Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications

Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the c...
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Autor*in:	Changhuo Xu [verfasserIn] Hanchen Shen [verfasserIn] Tzu-Ming Liu [verfasserIn] Ryan T.K. Kwok [verfasserIn] Jacky W.Y. Lam [verfasserIn] Ben Zhong Tang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Materials science Materials chemistry Biomedical materials

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 26(2023), 5, Seite 106568-
Übergeordnetes Werk:	volume:26 ; year:2023 ; number:5 ; pages:106568-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2023.106568

Katalog-ID:	DOAJ089539966

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allfields	10.1016/j.isci.2023.106568 doi (DE-627)DOAJ089539966 (DE-599)DOAJ53e1cc6a02e74041a78ca165a90c4f8e DE-627 ger DE-627 rakwb eng Changhuo Xu verfasserin aut Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates. Materials science Materials chemistry Biomedical materials Science Q Hanchen Shen verfasserin aut Tzu-Ming Liu verfasserin aut Ryan T.K. Kwok verfasserin aut Jacky W.Y. Lam verfasserin aut Ben Zhong Tang verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106568- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106568- https://doi.org/10.1016/j.isci.2023.106568 kostenfrei https://doaj.org/article/53e1cc6a02e74041a78ca165a90c4f8e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006454 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106568-
spelling	10.1016/j.isci.2023.106568 doi (DE-627)DOAJ089539966 (DE-599)DOAJ53e1cc6a02e74041a78ca165a90c4f8e DE-627 ger DE-627 rakwb eng Changhuo Xu verfasserin aut Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates. Materials science Materials chemistry Biomedical materials Science Q Hanchen Shen verfasserin aut Tzu-Ming Liu verfasserin aut Ryan T.K. Kwok verfasserin aut Jacky W.Y. Lam verfasserin aut Ben Zhong Tang verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106568- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106568- https://doi.org/10.1016/j.isci.2023.106568 kostenfrei https://doaj.org/article/53e1cc6a02e74041a78ca165a90c4f8e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006454 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106568-
allfields_unstemmed	10.1016/j.isci.2023.106568 doi (DE-627)DOAJ089539966 (DE-599)DOAJ53e1cc6a02e74041a78ca165a90c4f8e DE-627 ger DE-627 rakwb eng Changhuo Xu verfasserin aut Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates. Materials science Materials chemistry Biomedical materials Science Q Hanchen Shen verfasserin aut Tzu-Ming Liu verfasserin aut Ryan T.K. Kwok verfasserin aut Jacky W.Y. Lam verfasserin aut Ben Zhong Tang verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106568- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106568- https://doi.org/10.1016/j.isci.2023.106568 kostenfrei https://doaj.org/article/53e1cc6a02e74041a78ca165a90c4f8e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006454 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106568-
allfieldsGer	10.1016/j.isci.2023.106568 doi (DE-627)DOAJ089539966 (DE-599)DOAJ53e1cc6a02e74041a78ca165a90c4f8e DE-627 ger DE-627 rakwb eng Changhuo Xu verfasserin aut Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates. Materials science Materials chemistry Biomedical materials Science Q Hanchen Shen verfasserin aut Tzu-Ming Liu verfasserin aut Ryan T.K. Kwok verfasserin aut Jacky W.Y. Lam verfasserin aut Ben Zhong Tang verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106568- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106568- https://doi.org/10.1016/j.isci.2023.106568 kostenfrei https://doaj.org/article/53e1cc6a02e74041a78ca165a90c4f8e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006454 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106568-
allfieldsSound	10.1016/j.isci.2023.106568 doi (DE-627)DOAJ089539966 (DE-599)DOAJ53e1cc6a02e74041a78ca165a90c4f8e DE-627 ger DE-627 rakwb eng Changhuo Xu verfasserin aut Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates. Materials science Materials chemistry Biomedical materials Science Q Hanchen Shen verfasserin aut Tzu-Ming Liu verfasserin aut Ryan T.K. Kwok verfasserin aut Jacky W.Y. Lam verfasserin aut Ben Zhong Tang verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106568- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106568- https://doi.org/10.1016/j.isci.2023.106568 kostenfrei https://doaj.org/article/53e1cc6a02e74041a78ca165a90c4f8e kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006454 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106568-
language	English
source	In iScience 26(2023), 5, Seite 106568- volume:26 year:2023 number:5 pages:106568-
sourceStr	In iScience 26(2023), 5, Seite 106568- volume:26 year:2023 number:5 pages:106568-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Materials science Materials chemistry Biomedical materials Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Changhuo Xu @@aut@@ Hanchen Shen @@aut@@ Tzu-Ming Liu @@aut@@ Ryan T.K. Kwok @@aut@@ Jacky W.Y. Lam @@aut@@ Ben Zhong Tang @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ089539966
language_de	englisch
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author	Changhuo Xu
spellingShingle	Changhuo Xu misc Materials science misc Materials chemistry misc Biomedical materials misc Science misc Q Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications
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topic_title	Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications Materials science Materials chemistry Biomedical materials
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title	Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications
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title_full	Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications
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author_browse	Changhuo Xu Hanchen Shen Tzu-Ming Liu Ryan T.K. Kwok Jacky W.Y. Lam Ben Zhong Tang
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title_sort	restriction of molecular motion to a higher level: towards bright aie dots for biomedical applications
title_auth	Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications
abstract	Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates.
abstractGer	Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates.
abstract_unstemmed	Summary: In the late 19th century, scientists began to study the photophysical differences between chromophores in the solution and aggregate states, which breed the recognition of the prototypical processes of aggregation-caused quenching and aggregation-induced emission (AIE). In particular, the conceptual discovery of the AIE phenomenon has spawned the innovation of luminogenic materials with high emission in the aggregate state based on their unique working principle termed the restriction of intramolecular motion. As AIE luminogens have been practically fabricated into AIE dots for bioimaging, further improvement of their brightness is needed although this is technically challenging. In this review, we surveyed the recent advances in strategic molecular engineering of highly emissive AIE dots, including nanoscale crystallization and matrix-assisted rigidification. We hope that this timely summary can deepen the understanding about the root cause of the high emission of AIE dots and provide inspiration to the rational design of functional aggregates.
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title_short	Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications
url	https://doi.org/10.1016/j.isci.2023.106568 https://doaj.org/article/53e1cc6a02e74041a78ca165a90c4f8e http://www.sciencedirect.com/science/article/pii/S2589004223006454 https://doaj.org/toc/2589-0042
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up_date	2024-07-03T23:35:26.490Z
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Restriction of molecular motion to a higher level: Towards bright AIE dots for biomedical applications

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