Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace

Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, s...
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Autor*in:	Francesco Errichiello [verfasserIn] Maria D'Amato [verfasserIn] Angelita Gambuti [verfasserIn] Luigi Moio [verfasserIn] Arianna Pastore [verfasserIn] Hekmat AL-Hmadi [verfasserIn] Mariano Stornaiuolo [verfasserIn] Elena Serino [verfasserIn] Orazio Taglialatela-Scafati [verfasserIn] Martino Forino [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 104(2023), Seite 105548-
Übergeordnetes Werk:	volume:104 ; year:2023 ; pages:105548-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2023.105548

Katalog-ID:	DOAJ08970617X

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allfields	10.1016/j.jff.2023.105548 doi (DE-627)DOAJ08970617X (DE-599)DOAJd6c5aa45b381448db307de11a3f84b6f DE-627 ger DE-627 rakwb eng TX341-641 Francesco Errichiello verfasserin aut Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite. Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes Nutrition. Foods and food supply Maria D'Amato verfasserin aut Angelita Gambuti verfasserin aut Luigi Moio verfasserin aut Arianna Pastore verfasserin aut Hekmat AL-Hmadi verfasserin aut Mariano Stornaiuolo verfasserin aut Elena Serino verfasserin aut Orazio Taglialatela-Scafati verfasserin aut Martino Forino verfasserin aut In Journal of Functional Foods Elsevier, 2021 104(2023), Seite 105548- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:104 year:2023 pages:105548- https://doi.org/10.1016/j.jff.2023.105548 kostenfrei https://doaj.org/article/d6c5aa45b381448db307de11a3f84b6f kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464623001482 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 104 2023 105548-
spelling	10.1016/j.jff.2023.105548 doi (DE-627)DOAJ08970617X (DE-599)DOAJd6c5aa45b381448db307de11a3f84b6f DE-627 ger DE-627 rakwb eng TX341-641 Francesco Errichiello verfasserin aut Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite. Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes Nutrition. Foods and food supply Maria D'Amato verfasserin aut Angelita Gambuti verfasserin aut Luigi Moio verfasserin aut Arianna Pastore verfasserin aut Hekmat AL-Hmadi verfasserin aut Mariano Stornaiuolo verfasserin aut Elena Serino verfasserin aut Orazio Taglialatela-Scafati verfasserin aut Martino Forino verfasserin aut In Journal of Functional Foods Elsevier, 2021 104(2023), Seite 105548- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:104 year:2023 pages:105548- https://doi.org/10.1016/j.jff.2023.105548 kostenfrei https://doaj.org/article/d6c5aa45b381448db307de11a3f84b6f kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464623001482 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 104 2023 105548-
allfields_unstemmed	10.1016/j.jff.2023.105548 doi (DE-627)DOAJ08970617X (DE-599)DOAJd6c5aa45b381448db307de11a3f84b6f DE-627 ger DE-627 rakwb eng TX341-641 Francesco Errichiello verfasserin aut Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite. Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes Nutrition. Foods and food supply Maria D'Amato verfasserin aut Angelita Gambuti verfasserin aut Luigi Moio verfasserin aut Arianna Pastore verfasserin aut Hekmat AL-Hmadi verfasserin aut Mariano Stornaiuolo verfasserin aut Elena Serino verfasserin aut Orazio Taglialatela-Scafati verfasserin aut Martino Forino verfasserin aut In Journal of Functional Foods Elsevier, 2021 104(2023), Seite 105548- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:104 year:2023 pages:105548- https://doi.org/10.1016/j.jff.2023.105548 kostenfrei https://doaj.org/article/d6c5aa45b381448db307de11a3f84b6f kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464623001482 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 104 2023 105548-
allfieldsGer	10.1016/j.jff.2023.105548 doi (DE-627)DOAJ08970617X (DE-599)DOAJd6c5aa45b381448db307de11a3f84b6f DE-627 ger DE-627 rakwb eng TX341-641 Francesco Errichiello verfasserin aut Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite. Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes Nutrition. Foods and food supply Maria D'Amato verfasserin aut Angelita Gambuti verfasserin aut Luigi Moio verfasserin aut Arianna Pastore verfasserin aut Hekmat AL-Hmadi verfasserin aut Mariano Stornaiuolo verfasserin aut Elena Serino verfasserin aut Orazio Taglialatela-Scafati verfasserin aut Martino Forino verfasserin aut In Journal of Functional Foods Elsevier, 2021 104(2023), Seite 105548- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:104 year:2023 pages:105548- https://doi.org/10.1016/j.jff.2023.105548 kostenfrei https://doaj.org/article/d6c5aa45b381448db307de11a3f84b6f kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464623001482 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 104 2023 105548-
allfieldsSound	10.1016/j.jff.2023.105548 doi (DE-627)DOAJ08970617X (DE-599)DOAJd6c5aa45b381448db307de11a3f84b6f DE-627 ger DE-627 rakwb eng TX341-641 Francesco Errichiello verfasserin aut Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite. Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes Nutrition. Foods and food supply Maria D'Amato verfasserin aut Angelita Gambuti verfasserin aut Luigi Moio verfasserin aut Arianna Pastore verfasserin aut Hekmat AL-Hmadi verfasserin aut Mariano Stornaiuolo verfasserin aut Elena Serino verfasserin aut Orazio Taglialatela-Scafati verfasserin aut Martino Forino verfasserin aut In Journal of Functional Foods Elsevier, 2021 104(2023), Seite 105548- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:104 year:2023 pages:105548- https://doi.org/10.1016/j.jff.2023.105548 kostenfrei https://doaj.org/article/d6c5aa45b381448db307de11a3f84b6f kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464623001482 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 104 2023 105548-
language	English
source	In Journal of Functional Foods 104(2023), Seite 105548- volume:104 year:2023 pages:105548-
sourceStr	In Journal of Functional Foods 104(2023), Seite 105548- volume:104 year:2023 pages:105548-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Journal of Functional Foods
authorswithroles_txt_mv	Francesco Errichiello @@aut@@ Maria D'Amato @@aut@@ Angelita Gambuti @@aut@@ Luigi Moio @@aut@@ Arianna Pastore @@aut@@ Hekmat AL-Hmadi @@aut@@ Mariano Stornaiuolo @@aut@@ Elena Serino @@aut@@ Orazio Taglialatela-Scafati @@aut@@ Martino Forino @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	587138432
id	DOAJ08970617X
language_de	englisch
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callnumber-first	T - Technology
author	Francesco Errichiello
spellingShingle	Francesco Errichiello misc TX341-641 misc Grape pomace valorization misc Oleanolic acid misc Natural triterpenoid misc Antidiabetic metabolite misc Red grapes misc Nutrition. Foods and food supply Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace
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topic_title	TX341-641 Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace Grape pomace valorization Oleanolic acid Natural triterpenoid Antidiabetic metabolite Red grapes
topic	misc TX341-641 misc Grape pomace valorization misc Oleanolic acid misc Natural triterpenoid misc Antidiabetic metabolite misc Red grapes misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Grape pomace valorization misc Oleanolic acid misc Natural triterpenoid misc Antidiabetic metabolite misc Red grapes misc Nutrition. Foods and food supply
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title	Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace
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title_full	Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace
author_sort	Francesco Errichiello
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author_browse	Francesco Errichiello Maria D'Amato Angelita Gambuti Luigi Moio Arianna Pastore Hekmat AL-Hmadi Mariano Stornaiuolo Elena Serino Orazio Taglialatela-Scafati Martino Forino
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title_sort	oleanolic acid: a promising antidiabetic metabolite detected in aglianico grape pomace
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title_auth	Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace
abstract	Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite.
abstractGer	Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite.
abstract_unstemmed	Grape pomace, a bulky component of winery waste, is a source of healthy compounds. So far, scientific research has mainly focused on its polyphenol content, but given the impressive number of bioactivities shown by grape pomace, it is not unlikely that, besides polyphenols, additional metabolites, so far undetected, may be involved. In order to verify such hypothesis, an in-depth chemical analysis of Aglianico (Vitis vinifera) grape pomace was conducted by NMR and LC-MS/MS. In addition to a number of polyphenols, a remarkable concentration of oleanolic acid (0.45 mg/g - fresh weight) was determined in the analyzed material. Oleanolic acid is a natural triterpenoid showing many bioactivities including antitumor, anti-inflammatory, antibiotic and antiviral properties. Also, it was proven a potential antidiabetic molecule in Type1 Diabetes rats. Hence, its influence on the mitochondrial and glucose uptake activities of C2C12 myoblast was here assessed, thus supporting oleanolic acid as a promising antidiabetic metabolite.
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title_short	Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace
url	https://doi.org/10.1016/j.jff.2023.105548 https://doaj.org/article/d6c5aa45b381448db307de11a3f84b6f http://www.sciencedirect.com/science/article/pii/S1756464623001482 https://doaj.org/toc/1756-4646
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Oleanolic acid: A promising antidiabetic metabolite detected in Aglianico grape pomace

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