The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives

One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anti...
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Autor*in:	Giulia Coffetti [verfasserIn] Martina Moraschi [verfasserIn] Giorgio Facchetti [verfasserIn] Isabella Rimoldi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	platinum (II) complexes platinum (IV) complexes anticancer agents orphan tumors resistance phenomena

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 28(2023), 8, p 3407
Übergeordnetes Werk:	volume:28 ; year:2023 ; number:8, p 3407

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules28083407

Katalog-ID:	DOAJ089802446

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allfieldsSound	10.3390/molecules28083407 doi (DE-627)DOAJ089802446 (DE-599)DOAJf16f12b7b03243ed89f0a5967e810ec6 DE-627 ger DE-627 rakwb eng QD241-441 Giulia Coffetti verfasserin aut The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the research studies reported herein focus on the capability of some platinum-based anticancer agents to bypass resistance to chemotherapy, which is typical of well-known drugs such as cisplatin. Regarding platinum (II) complexes, this review deals with complexes in trans conformation; complexes containing bioactive ligands, as well as those that are differently charged, all experience a different reaction mechanism compared with cisplatin. Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli. platinum (II) complexes platinum (IV) complexes anticancer agents orphan tumors resistance phenomena Organic chemistry Martina Moraschi verfasserin aut Giorgio Facchetti verfasserin aut Isabella Rimoldi verfasserin aut In Molecules MDPI AG, 2003 28(2023), 8, p 3407 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:8, p 3407 https://doi.org/10.3390/molecules28083407 kostenfrei https://doaj.org/article/f16f12b7b03243ed89f0a5967e810ec6 kostenfrei https://www.mdpi.com/1420-3049/28/8/3407 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 8, p 3407
language	English
source	In Molecules 28(2023), 8, p 3407 volume:28 year:2023 number:8, p 3407
sourceStr	In Molecules 28(2023), 8, p 3407 volume:28 year:2023 number:8, p 3407
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	platinum (II) complexes platinum (IV) complexes anticancer agents orphan tumors resistance phenomena Organic chemistry
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container_title	Molecules
authorswithroles_txt_mv	Giulia Coffetti @@aut@@ Martina Moraschi @@aut@@ Giorgio Facchetti @@aut@@ Isabella Rimoldi @@aut@@
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callnumber-first	Q - Science
author	Giulia Coffetti
spellingShingle	Giulia Coffetti misc QD241-441 misc platinum (II) complexes misc platinum (IV) complexes misc anticancer agents misc orphan tumors misc resistance phenomena misc Organic chemistry The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives
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topic_title	QD241-441 The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives platinum (II) complexes platinum (IV) complexes anticancer agents orphan tumors resistance phenomena
topic	misc QD241-441 misc platinum (II) complexes misc platinum (IV) complexes misc anticancer agents misc orphan tumors misc resistance phenomena misc Organic chemistry
topic_unstemmed	misc QD241-441 misc platinum (II) complexes misc platinum (IV) complexes misc anticancer agents misc orphan tumors misc resistance phenomena misc Organic chemistry
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title_sort	challenging treatment of cisplatin-resistant tumors: state of the art and future perspectives
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title_auth	The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives
abstract	One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the research studies reported herein focus on the capability of some platinum-based anticancer agents to bypass resistance to chemotherapy, which is typical of well-known drugs such as cisplatin. Regarding platinum (II) complexes, this review deals with complexes in trans conformation; complexes containing bioactive ligands, as well as those that are differently charged, all experience a different reaction mechanism compared with cisplatin. Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli.
abstractGer	One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the research studies reported herein focus on the capability of some platinum-based anticancer agents to bypass resistance to chemotherapy, which is typical of well-known drugs such as cisplatin. Regarding platinum (II) complexes, this review deals with complexes in trans conformation; complexes containing bioactive ligands, as well as those that are differently charged, all experience a different reaction mechanism compared with cisplatin. Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli.
abstract_unstemmed	One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the research studies reported herein focus on the capability of some platinum-based anticancer agents to bypass resistance to chemotherapy, which is typical of well-known drugs such as cisplatin. Regarding platinum (II) complexes, this review deals with complexes in trans conformation; complexes containing bioactive ligands, as well as those that are differently charged, all experience a different reaction mechanism compared with cisplatin. Regarding platinum (IV) compounds, the focus was on complexes with biologically active ancillary ligands that exert a synergistic effect with platinum (II)-active complexes upon reduction, or those for which controllable activation can be realized thanks to intracellular stimuli.
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title_short	The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives
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