Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit

The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in...
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Autor*in:	Simone Mornese Pinna [verfasserIn] Iago Sousa Casasnovas [verfasserIn] María Olmedo [verfasserIn] Marina Machado [verfasserIn] Miriam Juàrez Fernández [verfasserIn] Carolina Devesa-Cordero [verfasserIn] Alicia Galar [verfasserIn] Ana Alvarez-Uria [verfasserIn] Francisco Fernández-Avilés [verfasserIn] Jorge García Carreño [verfasserIn] Manuel Martínez-Sellés [verfasserIn] Francesco Giuseppe De Rosa [verfasserIn] Silvia Corcione [verfasserIn] Emilio Bouza [verfasserIn] Patricia Muñoz [verfasserIn] Maricela Valerio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections

Übergeordnetes Werk:	In: Microorganisms - MDPI AG, 2013, 11(2023), 4, p 1079
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:4, p 1079

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/microorganisms11041079

Katalog-ID:	DOAJ089805089

Internformat


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allfields	10.3390/microorganisms11041079 doi (DE-627)DOAJ089805089 (DE-599)DOAJeeaef5bdbc4b4b3c98e2b8e2d11c92d0 DE-627 ger DE-627 rakwb eng QH301-705.5 Simone Mornese Pinna verfasserin aut Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients. ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections Biology (General) Iago Sousa Casasnovas verfasserin aut María Olmedo verfasserin aut Marina Machado verfasserin aut Miriam Juàrez Fernández verfasserin aut Carolina Devesa-Cordero verfasserin aut Alicia Galar verfasserin aut Ana Alvarez-Uria verfasserin aut Francisco Fernández-Avilés verfasserin aut Jorge García Carreño verfasserin aut Manuel Martínez-Sellés verfasserin aut Francesco Giuseppe De Rosa verfasserin aut Silvia Corcione verfasserin aut Emilio Bouza verfasserin aut Patricia Muñoz verfasserin aut Maricela Valerio verfasserin aut In Microorganisms MDPI AG, 2013 11(2023), 4, p 1079 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:11 year:2023 number:4, p 1079 https://doi.org/10.3390/microorganisms11041079 kostenfrei https://doaj.org/article/eeaef5bdbc4b4b3c98e2b8e2d11c92d0 kostenfrei https://www.mdpi.com/2076-2607/11/4/1079 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 4, p 1079
spelling	10.3390/microorganisms11041079 doi (DE-627)DOAJ089805089 (DE-599)DOAJeeaef5bdbc4b4b3c98e2b8e2d11c92d0 DE-627 ger DE-627 rakwb eng QH301-705.5 Simone Mornese Pinna verfasserin aut Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients. ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections Biology (General) Iago Sousa Casasnovas verfasserin aut María Olmedo verfasserin aut Marina Machado verfasserin aut Miriam Juàrez Fernández verfasserin aut Carolina Devesa-Cordero verfasserin aut Alicia Galar verfasserin aut Ana Alvarez-Uria verfasserin aut Francisco Fernández-Avilés verfasserin aut Jorge García Carreño verfasserin aut Manuel Martínez-Sellés verfasserin aut Francesco Giuseppe De Rosa verfasserin aut Silvia Corcione verfasserin aut Emilio Bouza verfasserin aut Patricia Muñoz verfasserin aut Maricela Valerio verfasserin aut In Microorganisms MDPI AG, 2013 11(2023), 4, p 1079 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:11 year:2023 number:4, p 1079 https://doi.org/10.3390/microorganisms11041079 kostenfrei https://doaj.org/article/eeaef5bdbc4b4b3c98e2b8e2d11c92d0 kostenfrei https://www.mdpi.com/2076-2607/11/4/1079 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 4, p 1079
allfields_unstemmed	10.3390/microorganisms11041079 doi (DE-627)DOAJ089805089 (DE-599)DOAJeeaef5bdbc4b4b3c98e2b8e2d11c92d0 DE-627 ger DE-627 rakwb eng QH301-705.5 Simone Mornese Pinna verfasserin aut Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients. ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections Biology (General) Iago Sousa Casasnovas verfasserin aut María Olmedo verfasserin aut Marina Machado verfasserin aut Miriam Juàrez Fernández verfasserin aut Carolina Devesa-Cordero verfasserin aut Alicia Galar verfasserin aut Ana Alvarez-Uria verfasserin aut Francisco Fernández-Avilés verfasserin aut Jorge García Carreño verfasserin aut Manuel Martínez-Sellés verfasserin aut Francesco Giuseppe De Rosa verfasserin aut Silvia Corcione verfasserin aut Emilio Bouza verfasserin aut Patricia Muñoz verfasserin aut Maricela Valerio verfasserin aut In Microorganisms MDPI AG, 2013 11(2023), 4, p 1079 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:11 year:2023 number:4, p 1079 https://doi.org/10.3390/microorganisms11041079 kostenfrei https://doaj.org/article/eeaef5bdbc4b4b3c98e2b8e2d11c92d0 kostenfrei https://www.mdpi.com/2076-2607/11/4/1079 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 4, p 1079
allfieldsGer	10.3390/microorganisms11041079 doi (DE-627)DOAJ089805089 (DE-599)DOAJeeaef5bdbc4b4b3c98e2b8e2d11c92d0 DE-627 ger DE-627 rakwb eng QH301-705.5 Simone Mornese Pinna verfasserin aut Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients. ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections Biology (General) Iago Sousa Casasnovas verfasserin aut María Olmedo verfasserin aut Marina Machado verfasserin aut Miriam Juàrez Fernández verfasserin aut Carolina Devesa-Cordero verfasserin aut Alicia Galar verfasserin aut Ana Alvarez-Uria verfasserin aut Francisco Fernández-Avilés verfasserin aut Jorge García Carreño verfasserin aut Manuel Martínez-Sellés verfasserin aut Francesco Giuseppe De Rosa verfasserin aut Silvia Corcione verfasserin aut Emilio Bouza verfasserin aut Patricia Muñoz verfasserin aut Maricela Valerio verfasserin aut In Microorganisms MDPI AG, 2013 11(2023), 4, p 1079 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:11 year:2023 number:4, p 1079 https://doi.org/10.3390/microorganisms11041079 kostenfrei https://doaj.org/article/eeaef5bdbc4b4b3c98e2b8e2d11c92d0 kostenfrei https://www.mdpi.com/2076-2607/11/4/1079 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 4, p 1079
allfieldsSound	10.3390/microorganisms11041079 doi (DE-627)DOAJ089805089 (DE-599)DOAJeeaef5bdbc4b4b3c98e2b8e2d11c92d0 DE-627 ger DE-627 rakwb eng QH301-705.5 Simone Mornese Pinna verfasserin aut Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients. ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections Biology (General) Iago Sousa Casasnovas verfasserin aut María Olmedo verfasserin aut Marina Machado verfasserin aut Miriam Juàrez Fernández verfasserin aut Carolina Devesa-Cordero verfasserin aut Alicia Galar verfasserin aut Ana Alvarez-Uria verfasserin aut Francisco Fernández-Avilés verfasserin aut Jorge García Carreño verfasserin aut Manuel Martínez-Sellés verfasserin aut Francesco Giuseppe De Rosa verfasserin aut Silvia Corcione verfasserin aut Emilio Bouza verfasserin aut Patricia Muñoz verfasserin aut Maricela Valerio verfasserin aut In Microorganisms MDPI AG, 2013 11(2023), 4, p 1079 (DE-627)750370696 (DE-600)2720891-6 20762607 nnns volume:11 year:2023 number:4, p 1079 https://doi.org/10.3390/microorganisms11041079 kostenfrei https://doaj.org/article/eeaef5bdbc4b4b3c98e2b8e2d11c92d0 kostenfrei https://www.mdpi.com/2076-2607/11/4/1079 kostenfrei https://doaj.org/toc/2076-2607 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023 4, p 1079
language	English
source	In Microorganisms 11(2023), 4, p 1079 volume:11 year:2023 number:4, p 1079
sourceStr	In Microorganisms 11(2023), 4, p 1079 volume:11 year:2023 number:4, p 1079
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections Biology (General)
isfreeaccess_bool	true
container_title	Microorganisms
authorswithroles_txt_mv	Simone Mornese Pinna @@aut@@ Iago Sousa Casasnovas @@aut@@ María Olmedo @@aut@@ Marina Machado @@aut@@ Miriam Juàrez Fernández @@aut@@ Carolina Devesa-Cordero @@aut@@ Alicia Galar @@aut@@ Ana Alvarez-Uria @@aut@@ Francisco Fernández-Avilés @@aut@@ Jorge García Carreño @@aut@@ Manuel Martínez-Sellés @@aut@@ Francesco Giuseppe De Rosa @@aut@@ Silvia Corcione @@aut@@ Emilio Bouza @@aut@@ Patricia Muñoz @@aut@@ Maricela Valerio @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	750370696
id	DOAJ089805089
language_de	englisch
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callnumber-first	Q - Science
author	Simone Mornese Pinna
spellingShingle	Simone Mornese Pinna misc QH301-705.5 misc ECMO misc venoarterial extracorporeal membrane oxygenation misc nosocomial infections misc cardiac intensive care unit misc cardiovascular infections misc Biology (General) Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit
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topic_title	QH301-705.5 Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit ECMO venoarterial extracorporeal membrane oxygenation nosocomial infections cardiac intensive care unit cardiovascular infections
topic	misc QH301-705.5 misc ECMO misc venoarterial extracorporeal membrane oxygenation misc nosocomial infections misc cardiac intensive care unit misc cardiovascular infections misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc ECMO misc venoarterial extracorporeal membrane oxygenation misc nosocomial infections misc cardiac intensive care unit misc cardiovascular infections misc Biology (General)
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title	Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit
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title_full	Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit
author_sort	Simone Mornese Pinna
journal	Microorganisms
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author_browse	Simone Mornese Pinna Iago Sousa Casasnovas María Olmedo Marina Machado Miriam Juàrez Fernández Carolina Devesa-Cordero Alicia Galar Ana Alvarez-Uria Francisco Fernández-Avilés Jorge García Carreño Manuel Martínez-Sellés Francesco Giuseppe De Rosa Silvia Corcione Emilio Bouza Patricia Muñoz Maricela Valerio
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doi_str_mv	10.3390/microorganisms11041079
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title_sort	nosocomial infections in adult patients supported by extracorporeal membrane oxygenation in a cardiac intensive care unit
callnumber	QH301-705.5
title_auth	Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit
abstract	The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients.
abstractGer	The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients.
abstract_unstemmed	The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for <48 h. From 69 patients treated with VA-ECMO <48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (<i<p</i< = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, <i<p</i< = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. <b<Conclusions:</b< Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients.
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title_short	Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit
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author2Str	Iago Sousa Casasnovas María Olmedo Marina Machado Miriam Juàrez Fernández Carolina Devesa-Cordero Alicia Galar Ana Alvarez-Uria Francisco Fernández-Avilés Jorge García Carreño Manuel Martínez-Sellés Francesco Giuseppe De Rosa Silvia Corcione Emilio Bouza Patricia Muñoz Maricela Valerio
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Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit

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