Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota

Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbi...
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Autor*in:	Yixuan Li [verfasserIn] Zizhong Liu [verfasserIn] Gui Luo [verfasserIn] Haiyun Lan [verfasserIn] Pu Chen [verfasserIn] Ruikai Du [verfasserIn] Gongchao Jing [verfasserIn] Lu Liu [verfasserIn] Xiaohan Cui [verfasserIn] Yongzhi Li [verfasserIn] Yanping Han [verfasserIn] Jian Xu [verfasserIn] Hongwei Zhu [verfasserIn] Shukuan Ling [verfasserIn] Yingxian Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Genomics Genomic analysis Space sciences

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 26(2023), 5, Seite 106615-
Übergeordnetes Werk:	volume:26 ; year:2023 ; number:5 ; pages:106615-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2023.106615

Katalog-ID:	DOAJ089592891

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520			\|a Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota.
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allfields	10.1016/j.isci.2023.106615 doi (DE-627)DOAJ089592891 (DE-599)DOAJ517ac2753661488687d706ae75b38c7a DE-627 ger DE-627 rakwb eng Yixuan Li verfasserin aut Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota. Genomics Genomic analysis Space sciences Science Q Zizhong Liu verfasserin aut Gui Luo verfasserin aut Haiyun Lan verfasserin aut Pu Chen verfasserin aut Ruikai Du verfasserin aut Gongchao Jing verfasserin aut Lu Liu verfasserin aut Xiaohan Cui verfasserin aut Yongzhi Li verfasserin aut Yanping Han verfasserin aut Jian Xu verfasserin aut Hongwei Zhu verfasserin aut Shukuan Ling verfasserin aut Yingxian Li verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106615- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106615- https://doi.org/10.1016/j.isci.2023.106615 kostenfrei https://doaj.org/article/517ac2753661488687d706ae75b38c7a kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006922 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106615-
spelling	10.1016/j.isci.2023.106615 doi (DE-627)DOAJ089592891 (DE-599)DOAJ517ac2753661488687d706ae75b38c7a DE-627 ger DE-627 rakwb eng Yixuan Li verfasserin aut Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota. Genomics Genomic analysis Space sciences Science Q Zizhong Liu verfasserin aut Gui Luo verfasserin aut Haiyun Lan verfasserin aut Pu Chen verfasserin aut Ruikai Du verfasserin aut Gongchao Jing verfasserin aut Lu Liu verfasserin aut Xiaohan Cui verfasserin aut Yongzhi Li verfasserin aut Yanping Han verfasserin aut Jian Xu verfasserin aut Hongwei Zhu verfasserin aut Shukuan Ling verfasserin aut Yingxian Li verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106615- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106615- https://doi.org/10.1016/j.isci.2023.106615 kostenfrei https://doaj.org/article/517ac2753661488687d706ae75b38c7a kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006922 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106615-
allfields_unstemmed	10.1016/j.isci.2023.106615 doi (DE-627)DOAJ089592891 (DE-599)DOAJ517ac2753661488687d706ae75b38c7a DE-627 ger DE-627 rakwb eng Yixuan Li verfasserin aut Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota. Genomics Genomic analysis Space sciences Science Q Zizhong Liu verfasserin aut Gui Luo verfasserin aut Haiyun Lan verfasserin aut Pu Chen verfasserin aut Ruikai Du verfasserin aut Gongchao Jing verfasserin aut Lu Liu verfasserin aut Xiaohan Cui verfasserin aut Yongzhi Li verfasserin aut Yanping Han verfasserin aut Jian Xu verfasserin aut Hongwei Zhu verfasserin aut Shukuan Ling verfasserin aut Yingxian Li verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106615- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106615- https://doi.org/10.1016/j.isci.2023.106615 kostenfrei https://doaj.org/article/517ac2753661488687d706ae75b38c7a kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006922 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106615-
allfieldsGer	10.1016/j.isci.2023.106615 doi (DE-627)DOAJ089592891 (DE-599)DOAJ517ac2753661488687d706ae75b38c7a DE-627 ger DE-627 rakwb eng Yixuan Li verfasserin aut Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota. Genomics Genomic analysis Space sciences Science Q Zizhong Liu verfasserin aut Gui Luo verfasserin aut Haiyun Lan verfasserin aut Pu Chen verfasserin aut Ruikai Du verfasserin aut Gongchao Jing verfasserin aut Lu Liu verfasserin aut Xiaohan Cui verfasserin aut Yongzhi Li verfasserin aut Yanping Han verfasserin aut Jian Xu verfasserin aut Hongwei Zhu verfasserin aut Shukuan Ling verfasserin aut Yingxian Li verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106615- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106615- https://doi.org/10.1016/j.isci.2023.106615 kostenfrei https://doaj.org/article/517ac2753661488687d706ae75b38c7a kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006922 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106615-
allfieldsSound	10.1016/j.isci.2023.106615 doi (DE-627)DOAJ089592891 (DE-599)DOAJ517ac2753661488687d706ae75b38c7a DE-627 ger DE-627 rakwb eng Yixuan Li verfasserin aut Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota. Genomics Genomic analysis Space sciences Science Q Zizhong Liu verfasserin aut Gui Luo verfasserin aut Haiyun Lan verfasserin aut Pu Chen verfasserin aut Ruikai Du verfasserin aut Gongchao Jing verfasserin aut Lu Liu verfasserin aut Xiaohan Cui verfasserin aut Yongzhi Li verfasserin aut Yanping Han verfasserin aut Jian Xu verfasserin aut Hongwei Zhu verfasserin aut Shukuan Ling verfasserin aut Yingxian Li verfasserin aut In iScience Elsevier, 2019 26(2023), 5, Seite 106615- (DE-627)1019532106 25890042 nnns volume:26 year:2023 number:5 pages:106615- https://doi.org/10.1016/j.isci.2023.106615 kostenfrei https://doaj.org/article/517ac2753661488687d706ae75b38c7a kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004223006922 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2023 5 106615-
language	English
source	In iScience 26(2023), 5, Seite 106615- volume:26 year:2023 number:5 pages:106615-
sourceStr	In iScience 26(2023), 5, Seite 106615- volume:26 year:2023 number:5 pages:106615-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genomics Genomic analysis Space sciences Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Yixuan Li @@aut@@ Zizhong Liu @@aut@@ Gui Luo @@aut@@ Haiyun Lan @@aut@@ Pu Chen @@aut@@ Ruikai Du @@aut@@ Gongchao Jing @@aut@@ Lu Liu @@aut@@ Xiaohan Cui @@aut@@ Yongzhi Li @@aut@@ Yanping Han @@aut@@ Jian Xu @@aut@@ Hongwei Zhu @@aut@@ Shukuan Ling @@aut@@ Yingxian Li @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ089592891
language_de	englisch
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author	Yixuan Li
spellingShingle	Yixuan Li misc Genomics misc Genomic analysis misc Space sciences misc Science misc Q Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota
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topic_title	Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota Genomics Genomic analysis Space sciences
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title	Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota
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title_full	Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota
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author_browse	Yixuan Li Zizhong Liu Gui Luo Haiyun Lan Pu Chen Ruikai Du Gongchao Jing Lu Liu Xiaohan Cui Yongzhi Li Yanping Han Jian Xu Hongwei Zhu Shukuan Ling Yingxian Li
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author-letter	Yixuan Li
doi_str_mv	10.1016/j.isci.2023.106615
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title_sort	effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota
title_auth	Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota
abstract	Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota.
abstractGer	Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota.
abstract_unstemmed	Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota under simulated microgravity. The gut microbiota of volunteers was analyzed and characterized by 16S rRNA gene sequencing and metagenomic sequencing. Our results showed that the composition and function of the volunteers’ gut microbiota were markedly was affected by 60 days of 6° HDBR. We further confirmed the species and diversity fluctuations. Resistance and virulence genes in the gut microbiota were also affected by 60 days of 6° HDBR, but the species attributions remained stable. The human gut microbiota affected by 60 days of 6° HDBR which was partially consistent with the effect of spaceflight, this implied that HDBR was a simulation of how spaceflight affects the human gut microbiota.
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title_short	Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota
url	https://doi.org/10.1016/j.isci.2023.106615 https://doaj.org/article/517ac2753661488687d706ae75b38c7a http://www.sciencedirect.com/science/article/pii/S2589004223006922 https://doaj.org/toc/2589-0042
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up_date	2024-07-03T23:49:55.354Z
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Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota

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