Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their de...
Ausführliche Beschreibung
Autor*in: |
Kaihua Wang [verfasserIn] Beibei Wang [verfasserIn] Henan Ma [verfasserIn] Ziwen Wang [verfasserIn] Yuxiu Liu [verfasserIn] Qingmin Wang [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: Molecules - MDPI AG, 2003, 28(2023), 8, p 3328 |
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Übergeordnetes Werk: |
volume:28 ; year:2023 ; number:8, p 3328 |
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DOI / URN: |
10.3390/molecules28083328 |
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Katalog-ID: |
DOAJ08980323X |
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10.3390/molecules28083328 doi (DE-627)DOAJ08980323X (DE-599)DOAJ85de0f27b6434e19bd5409d703361db3 DE-627 ger DE-627 rakwb eng QD241-441 Kaihua Wang verfasserin aut Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. naphthoquinone analogues plumbagin juglone fungicidal activity lead discovery structural diversity derivation Organic chemistry Beibei Wang verfasserin aut Henan Ma verfasserin aut Ziwen Wang verfasserin aut Yuxiu Liu verfasserin aut Qingmin Wang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 8, p 3328 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:8, p 3328 https://doi.org/10.3390/molecules28083328 kostenfrei https://doaj.org/article/85de0f27b6434e19bd5409d703361db3 kostenfrei https://www.mdpi.com/1420-3049/28/8/3328 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 8, p 3328 |
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10.3390/molecules28083328 doi (DE-627)DOAJ08980323X (DE-599)DOAJ85de0f27b6434e19bd5409d703361db3 DE-627 ger DE-627 rakwb eng QD241-441 Kaihua Wang verfasserin aut Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. naphthoquinone analogues plumbagin juglone fungicidal activity lead discovery structural diversity derivation Organic chemistry Beibei Wang verfasserin aut Henan Ma verfasserin aut Ziwen Wang verfasserin aut Yuxiu Liu verfasserin aut Qingmin Wang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 8, p 3328 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:8, p 3328 https://doi.org/10.3390/molecules28083328 kostenfrei https://doaj.org/article/85de0f27b6434e19bd5409d703361db3 kostenfrei https://www.mdpi.com/1420-3049/28/8/3328 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 8, p 3328 |
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10.3390/molecules28083328 doi (DE-627)DOAJ08980323X (DE-599)DOAJ85de0f27b6434e19bd5409d703361db3 DE-627 ger DE-627 rakwb eng QD241-441 Kaihua Wang verfasserin aut Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. naphthoquinone analogues plumbagin juglone fungicidal activity lead discovery structural diversity derivation Organic chemistry Beibei Wang verfasserin aut Henan Ma verfasserin aut Ziwen Wang verfasserin aut Yuxiu Liu verfasserin aut Qingmin Wang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 8, p 3328 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:8, p 3328 https://doi.org/10.3390/molecules28083328 kostenfrei https://doaj.org/article/85de0f27b6434e19bd5409d703361db3 kostenfrei https://www.mdpi.com/1420-3049/28/8/3328 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 8, p 3328 |
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10.3390/molecules28083328 doi (DE-627)DOAJ08980323X (DE-599)DOAJ85de0f27b6434e19bd5409d703361db3 DE-627 ger DE-627 rakwb eng QD241-441 Kaihua Wang verfasserin aut Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. naphthoquinone analogues plumbagin juglone fungicidal activity lead discovery structural diversity derivation Organic chemistry Beibei Wang verfasserin aut Henan Ma verfasserin aut Ziwen Wang verfasserin aut Yuxiu Liu verfasserin aut Qingmin Wang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 8, p 3328 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:8, p 3328 https://doi.org/10.3390/molecules28083328 kostenfrei https://doaj.org/article/85de0f27b6434e19bd5409d703361db3 kostenfrei https://www.mdpi.com/1420-3049/28/8/3328 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 8, p 3328 |
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10.3390/molecules28083328 doi (DE-627)DOAJ08980323X (DE-599)DOAJ85de0f27b6434e19bd5409d703361db3 DE-627 ger DE-627 rakwb eng QD241-441 Kaihua Wang verfasserin aut Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. naphthoquinone analogues plumbagin juglone fungicidal activity lead discovery structural diversity derivation Organic chemistry Beibei Wang verfasserin aut Henan Ma verfasserin aut Ziwen Wang verfasserin aut Yuxiu Liu verfasserin aut Qingmin Wang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 8, p 3328 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:8, p 3328 https://doi.org/10.3390/molecules28083328 kostenfrei https://doaj.org/article/85de0f27b6434e19bd5409d703361db3 kostenfrei https://www.mdpi.com/1420-3049/28/8/3328 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 8, p 3328 |
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Natural Products for Pesticides Discovery: Structural Diversity Derivation and Biological Activities of Naphthoquinones Plumbagin and Juglone |
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Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. |
abstractGer |
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. |
abstract_unstemmed |
Plant diseases and insect pests seriously affect the yield and quality of crops and are difficult to control. Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. In current study, plumbagin and juglone were discovered as parent structures, which lays a foundation for their application in plant protection. |
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Natural products are an important source for the discovery of new pesticides. In this work, naphthoquinones plumbagin and juglone were selected as parent structures, and a series of their derivatives were designed, synthesized and evaluated for their fungicidal activities, antiviral activities and insecticidal activities. We found that the naphthoquinones have broad-spectrum anti-fungal activities against 14 types of fungus for the first time. Some of the naphthoquinones showed higher fungicidal activities than pyrimethanil. Compounds <b<I</b<, <b<I-1e</b< and <b<II-1a</b< emerged as new anti-fungal lead compounds with excellent fungicidal activities (EC<sub<50</sub< values: 11.35–17.70 µg/mL) against <i<Cercospora</i<, <i<arachidicola Hori</i<. Some compounds also displayed good to excellent antiviral activities against the tobacco mosaic virus (TMV). Compounds <b<I-1f</b< and <b<II-1f</b< showed similar level of anti-TMV activities with ribavirin, and could be used as new antiviral candidates. These compound also exhibited good to excellent insecticidal activities. Compounds <b<II-1d</b< and <b<III-1c</b< displayed a similar level of insecticidal activities with matrine, hexaflumuron and rotenone against <i<Plutella xylostella</i<. 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