The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders

The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. Over the years, this pat...
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Autor*in:	Giuseppina Caiazzo [verfasserIn] Anna Caiazzo [verfasserIn] Maddalena Napolitano [verfasserIn] Matteo Megna [verfasserIn] Luca Potestio [verfasserIn] Luigi Fornaro [verfasserIn] Melania Parisi [verfasserIn] Maria Antonietta Luciano [verfasserIn] Angelo Ruggiero [verfasserIn] Anna Testa [verfasserIn] Fabiana Castiglione [verfasserIn] Cataldo Patruno [verfasserIn] Maria Quaranta [verfasserIn] Gabriella Fabbrocini [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	JAK/STAT signaling pathway JAK-STAT inhibitors inflammatory disorders atopic dermatitis psoriasis psoriatic arthritis

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 8, p 2865
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:8, p 2865

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12082865

Katalog-ID:	DOAJ089836626

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allfieldsSound	10.3390/jcm12082865 doi (DE-627)DOAJ089836626 (DE-599)DOAJ265c8d3bc1534aa3a364bbc2516b7948 DE-627 ger DE-627 rakwb eng Giuseppina Caiazzo verfasserin aut The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. Over the years, this pathway has been heavily investigated due to its key role in the pathogeneses of several chronic inflammatory conditions, e.g., psoriasis, atopic dermatitis (AD), and inflammatory bowel diseases (IBDs). Nevertheless, the impact of this pathway on the pathogenesis of inflammatory conditions remains unclear. This review describes the role of the JAK/STAT signaling pathway in the pathogenesis of inflammatory diseases such as psoriasis (Pso), psoriatic arthritis (PsA), AD, and IBD with a focus on ulcerative colitis (UC) and briefly resumes the use of JAK inhibitors in their clinical management. JAK/STAT signaling pathway JAK-STAT inhibitors inflammatory disorders atopic dermatitis psoriasis psoriatic arthritis Medicine R Anna Caiazzo verfasserin aut Maddalena Napolitano verfasserin aut Matteo Megna verfasserin aut Luca Potestio verfasserin aut Luigi Fornaro verfasserin aut Melania Parisi verfasserin aut Maria Antonietta Luciano verfasserin aut Angelo Ruggiero verfasserin aut Anna Testa verfasserin aut Fabiana Castiglione verfasserin aut Cataldo Patruno verfasserin aut Maria Quaranta verfasserin aut Gabriella Fabbrocini verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 8, p 2865 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:8, p 2865 https://doi.org/10.3390/jcm12082865 kostenfrei https://doaj.org/article/265c8d3bc1534aa3a364bbc2516b7948 kostenfrei https://www.mdpi.com/2077-0383/12/8/2865 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 8, p 2865
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author	Giuseppina Caiazzo
spellingShingle	Giuseppina Caiazzo misc JAK/STAT signaling pathway misc JAK-STAT inhibitors misc inflammatory disorders misc atopic dermatitis misc psoriasis misc psoriatic arthritis misc Medicine misc R The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders
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topic_title	The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders JAK/STAT signaling pathway JAK-STAT inhibitors inflammatory disorders atopic dermatitis psoriasis psoriatic arthritis
topic	misc JAK/STAT signaling pathway misc JAK-STAT inhibitors misc inflammatory disorders misc atopic dermatitis misc psoriasis misc psoriatic arthritis misc Medicine misc R
topic_unstemmed	misc JAK/STAT signaling pathway misc JAK-STAT inhibitors misc inflammatory disorders misc atopic dermatitis misc psoriasis misc psoriatic arthritis misc Medicine misc R
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title	The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders
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title_sort	use of jak/stat inhibitors in chronic inflammatory disorders
title_auth	The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders
abstract	The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. Over the years, this pathway has been heavily investigated due to its key role in the pathogeneses of several chronic inflammatory conditions, e.g., psoriasis, atopic dermatitis (AD), and inflammatory bowel diseases (IBDs). Nevertheless, the impact of this pathway on the pathogenesis of inflammatory conditions remains unclear. This review describes the role of the JAK/STAT signaling pathway in the pathogenesis of inflammatory diseases such as psoriasis (Pso), psoriatic arthritis (PsA), AD, and IBD with a focus on ulcerative colitis (UC) and briefly resumes the use of JAK inhibitors in their clinical management.
abstractGer	The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. Over the years, this pathway has been heavily investigated due to its key role in the pathogeneses of several chronic inflammatory conditions, e.g., psoriasis, atopic dermatitis (AD), and inflammatory bowel diseases (IBDs). Nevertheless, the impact of this pathway on the pathogenesis of inflammatory conditions remains unclear. This review describes the role of the JAK/STAT signaling pathway in the pathogenesis of inflammatory diseases such as psoriasis (Pso), psoriatic arthritis (PsA), AD, and IBD with a focus on ulcerative colitis (UC) and briefly resumes the use of JAK inhibitors in their clinical management.
abstract_unstemmed	The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in orchestrating immune and inflammatory responses, and it is essential for a wide range of cellular processes, including differentiation, cell growth, and apoptosis. Over the years, this pathway has been heavily investigated due to its key role in the pathogeneses of several chronic inflammatory conditions, e.g., psoriasis, atopic dermatitis (AD), and inflammatory bowel diseases (IBDs). Nevertheless, the impact of this pathway on the pathogenesis of inflammatory conditions remains unclear. This review describes the role of the JAK/STAT signaling pathway in the pathogenesis of inflammatory diseases such as psoriasis (Pso), psoriatic arthritis (PsA), AD, and IBD with a focus on ulcerative colitis (UC) and briefly resumes the use of JAK inhibitors in their clinical management.
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title_short	The Use of JAK/STAT Inhibitors in Chronic Inflammatory Disorders
url	https://doi.org/10.3390/jcm12082865 https://doaj.org/article/265c8d3bc1534aa3a364bbc2516b7948 https://www.mdpi.com/2077-0383/12/8/2865 https://doaj.org/toc/2077-0383
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