In vivo reprogramming: A new approach for tissue repair in chronic diseases

Medical researchers and biologists have long been fascinated by the possibility of changing the identity of cells, a phenomenon known as cellular plasticity. Now, we know that differentiated cells can be experimentally coaxed to become pluripotent (cellular reprogramming). Recent studies have demons...
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Gespeichert in:

Autor*in:	Saman Esmaeilnejad [verfasserIn] Esmaeil Rahimi [verfasserIn] Mohammad Sajad Emami-Aleagha [verfasserIn] Iman Sadeghi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	cellular reprogramming chronic disease guided tissue regeneration cellular reprogramming techniques

Übergeordnetes Werk:	In: Chronic Diseases Journal - Vesnu Publications, 2019, 5(2017), 2, Seite 80-89
Übergeordnetes Werk:	volume:5 ; year:2017 ; number:2 ; pages:80-89

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ089658930

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allfieldsGer	(DE-627)DOAJ089658930 (DE-599)DOAJ0c55a71a9931499da84ccdf0cb3ca835 DE-627 ger DE-627 rakwb eng Saman Esmaeilnejad verfasserin aut In vivo reprogramming: A new approach for tissue repair in chronic diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Medical researchers and biologists have long been fascinated by the possibility of changing the identity of cells, a phenomenon known as cellular plasticity. Now, we know that differentiated cells can be experimentally coaxed to become pluripotent (cellular reprogramming). Recent studies have demonstrated that changes in cell identity are not limited to the laboratory, but also the tissue cells in live organisms are subjected to this process, too (endogenous cellular reprograming). Nowadays “reprogramming technology” has created new opportunities in understanding human chronic diseases, drug discovery, and regenerative medicine. This technology have enabled the generation of various specific cell types including cardiomyocytes, pancreatic beta cell, and neurons, from patient’s cells such as skin fibroblasts. Reprogramming technology provides a novel cell source for autologous cell transplantation. But, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which uses endogenous cells for tissue repair, has emerged as a new approach to circumvent cell transplantation. Up till now, in vivo reprogramming has been practiced in the mouse pancreas, heart, brain, and spinal cord with various degrees of success. In this review, we summarize the progress made, therapeutic potentials, and the challenges ahead in this emerging research area. cellular reprogramming chronic disease guided tissue regeneration cellular reprogramming techniques Medicine R Esmaeil Rahimi verfasserin aut Mohammad Sajad Emami-Aleagha verfasserin aut Iman Sadeghi verfasserin aut In Chronic Diseases Journal Vesnu Publications, 2019 5(2017), 2, Seite 80-89 (DE-627)1683795849 23452226 nnns volume:5 year:2017 number:2 pages:80-89 https://doi.org/10.22122/cdj.v5i2.237 kostenfrei https://doaj.org/article/0c55a71a9931499da84ccdf0cb3ca835 kostenfrei http://cdjournal.muk.ac.ir/index.php/cdj/article/view/237 kostenfrei https://doaj.org/toc/2345-2226 Journal toc kostenfrei https://doaj.org/toc/2588-7297 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2017 2 80-89
allfieldsSound	(DE-627)DOAJ089658930 (DE-599)DOAJ0c55a71a9931499da84ccdf0cb3ca835 DE-627 ger DE-627 rakwb eng Saman Esmaeilnejad verfasserin aut In vivo reprogramming: A new approach for tissue repair in chronic diseases 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Medical researchers and biologists have long been fascinated by the possibility of changing the identity of cells, a phenomenon known as cellular plasticity. Now, we know that differentiated cells can be experimentally coaxed to become pluripotent (cellular reprogramming). Recent studies have demonstrated that changes in cell identity are not limited to the laboratory, but also the tissue cells in live organisms are subjected to this process, too (endogenous cellular reprograming). Nowadays “reprogramming technology” has created new opportunities in understanding human chronic diseases, drug discovery, and regenerative medicine. This technology have enabled the generation of various specific cell types including cardiomyocytes, pancreatic beta cell, and neurons, from patient’s cells such as skin fibroblasts. Reprogramming technology provides a novel cell source for autologous cell transplantation. But, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which uses endogenous cells for tissue repair, has emerged as a new approach to circumvent cell transplantation. Up till now, in vivo reprogramming has been practiced in the mouse pancreas, heart, brain, and spinal cord with various degrees of success. In this review, we summarize the progress made, therapeutic potentials, and the challenges ahead in this emerging research area. cellular reprogramming chronic disease guided tissue regeneration cellular reprogramming techniques Medicine R Esmaeil Rahimi verfasserin aut Mohammad Sajad Emami-Aleagha verfasserin aut Iman Sadeghi verfasserin aut In Chronic Diseases Journal Vesnu Publications, 2019 5(2017), 2, Seite 80-89 (DE-627)1683795849 23452226 nnns volume:5 year:2017 number:2 pages:80-89 https://doi.org/10.22122/cdj.v5i2.237 kostenfrei https://doaj.org/article/0c55a71a9931499da84ccdf0cb3ca835 kostenfrei http://cdjournal.muk.ac.ir/index.php/cdj/article/view/237 kostenfrei https://doaj.org/toc/2345-2226 Journal toc kostenfrei https://doaj.org/toc/2588-7297 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2017 2 80-89
language	English
source	In Chronic Diseases Journal 5(2017), 2, Seite 80-89 volume:5 year:2017 number:2 pages:80-89
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format_phy_str_mv	Article
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topic_facet	cellular reprogramming chronic disease guided tissue regeneration cellular reprogramming techniques Medicine R
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authorswithroles_txt_mv	Saman Esmaeilnejad @@aut@@ Esmaeil Rahimi @@aut@@ Mohammad Sajad Emami-Aleagha @@aut@@ Iman Sadeghi @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
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title	In vivo reprogramming: A new approach for tissue repair in chronic diseases
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title_auth	In vivo reprogramming: A new approach for tissue repair in chronic diseases
abstract	Medical researchers and biologists have long been fascinated by the possibility of changing the identity of cells, a phenomenon known as cellular plasticity. Now, we know that differentiated cells can be experimentally coaxed to become pluripotent (cellular reprogramming). Recent studies have demonstrated that changes in cell identity are not limited to the laboratory, but also the tissue cells in live organisms are subjected to this process, too (endogenous cellular reprograming). Nowadays “reprogramming technology” has created new opportunities in understanding human chronic diseases, drug discovery, and regenerative medicine. This technology have enabled the generation of various specific cell types including cardiomyocytes, pancreatic beta cell, and neurons, from patient’s cells such as skin fibroblasts. Reprogramming technology provides a novel cell source for autologous cell transplantation. But, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which uses endogenous cells for tissue repair, has emerged as a new approach to circumvent cell transplantation. Up till now, in vivo reprogramming has been practiced in the mouse pancreas, heart, brain, and spinal cord with various degrees of success. In this review, we summarize the progress made, therapeutic potentials, and the challenges ahead in this emerging research area.
abstractGer	Medical researchers and biologists have long been fascinated by the possibility of changing the identity of cells, a phenomenon known as cellular plasticity. Now, we know that differentiated cells can be experimentally coaxed to become pluripotent (cellular reprogramming). Recent studies have demonstrated that changes in cell identity are not limited to the laboratory, but also the tissue cells in live organisms are subjected to this process, too (endogenous cellular reprograming). Nowadays “reprogramming technology” has created new opportunities in understanding human chronic diseases, drug discovery, and regenerative medicine. This technology have enabled the generation of various specific cell types including cardiomyocytes, pancreatic beta cell, and neurons, from patient’s cells such as skin fibroblasts. Reprogramming technology provides a novel cell source for autologous cell transplantation. But, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which uses endogenous cells for tissue repair, has emerged as a new approach to circumvent cell transplantation. Up till now, in vivo reprogramming has been practiced in the mouse pancreas, heart, brain, and spinal cord with various degrees of success. In this review, we summarize the progress made, therapeutic potentials, and the challenges ahead in this emerging research area.
abstract_unstemmed	Medical researchers and biologists have long been fascinated by the possibility of changing the identity of cells, a phenomenon known as cellular plasticity. Now, we know that differentiated cells can be experimentally coaxed to become pluripotent (cellular reprogramming). Recent studies have demonstrated that changes in cell identity are not limited to the laboratory, but also the tissue cells in live organisms are subjected to this process, too (endogenous cellular reprograming). Nowadays “reprogramming technology” has created new opportunities in understanding human chronic diseases, drug discovery, and regenerative medicine. This technology have enabled the generation of various specific cell types including cardiomyocytes, pancreatic beta cell, and neurons, from patient’s cells such as skin fibroblasts. Reprogramming technology provides a novel cell source for autologous cell transplantation. But, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which uses endogenous cells for tissue repair, has emerged as a new approach to circumvent cell transplantation. Up till now, in vivo reprogramming has been practiced in the mouse pancreas, heart, brain, and spinal cord with various degrees of success. In this review, we summarize the progress made, therapeutic potentials, and the challenges ahead in this emerging research area.
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title_short	In vivo reprogramming: A new approach for tissue repair in chronic diseases
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