Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L.

The fruit of <i<Morus alba</i< L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been re...
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Autor*in:	Tae Sik Sung [verfasserIn] Seung-Bum Ryoo [verfasserIn] Chang-Hyun Lee [verfasserIn] Seon-Min Choi [verfasserIn] Joo-Won Nam [verfasserIn] Hyun-Bok Kim [verfasserIn] Ji young Lee [verfasserIn] Jung-Dae Lim [verfasserIn] Kyu Joo Park [verfasserIn] Hyun-Tai Lee [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	intestinal transit mulberry fruit myogenic contraction neurogenic contraction prokinetic

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 15(2023), 8, p 1889
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:8, p 1889

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu15081889

Katalog-ID:	DOAJ089797337

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spelling	10.3390/nu15081889 doi (DE-627)DOAJ089797337 (DE-599)DOAJ5d545779bb5d45c8a7d126345e4b7d46 DE-627 ger DE-627 rakwb eng TX341-641 Tae Sik Sung verfasserin aut Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The fruit of <i<Morus alba</i< L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR. intestinal transit <i<Morus alba</i< mulberry fruit myogenic contraction neurogenic contraction prokinetic Nutrition. Foods and food supply Seung-Bum Ryoo verfasserin aut Chang-Hyun Lee verfasserin aut Seon-Min Choi verfasserin aut Joo-Won Nam verfasserin aut Hyun-Bok Kim verfasserin aut Ji young Lee verfasserin aut Jung-Dae Lim verfasserin aut Kyu Joo Park verfasserin aut Hyun-Tai Lee verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 8, p 1889 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:8, p 1889 https://doi.org/10.3390/nu15081889 kostenfrei https://doaj.org/article/5d545779bb5d45c8a7d126345e4b7d46 kostenfrei https://www.mdpi.com/2072-6643/15/8/1889 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 1889
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allfieldsGer	10.3390/nu15081889 doi (DE-627)DOAJ089797337 (DE-599)DOAJ5d545779bb5d45c8a7d126345e4b7d46 DE-627 ger DE-627 rakwb eng TX341-641 Tae Sik Sung verfasserin aut Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The fruit of <i<Morus alba</i< L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR. intestinal transit <i<Morus alba</i< mulberry fruit myogenic contraction neurogenic contraction prokinetic Nutrition. Foods and food supply Seung-Bum Ryoo verfasserin aut Chang-Hyun Lee verfasserin aut Seon-Min Choi verfasserin aut Joo-Won Nam verfasserin aut Hyun-Bok Kim verfasserin aut Ji young Lee verfasserin aut Jung-Dae Lim verfasserin aut Kyu Joo Park verfasserin aut Hyun-Tai Lee verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 8, p 1889 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:8, p 1889 https://doi.org/10.3390/nu15081889 kostenfrei https://doaj.org/article/5d545779bb5d45c8a7d126345e4b7d46 kostenfrei https://www.mdpi.com/2072-6643/15/8/1889 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 1889
allfieldsSound	10.3390/nu15081889 doi (DE-627)DOAJ089797337 (DE-599)DOAJ5d545779bb5d45c8a7d126345e4b7d46 DE-627 ger DE-627 rakwb eng TX341-641 Tae Sik Sung verfasserin aut Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L. 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The fruit of <i<Morus alba</i< L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR. intestinal transit <i<Morus alba</i< mulberry fruit myogenic contraction neurogenic contraction prokinetic Nutrition. Foods and food supply Seung-Bum Ryoo verfasserin aut Chang-Hyun Lee verfasserin aut Seon-Min Choi verfasserin aut Joo-Won Nam verfasserin aut Hyun-Bok Kim verfasserin aut Ji young Lee verfasserin aut Jung-Dae Lim verfasserin aut Kyu Joo Park verfasserin aut Hyun-Tai Lee verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 8, p 1889 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:8, p 1889 https://doi.org/10.3390/nu15081889 kostenfrei https://doaj.org/article/5d545779bb5d45c8a7d126345e4b7d46 kostenfrei https://www.mdpi.com/2072-6643/15/8/1889 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 1889
language	English
source	In Nutrients 15(2023), 8, p 1889 volume:15 year:2023 number:8, p 1889
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authorswithroles_txt_mv	Tae Sik Sung @@aut@@ Seung-Bum Ryoo @@aut@@ Chang-Hyun Lee @@aut@@ Seon-Min Choi @@aut@@ Joo-Won Nam @@aut@@ Hyun-Bok Kim @@aut@@ Ji young Lee @@aut@@ Jung-Dae Lim @@aut@@ Kyu Joo Park @@aut@@ Hyun-Tai Lee @@aut@@
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callnumber-first	T - Technology
author	Tae Sik Sung
spellingShingle	Tae Sik Sung misc TX341-641 misc intestinal transit misc <i<Morus alba</i< misc mulberry fruit misc myogenic contraction misc neurogenic contraction misc prokinetic misc Nutrition. Foods and food supply Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L.
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topic_title	TX341-641 Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L. intestinal transit <i<Morus alba</i< mulberry fruit myogenic contraction neurogenic contraction prokinetic
topic	misc TX341-641 misc intestinal transit misc <i<Morus alba</i< misc mulberry fruit misc myogenic contraction misc neurogenic contraction misc prokinetic misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc intestinal transit misc <i<Morus alba</i< misc mulberry fruit misc myogenic contraction misc neurogenic contraction misc prokinetic misc Nutrition. Foods and food supply
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title	Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L.
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title_full	Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L.
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title_sort	prokinetic activity of mulberry fruit, <i<morus alba</i< l.
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title_auth	Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L.
abstract	The fruit of <i<Morus alba</i< L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR.
abstractGer	The fruit of <i<Morus alba</i< L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR.
abstract_unstemmed	The fruit of <i<Morus alba</i< L. (MAF) has been consumed as a food worldwide. MAF has also been widely used in traditional medicine for thousands of years in East Asia, and its diverse bioactivities have been reported in numerous publications. However, no prokinetic activity has been reported for MAF or its components. In the present study, therefore, we investigated the effects of MAF on gastrointestinal motor function by measuring the intestinal transit rate (ITR) of Evans blue in mice in vivo. The ITR values accelerated by MAF were significantly higher than those accelerated by cisapride or metoclopramide, suggesting that MAF has potential as a new prokinetic agent to replace cisapride and metoclopramide. We also investigated the effects of MAF on myogenic and neurogenic contractions in human intestinal smooth muscles by measuring spontaneous contractions of smooth muscle strips, smooth muscle contractions induced by neural stimulation, and migrating motor complexes from intestinal segments in the human ileum and sigmoid colon in situ. MAF increased both myogenic and neurogenic contractions to enhance ileal and colonic motility in the human intestine. Taken together, these results indicate that MAF enhanced intestinal motility by increasing both myogenic and neurogenic contractions, thereby accelerating the ITR.
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container_issue	8, p 1889
title_short	Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L.
url	https://doi.org/10.3390/nu15081889 https://doaj.org/article/5d545779bb5d45c8a7d126345e4b7d46 https://www.mdpi.com/2072-6643/15/8/1889 https://doaj.org/toc/2072-6643
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up_date	2024-07-04T00:41:35.132Z
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Prokinetic Activity of Mulberry Fruit, <i<Morus alba</i< L.

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