ZFP36-mediated mRNA decay regulates metabolism

Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional m...
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Autor*in:	Andrew C. Cicchetto [verfasserIn] Elsie C. Jacobson [verfasserIn] Hannah Sunshine [verfasserIn] Blake R. Wilde [verfasserIn] Abigail S. Krall [verfasserIn] Kelsey E. Jarrett [verfasserIn] Leslie Sedgeman [verfasserIn] Martin Turner [verfasserIn] Kathrin Plath [verfasserIn] M. Luisa Iruela-Arispe [verfasserIn] Thomas Q. de Aguiar Vallim [verfasserIn] Heather R. Christofk [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	CP: Metabolism CP: Molecular biology

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 42(2023), 5, Seite 112411-
Übergeordnetes Werk:	volume:42 ; year:2023 ; number:5 ; pages:112411-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2023.112411

Katalog-ID:	DOAJ089511522

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publishDate	2023
allfields	10.1016/j.celrep.2023.112411 doi (DE-627)DOAJ089511522 (DE-599)DOAJ73e0963b38cb4fecacd111d48dec773f DE-627 ger DE-627 rakwb eng QH301-705.5 Andrew C. Cicchetto verfasserin aut ZFP36-mediated mRNA decay regulates metabolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states. CP: Metabolism CP: Molecular biology Biology (General) Elsie C. Jacobson verfasserin aut Hannah Sunshine verfasserin aut Blake R. Wilde verfasserin aut Abigail S. Krall verfasserin aut Kelsey E. Jarrett verfasserin aut Leslie Sedgeman verfasserin aut Martin Turner verfasserin aut Kathrin Plath verfasserin aut M. Luisa Iruela-Arispe verfasserin aut Thomas Q. de Aguiar Vallim verfasserin aut Heather R. Christofk verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 5, Seite 112411- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:5 pages:112411- https://doi.org/10.1016/j.celrep.2023.112411 kostenfrei https://doaj.org/article/73e0963b38cb4fecacd111d48dec773f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723004229 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 5 112411-
spelling	10.1016/j.celrep.2023.112411 doi (DE-627)DOAJ089511522 (DE-599)DOAJ73e0963b38cb4fecacd111d48dec773f DE-627 ger DE-627 rakwb eng QH301-705.5 Andrew C. Cicchetto verfasserin aut ZFP36-mediated mRNA decay regulates metabolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states. CP: Metabolism CP: Molecular biology Biology (General) Elsie C. Jacobson verfasserin aut Hannah Sunshine verfasserin aut Blake R. Wilde verfasserin aut Abigail S. Krall verfasserin aut Kelsey E. Jarrett verfasserin aut Leslie Sedgeman verfasserin aut Martin Turner verfasserin aut Kathrin Plath verfasserin aut M. Luisa Iruela-Arispe verfasserin aut Thomas Q. de Aguiar Vallim verfasserin aut Heather R. Christofk verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 5, Seite 112411- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:5 pages:112411- https://doi.org/10.1016/j.celrep.2023.112411 kostenfrei https://doaj.org/article/73e0963b38cb4fecacd111d48dec773f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723004229 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 5 112411-
allfields_unstemmed	10.1016/j.celrep.2023.112411 doi (DE-627)DOAJ089511522 (DE-599)DOAJ73e0963b38cb4fecacd111d48dec773f DE-627 ger DE-627 rakwb eng QH301-705.5 Andrew C. Cicchetto verfasserin aut ZFP36-mediated mRNA decay regulates metabolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states. CP: Metabolism CP: Molecular biology Biology (General) Elsie C. Jacobson verfasserin aut Hannah Sunshine verfasserin aut Blake R. Wilde verfasserin aut Abigail S. Krall verfasserin aut Kelsey E. Jarrett verfasserin aut Leslie Sedgeman verfasserin aut Martin Turner verfasserin aut Kathrin Plath verfasserin aut M. Luisa Iruela-Arispe verfasserin aut Thomas Q. de Aguiar Vallim verfasserin aut Heather R. Christofk verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 5, Seite 112411- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:5 pages:112411- https://doi.org/10.1016/j.celrep.2023.112411 kostenfrei https://doaj.org/article/73e0963b38cb4fecacd111d48dec773f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723004229 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 5 112411-
allfieldsGer	10.1016/j.celrep.2023.112411 doi (DE-627)DOAJ089511522 (DE-599)DOAJ73e0963b38cb4fecacd111d48dec773f DE-627 ger DE-627 rakwb eng QH301-705.5 Andrew C. Cicchetto verfasserin aut ZFP36-mediated mRNA decay regulates metabolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states. CP: Metabolism CP: Molecular biology Biology (General) Elsie C. Jacobson verfasserin aut Hannah Sunshine verfasserin aut Blake R. Wilde verfasserin aut Abigail S. Krall verfasserin aut Kelsey E. Jarrett verfasserin aut Leslie Sedgeman verfasserin aut Martin Turner verfasserin aut Kathrin Plath verfasserin aut M. Luisa Iruela-Arispe verfasserin aut Thomas Q. de Aguiar Vallim verfasserin aut Heather R. Christofk verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 5, Seite 112411- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:5 pages:112411- https://doi.org/10.1016/j.celrep.2023.112411 kostenfrei https://doaj.org/article/73e0963b38cb4fecacd111d48dec773f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723004229 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 5 112411-
allfieldsSound	10.1016/j.celrep.2023.112411 doi (DE-627)DOAJ089511522 (DE-599)DOAJ73e0963b38cb4fecacd111d48dec773f DE-627 ger DE-627 rakwb eng QH301-705.5 Andrew C. Cicchetto verfasserin aut ZFP36-mediated mRNA decay regulates metabolism 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states. CP: Metabolism CP: Molecular biology Biology (General) Elsie C. Jacobson verfasserin aut Hannah Sunshine verfasserin aut Blake R. Wilde verfasserin aut Abigail S. Krall verfasserin aut Kelsey E. Jarrett verfasserin aut Leslie Sedgeman verfasserin aut Martin Turner verfasserin aut Kathrin Plath verfasserin aut M. Luisa Iruela-Arispe verfasserin aut Thomas Q. de Aguiar Vallim verfasserin aut Heather R. Christofk verfasserin aut In Cell Reports Elsevier, 2015 42(2023), 5, Seite 112411- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:42 year:2023 number:5 pages:112411- https://doi.org/10.1016/j.celrep.2023.112411 kostenfrei https://doaj.org/article/73e0963b38cb4fecacd111d48dec773f kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124723004229 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 42 2023 5 112411-
language	English
source	In Cell Reports 42(2023), 5, Seite 112411- volume:42 year:2023 number:5 pages:112411-
sourceStr	In Cell Reports 42(2023), 5, Seite 112411- volume:42 year:2023 number:5 pages:112411-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CP: Metabolism CP: Molecular biology Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Andrew C. Cicchetto @@aut@@ Elsie C. Jacobson @@aut@@ Hannah Sunshine @@aut@@ Blake R. Wilde @@aut@@ Abigail S. Krall @@aut@@ Kelsey E. Jarrett @@aut@@ Leslie Sedgeman @@aut@@ Martin Turner @@aut@@ Kathrin Plath @@aut@@ M. Luisa Iruela-Arispe @@aut@@ Thomas Q. de Aguiar Vallim @@aut@@ Heather R. Christofk @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ089511522
language_de	englisch
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callnumber-first	Q - Science
author	Andrew C. Cicchetto
spellingShingle	Andrew C. Cicchetto misc QH301-705.5 misc CP: Metabolism misc CP: Molecular biology misc Biology (General) ZFP36-mediated mRNA decay regulates metabolism
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topic_title	QH301-705.5 ZFP36-mediated mRNA decay regulates metabolism CP: Metabolism CP: Molecular biology
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title	ZFP36-mediated mRNA decay regulates metabolism
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title_full	ZFP36-mediated mRNA decay regulates metabolism
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author_browse	Andrew C. Cicchetto Elsie C. Jacobson Hannah Sunshine Blake R. Wilde Abigail S. Krall Kelsey E. Jarrett Leslie Sedgeman Martin Turner Kathrin Plath M. Luisa Iruela-Arispe Thomas Q. de Aguiar Vallim Heather R. Christofk
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author-letter	Andrew C. Cicchetto
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title_sort	zfp36-mediated mrna decay regulates metabolism
callnumber	QH301-705.5
title_auth	ZFP36-mediated mRNA decay regulates metabolism
abstract	Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states.
abstractGer	Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states.
abstract_unstemmed	Summary: Cellular metabolism is tightly regulated by growth factor signaling, which promotes metabolic rewiring to support growth and proliferation. While growth factor-induced transcriptional and post-translational modes of metabolic regulation have been well defined, whether post-transcriptional mechanisms impacting mRNA stability regulate this process is less clear. Here, we present the ZFP36/L1/L2 family of RNA-binding proteins and mRNA decay factors as key drivers of metabolic regulation downstream of acute growth factor signaling. We quantitatively catalog metabolic enzyme and nutrient transporter mRNAs directly bound by ZFP36 following growth factor stimulation—many of which encode rate-limiting steps in metabolic pathways. Further, we show that ZFP36 directly promotes the mRNA decay of Enolase 2 (Eno2), altering Eno2 protein expression and enzymatic activity, and provide evidence of a ZFP36/Eno2 axis during VEGF-stimulated developmental retinal angiogenesis. Thus, ZFP36-mediated mRNA decay serves as an important mode of metabolic regulation downstream of growth factor signaling within dynamic cell and tissue states.
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title_short	ZFP36-mediated mRNA decay regulates metabolism
url	https://doi.org/10.1016/j.celrep.2023.112411 https://doaj.org/article/73e0963b38cb4fecacd111d48dec773f http://www.sciencedirect.com/science/article/pii/S2211124723004229 https://doaj.org/toc/2211-1247
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