353 kostenfrei https://doaj.org/article/60fffa56c0664d14a22e17445291e752 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723003649 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 4 112353-
allfieldsGer	10.1016/j.celrep.2023.112353 doi (DE-627)DOAJ089413741 (DE-599)DOAJ60fffa56c0664d14a22e17445291e752 DE-627 ger DE-627 rakwb eng QH301-705.5 Ricardo L. Azevedo-Pereira verfasserin aut Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action. CP: Neuroscience CP: Stem cell research Biology (General) Nathan C. Manley verfasserin aut Chen Dong verfasserin aut Yue Zhang verfasserin aut Alex G. Lee verfasserin aut Yulia Zatulovskaia verfasserin aut Varun Gupta verfasserin aut Jennifer Vu verfasserin aut Summer Han verfasserin aut Jack E. Berry verfasserin aut Tonya M. Bliss verfasserin aut Gary K. Steinberg verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 4, Seite 112353- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:4 pages:112353- https://doi.org/10.1016/j.celrep.2023.112353 kostenfrei https://doaj.org/article/60fffa56c0664d14a22e17445291e752 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723003649 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 4 112353-
allfieldsSound	10.1016/j.celrep.2023.112353 doi (DE-627)DOAJ089413741 (DE-599)DOAJ60fffa56c0664d14a22e17445291e752 DE-627 ger DE-627 rakwb eng QH301-705.5 Ricardo L. Azevedo-Pereira verfasserin aut Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action. CP: Neuroscience CP: Stem cell research Biology (General) Nathan C. Manley verfasserin aut Chen Dong verfasserin aut Yue Zhang verfasserin aut Alex G. Lee verfasserin aut Yulia Zatulovskaia verfasserin aut Varun Gupta verfasserin aut Jennifer Vu verfasserin aut Summer Han verfasserin aut Jack E. Berry verfasserin aut Tonya M. Bliss verfasserin aut Gary K. Steinberg verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 4, Seite 112353- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:4 pages:112353- https://doi.org/10.1016/j.celrep.2023.112353 kostenfrei https://doaj.org/article/60fffa56c0664d14a22e17445291e752 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723003649 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 4 112353-
language	English
source	In Cell Reports 42(2023), 4, Seite 112353- volume:42 year:2023 number:4 pages:112353-
sourceStr	In Cell Reports 42(2023), 4, Seite 112353- volume:42 year:2023 number:4 pages:112353-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CP: Neuroscience CP: Stem cell research Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Ricardo L. Azevedo-Pereira @@aut@@ Nathan C. Manley @@aut@@ Chen Dong @@aut@@ Yue Zhang @@aut@@ Alex G. Lee @@aut@@ Yulia Zatulovskaia @@aut@@ Varun Gupta @@aut@@ Jennifer Vu @@aut@@ Summer Han @@aut@@ Jack E. Berry @@aut@@ Tonya M. Bliss @@aut@@ Gary K. Steinberg @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ089413741
language_de	englisch
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callnumber-first	Q - Science
author	Ricardo L. Azevedo-Pereira
spellingShingle	Ricardo L. Azevedo-Pereira misc QH301-705.5 misc CP: Neuroscience misc CP: Stem cell research misc Biology (General) Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
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topic_title	QH301-705.5 Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain CP: Neuroscience CP: Stem cell research
topic	misc QH301-705.5 misc CP: Neuroscience misc CP: Stem cell research misc Biology (General)
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title	Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
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title_full	Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
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author_browse	Ricardo L. Azevedo-Pereira Nathan C. Manley Chen Dong Yue Zhang Alex G. Lee Yulia Zatulovskaia Varun Gupta Jennifer Vu Summer Han Jack E. Berry Tonya M. Bliss Gary K. Steinberg
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title_sort	decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
callnumber	QH301-705.5
title_auth	Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
abstract	Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action.
abstractGer	Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action.
abstract_unstemmed	Summary: Stem cell therapy shows promise for multiple disorders; however, the molecular crosstalk between grafted cells and host tissue is largely unknown. Here, we take a step toward addressing this question. Using translating ribosome affinity purification (TRAP) with sequencing tools, we simultaneously decode the transcriptomes of graft and host for human neural stem cells (hNSCs) transplanted into the stroke-injured rat brain. Employing pathway analysis tools, we investigate the interactions between the two transcriptomes to predict molecular pathways linking host and graft genes; as proof of concept, we predict host-secreted factors that signal to the graft and the downstream molecular cascades they trigger in the graft. We identify a potential host-graft crosstalk pathway where BMP6 from the stroke-injured brain induces graft secretion of noggin, a known brain repair factor. Decoding the molecular interplay between graft and host is a critical step toward deciphering the molecular mechanisms of stem cell action.
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title_short	Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
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Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain

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