Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone

Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their de...
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Autor*in:	Kaihua Wang [verfasserIn] Beibei Wang [verfasserIn] Henan Ma [verfasserIn] Ziwen Wang [verfasserIn] Yuxiu Liu [verfasserIn] Qingmin Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	naphthoquinone analogues plumbagin juglone fungicidal activity lead discovery structural diversity derivation

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 28(2023), 8, p 3328
Übergeordnetes Werk:	volume:28 ; year:2023 ; number:8, p 3328

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules28083328

Katalog-ID:	DOAJ08980323X

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author	Kaihua Wang
spellingShingle	Kaihua Wang misc QD241-441 misc naphthoquinone analogues misc plumbagin misc juglone misc fungicidal activity misc lead discovery misc structural diversity derivation misc Organic chemistry Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone
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topic_title	QD241-441 Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone naphthoquinone analogues plumbagin juglone fungicidal activity lead discovery structural diversity derivation
topic	misc QD241-441 misc naphthoquinone analogues misc plumbagin misc juglone misc fungicidal activity misc lead discovery misc structural diversity derivation misc Organic chemistry
topic_unstemmed	misc QD241-441 misc naphthoquinone analogues misc plumbagin misc juglone misc fungicidal activity misc lead discovery misc structural diversity derivation misc Organic chemistry
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title	Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone
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title_sort	natural products for pesticides discovery: structural diversity derivation and biological activities of naphthoquinones plumbagin and juglone
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title_auth	Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone
abstract	Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection.
abstractGer	Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection.
abstract_unstemmed	Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection.
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title_short	Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone
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Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. 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Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone

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