Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study

Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Met...
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Autor*in:	Shutaro Sumiyoshi [verfasserIn] Jun Kiuchi [verfasserIn] Yoshiaki Kuriu [verfasserIn] Tomohiro Arita [verfasserIn] Hiroki Shimizu [verfasserIn] Wataru Takaki [verfasserIn] Takuma Ohashi [verfasserIn] Yusuke Yamamoto [verfasserIn] Hirotaka Konishi [verfasserIn] Ryo Morimura [verfasserIn] Atsushi Shiozaki [verfasserIn] Hisashi Ikoma [verfasserIn] Takeshi Kubota [verfasserIn] Hitoshi Fujiwara [verfasserIn] Kazuma Okamoto [verfasserIn] Eigo Otsuji [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver

Übergeordnetes Werk:	In: BMC Gastroenterology - BMC, 2003, 23(2023), 1, Seite 8
Übergeordnetes Werk:	volume:23 ; year:2023 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12876-023-02762-y

Katalog-ID:	DOAJ08949802X

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245	1	0	\|a Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study
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520			\|a Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction.
650		4	\|a Colorectal cancer
650		4	\|a Postoperative complication
650		4	\|a Liver dysfunction
650		4	\|a Prognosis
650		4	\|a Risk factor
650		4	\|a Fatty liver
653		0	\|a Diseases of the digestive system. Gastroenterology
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700	0		\|a Hiroki Shimizu \|e verfasserin \|4 aut
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700	0		\|a Ryo Morimura \|e verfasserin \|4 aut
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700	0		\|a Kazuma Okamoto \|e verfasserin \|4 aut
700	0		\|a Eigo Otsuji \|e verfasserin \|4 aut
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allfields	10.1186/s12876-023-02762-y doi (DE-627)DOAJ08949802X (DE-599)DOAJa1ee438ecb9b4d97afdc4bc672851652 DE-627 ger DE-627 rakwb eng RC799-869 Shutaro Sumiyoshi verfasserin aut Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction. Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver Diseases of the digestive system. Gastroenterology Jun Kiuchi verfasserin aut Yoshiaki Kuriu verfasserin aut Tomohiro Arita verfasserin aut Hiroki Shimizu verfasserin aut Wataru Takaki verfasserin aut Takuma Ohashi verfasserin aut Yusuke Yamamoto verfasserin aut Hirotaka Konishi verfasserin aut Ryo Morimura verfasserin aut Atsushi Shiozaki verfasserin aut Hisashi Ikoma verfasserin aut Takeshi Kubota verfasserin aut Hitoshi Fujiwara verfasserin aut Kazuma Okamoto verfasserin aut Eigo Otsuji verfasserin aut In BMC Gastroenterology BMC, 2003 23(2023), 1, Seite 8 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:23 year:2023 number:1 pages:8 https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/article/a1ee438ecb9b4d97afdc4bc672851652 kostenfrei https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 8
spelling	10.1186/s12876-023-02762-y doi (DE-627)DOAJ08949802X (DE-599)DOAJa1ee438ecb9b4d97afdc4bc672851652 DE-627 ger DE-627 rakwb eng RC799-869 Shutaro Sumiyoshi verfasserin aut Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction. Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver Diseases of the digestive system. Gastroenterology Jun Kiuchi verfasserin aut Yoshiaki Kuriu verfasserin aut Tomohiro Arita verfasserin aut Hiroki Shimizu verfasserin aut Wataru Takaki verfasserin aut Takuma Ohashi verfasserin aut Yusuke Yamamoto verfasserin aut Hirotaka Konishi verfasserin aut Ryo Morimura verfasserin aut Atsushi Shiozaki verfasserin aut Hisashi Ikoma verfasserin aut Takeshi Kubota verfasserin aut Hitoshi Fujiwara verfasserin aut Kazuma Okamoto verfasserin aut Eigo Otsuji verfasserin aut In BMC Gastroenterology BMC, 2003 23(2023), 1, Seite 8 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:23 year:2023 number:1 pages:8 https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/article/a1ee438ecb9b4d97afdc4bc672851652 kostenfrei https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 8
allfields_unstemmed	10.1186/s12876-023-02762-y doi (DE-627)DOAJ08949802X (DE-599)DOAJa1ee438ecb9b4d97afdc4bc672851652 DE-627 ger DE-627 rakwb eng RC799-869 Shutaro Sumiyoshi verfasserin aut Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction. Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver Diseases of the digestive system. Gastroenterology Jun Kiuchi verfasserin aut Yoshiaki Kuriu verfasserin aut Tomohiro Arita verfasserin aut Hiroki Shimizu verfasserin aut Wataru Takaki verfasserin aut Takuma Ohashi verfasserin aut Yusuke Yamamoto verfasserin aut Hirotaka Konishi verfasserin aut Ryo Morimura verfasserin aut Atsushi Shiozaki verfasserin aut Hisashi Ikoma verfasserin aut Takeshi Kubota verfasserin aut Hitoshi Fujiwara verfasserin aut Kazuma Okamoto verfasserin aut Eigo Otsuji verfasserin aut In BMC Gastroenterology BMC, 2003 23(2023), 1, Seite 8 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:23 year:2023 number:1 pages:8 https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/article/a1ee438ecb9b4d97afdc4bc672851652 kostenfrei https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 8
allfieldsGer	10.1186/s12876-023-02762-y doi (DE-627)DOAJ08949802X (DE-599)DOAJa1ee438ecb9b4d97afdc4bc672851652 DE-627 ger DE-627 rakwb eng RC799-869 Shutaro Sumiyoshi verfasserin aut Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction. Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver Diseases of the digestive system. Gastroenterology Jun Kiuchi verfasserin aut Yoshiaki Kuriu verfasserin aut Tomohiro Arita verfasserin aut Hiroki Shimizu verfasserin aut Wataru Takaki verfasserin aut Takuma Ohashi verfasserin aut Yusuke Yamamoto verfasserin aut Hirotaka Konishi verfasserin aut Ryo Morimura verfasserin aut Atsushi Shiozaki verfasserin aut Hisashi Ikoma verfasserin aut Takeshi Kubota verfasserin aut Hitoshi Fujiwara verfasserin aut Kazuma Okamoto verfasserin aut Eigo Otsuji verfasserin aut In BMC Gastroenterology BMC, 2003 23(2023), 1, Seite 8 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:23 year:2023 number:1 pages:8 https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/article/a1ee438ecb9b4d97afdc4bc672851652 kostenfrei https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 8
allfieldsSound	10.1186/s12876-023-02762-y doi (DE-627)DOAJ08949802X (DE-599)DOAJa1ee438ecb9b4d97afdc4bc672851652 DE-627 ger DE-627 rakwb eng RC799-869 Shutaro Sumiyoshi verfasserin aut Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction. Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver Diseases of the digestive system. Gastroenterology Jun Kiuchi verfasserin aut Yoshiaki Kuriu verfasserin aut Tomohiro Arita verfasserin aut Hiroki Shimizu verfasserin aut Wataru Takaki verfasserin aut Takuma Ohashi verfasserin aut Yusuke Yamamoto verfasserin aut Hirotaka Konishi verfasserin aut Ryo Morimura verfasserin aut Atsushi Shiozaki verfasserin aut Hisashi Ikoma verfasserin aut Takeshi Kubota verfasserin aut Hitoshi Fujiwara verfasserin aut Kazuma Okamoto verfasserin aut Eigo Otsuji verfasserin aut In BMC Gastroenterology BMC, 2003 23(2023), 1, Seite 8 (DE-627)326643702 (DE-600)2041351-8 1471230X nnns volume:23 year:2023 number:1 pages:8 https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/article/a1ee438ecb9b4d97afdc4bc672851652 kostenfrei https://doi.org/10.1186/s12876-023-02762-y kostenfrei https://doaj.org/toc/1471-230X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2023 1 8
language	English
source	In BMC Gastroenterology 23(2023), 1, Seite 8 volume:23 year:2023 number:1 pages:8
sourceStr	In BMC Gastroenterology 23(2023), 1, Seite 8 volume:23 year:2023 number:1 pages:8
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver Diseases of the digestive system. Gastroenterology
isfreeaccess_bool	true
container_title	BMC Gastroenterology
authorswithroles_txt_mv	Shutaro Sumiyoshi @@aut@@ Jun Kiuchi @@aut@@ Yoshiaki Kuriu @@aut@@ Tomohiro Arita @@aut@@ Hiroki Shimizu @@aut@@ Wataru Takaki @@aut@@ Takuma Ohashi @@aut@@ Yusuke Yamamoto @@aut@@ Hirotaka Konishi @@aut@@ Ryo Morimura @@aut@@ Atsushi Shiozaki @@aut@@ Hisashi Ikoma @@aut@@ Takeshi Kubota @@aut@@ Hitoshi Fujiwara @@aut@@ Kazuma Okamoto @@aut@@ Eigo Otsuji @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	326643702
id	DOAJ08949802X
language_de	englisch
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callnumber-first	R - Medicine
author	Shutaro Sumiyoshi
spellingShingle	Shutaro Sumiyoshi misc RC799-869 misc Colorectal cancer misc Postoperative complication misc Liver dysfunction misc Prognosis misc Risk factor misc Fatty liver misc Diseases of the digestive system. Gastroenterology Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study
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topic_title	RC799-869 Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study Colorectal cancer Postoperative complication Liver dysfunction Prognosis Risk factor Fatty liver
topic	misc RC799-869 misc Colorectal cancer misc Postoperative complication misc Liver dysfunction misc Prognosis misc Risk factor misc Fatty liver misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc Colorectal cancer misc Postoperative complication misc Liver dysfunction misc Prognosis misc Risk factor misc Fatty liver misc Diseases of the digestive system. Gastroenterology
topic_browse	misc RC799-869 misc Colorectal cancer misc Postoperative complication misc Liver dysfunction misc Prognosis misc Risk factor misc Fatty liver misc Diseases of the digestive system. Gastroenterology
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title	Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study
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title_full	Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study
author_sort	Shutaro Sumiyoshi
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author_browse	Shutaro Sumiyoshi Jun Kiuchi Yoshiaki Kuriu Tomohiro Arita Hiroki Shimizu Wataru Takaki Takuma Ohashi Yusuke Yamamoto Hirotaka Konishi Ryo Morimura Atsushi Shiozaki Hisashi Ikoma Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Eigo Otsuji
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title_sort	postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study
callnumber	RC799-869
title_auth	Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study
abstract	Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction.
abstractGer	Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction.
abstract_unstemmed	Abstract Background Postoperative hepatobiliary enzyme abnormalities often present as postoperative liver dysfunction in patients with colorectal cancer. This study aimed to clarify the risk factors of postoperative liver dysfunction and its prognostic impact following colorectal cancer surgery. Methods We retrospectively analyzed data from 360 consecutive patients who underwent radical resection for Stage I–IV colorectal cancer between 2015 and 2019. A subset of 249 patients with Stage III colorectal cancer were examined to assess the prognostic impact of liver dysfunction. Results Forty-eight (13.3%) colorectal cancer patients (Stages I–IV) developed postoperative liver dysfunction (Common Terminology Criteria for Adverse Events version 5.0 CTCAE v5.0 ≥ Grade 2). Univariate and multivariate analyses identified the liver-to-spleen ratio on preoperative plain computed tomography (L/S ratio; P = 0.002, Odds ratio 2.66) as an independent risk factor for liver dysfunction. Patients with postoperative liver dysfunction showed significantly poorer disease-free survival than patients without liver dysfunction (P < 0.001). Univariate and multivariate analyses using Cox’s proportional hazards model revealed that postoperative liver dysfunction independently was a poor prognostic factor (P = 0.001, Hazard ratio 2.75, 95% CI: 1.54–4.73). Conclusions Postoperative liver dysfunction was associated with poor long-term outcomes in patients with Stage III colorectal cancer. A low liver-to-spleen ratio on preoperative plain computed tomography images was an independent risk factor of postoperative liver dysfunction.
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title_short	Postoperative liver dysfunction is associated with poor long-term outcomes in patients with colorectal cancer: a retrospective cohort study
url	https://doi.org/10.1186/s12876-023-02762-y https://doaj.org/article/a1ee438ecb9b4d97afdc4bc672851652 https://doaj.org/toc/1471-230X
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