Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis

Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis. Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular matrix (ECM) proteins such as collagens, glycoproteins, and proteoglycans (PGs) in the hepatic parenchyma. Changes in...
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Autor*in:	Yuan-Quan Zhao [verfasserIn] Xi-Wen Deng [verfasserIn] Guo-Qi Xu [verfasserIn] Jie Lin [verfasserIn] Hua-Ze Lu [verfasserIn] Jie Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	hepatic fibrosis biomechanics extracellular matrix hepatic stellate cells mechanotransduction

Übergeordnetes Werk:	In: Frontiers in Molecular Biosciences - Frontiers Media S.A., 2015, 10(2023)
Übergeordnetes Werk:	volume:10 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fmolb.2023.1183808

Katalog-ID:	DOAJ089575121

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520			\|a Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis. Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular matrix (ECM) proteins such as collagens, glycoproteins, and proteoglycans (PGs) in the hepatic parenchyma. Changes in the composition of the ECM lead to the stiffness of the matrix that destroys its inherent mechanical homeostasis, and a mechanical homeostasis imbalance activates hepatic stellate cells (HSCs) into myofibroblasts, which can overproliferate and secrete large amounts of ECM proteins. Excessive ECM proteins are gradually deposited in the Disse gap, and matrix regeneration fails, which further leads to changes in ECM components and an increase in stiffness, forming a vicious cycle. These processes promote the occurrence and development of hepatic fibrosis. In this review, the dynamic process of ECM remodeling of HF and the activation of HSCs into mechanotransduction signaling pathways for myofibroblasts to participate in HF are discussed. These mechanotransduction signaling pathways may have potential therapeutic targets for repairing or reversing fibrosis.
650		4	\|a hepatic fibrosis
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language	English
source	In Frontiers in Molecular Biosciences 10(2023) volume:10 year:2023
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topic_facet	hepatic fibrosis biomechanics extracellular matrix hepatic stellate cells mechanotransduction Biology (General)
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authorswithroles_txt_mv	Yuan-Quan Zhao @@aut@@ Xi-Wen Deng @@aut@@ Guo-Qi Xu @@aut@@ Jie Lin @@aut@@ Hua-Ze Lu @@aut@@ Jie Chen @@aut@@
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callnumber-first	Q - Science
author	Yuan-Quan Zhao
spellingShingle	Yuan-Quan Zhao misc QH301-705.5 misc hepatic fibrosis misc biomechanics misc extracellular matrix misc hepatic stellate cells misc mechanotransduction misc Biology (General) Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
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topic_title	QH301-705.5 Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis hepatic fibrosis biomechanics extracellular matrix hepatic stellate cells mechanotransduction
topic	misc QH301-705.5 misc hepatic fibrosis misc biomechanics misc extracellular matrix misc hepatic stellate cells misc mechanotransduction misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc hepatic fibrosis misc biomechanics misc extracellular matrix misc hepatic stellate cells misc mechanotransduction misc Biology (General)
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title	Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
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title_full	Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
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title_sort	mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
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title_auth	Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
abstract	Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis. Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular matrix (ECM) proteins such as collagens, glycoproteins, and proteoglycans (PGs) in the hepatic parenchyma. Changes in the composition of the ECM lead to the stiffness of the matrix that destroys its inherent mechanical homeostasis, and a mechanical homeostasis imbalance activates hepatic stellate cells (HSCs) into myofibroblasts, which can overproliferate and secrete large amounts of ECM proteins. Excessive ECM proteins are gradually deposited in the Disse gap, and matrix regeneration fails, which further leads to changes in ECM components and an increase in stiffness, forming a vicious cycle. These processes promote the occurrence and development of hepatic fibrosis. In this review, the dynamic process of ECM remodeling of HF and the activation of HSCs into mechanotransduction signaling pathways for myofibroblasts to participate in HF are discussed. These mechanotransduction signaling pathways may have potential therapeutic targets for repairing or reversing fibrosis.
abstractGer	Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis. Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular matrix (ECM) proteins such as collagens, glycoproteins, and proteoglycans (PGs) in the hepatic parenchyma. Changes in the composition of the ECM lead to the stiffness of the matrix that destroys its inherent mechanical homeostasis, and a mechanical homeostasis imbalance activates hepatic stellate cells (HSCs) into myofibroblasts, which can overproliferate and secrete large amounts of ECM proteins. Excessive ECM proteins are gradually deposited in the Disse gap, and matrix regeneration fails, which further leads to changes in ECM components and an increase in stiffness, forming a vicious cycle. These processes promote the occurrence and development of hepatic fibrosis. In this review, the dynamic process of ECM remodeling of HF and the activation of HSCs into mechanotransduction signaling pathways for myofibroblasts to participate in HF are discussed. These mechanotransduction signaling pathways may have potential therapeutic targets for repairing or reversing fibrosis.
abstract_unstemmed	Chronic liver disease or repeated damage to hepatocytes can give rise to hepatic fibrosis. Hepatic fibrosis (HF) is a pathological process of excessive sedimentation of extracellular matrix (ECM) proteins such as collagens, glycoproteins, and proteoglycans (PGs) in the hepatic parenchyma. Changes in the composition of the ECM lead to the stiffness of the matrix that destroys its inherent mechanical homeostasis, and a mechanical homeostasis imbalance activates hepatic stellate cells (HSCs) into myofibroblasts, which can overproliferate and secrete large amounts of ECM proteins. Excessive ECM proteins are gradually deposited in the Disse gap, and matrix regeneration fails, which further leads to changes in ECM components and an increase in stiffness, forming a vicious cycle. These processes promote the occurrence and development of hepatic fibrosis. In this review, the dynamic process of ECM remodeling of HF and the activation of HSCs into mechanotransduction signaling pathways for myofibroblasts to participate in HF are discussed. These mechanotransduction signaling pathways may have potential therapeutic targets for repairing or reversing fibrosis.
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title_short	Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
url	https://doi.org/10.3389/fmolb.2023.1183808 https://doaj.org/article/b641b623d10a4ed6bcc043a058020b37 https://www.frontiersin.org/articles/10.3389/fmolb.2023.1183808/full https://doaj.org/toc/2296-889X
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