Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets
Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we ev...
Ausführliche Beschreibung
Autor*in: |
Valeria Orrù [verfasserIn] Francesca Virdis [verfasserIn] Michele Marongiu [verfasserIn] Valentina Serra [verfasserIn] David Schlessinger [verfasserIn] Marcella Devoto [verfasserIn] Francesco Cucca [verfasserIn] Edoardo Fiorillo [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 8, p 7183 |
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Übergeordnetes Werk: |
volume:24 ; year:2023 ; number:8, p 7183 |
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Link aufrufen |
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DOI / URN: |
10.3390/ijms24087183 |
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Katalog-ID: |
DOAJ089845498 |
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10.3390/ijms24087183 doi (DE-627)DOAJ089845498 (DE-599)DOAJa69b303fda604ae691e5b65ebcf52455 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Valeria Orrù verfasserin aut Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. extracellular vesicles flow cytometry GWAS Biology (General) Chemistry Francesca Virdis verfasserin aut Michele Marongiu verfasserin aut Valentina Serra verfasserin aut David Schlessinger verfasserin aut Marcella Devoto verfasserin aut Francesco Cucca verfasserin aut Edoardo Fiorillo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 8, p 7183 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:8, p 7183 https://doi.org/10.3390/ijms24087183 kostenfrei https://doaj.org/article/a69b303fda604ae691e5b65ebcf52455 kostenfrei https://www.mdpi.com/1422-0067/24/8/7183 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 8, p 7183 |
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10.3390/ijms24087183 doi (DE-627)DOAJ089845498 (DE-599)DOAJa69b303fda604ae691e5b65ebcf52455 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Valeria Orrù verfasserin aut Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. extracellular vesicles flow cytometry GWAS Biology (General) Chemistry Francesca Virdis verfasserin aut Michele Marongiu verfasserin aut Valentina Serra verfasserin aut David Schlessinger verfasserin aut Marcella Devoto verfasserin aut Francesco Cucca verfasserin aut Edoardo Fiorillo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 8, p 7183 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:8, p 7183 https://doi.org/10.3390/ijms24087183 kostenfrei https://doaj.org/article/a69b303fda604ae691e5b65ebcf52455 kostenfrei https://www.mdpi.com/1422-0067/24/8/7183 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 8, p 7183 |
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10.3390/ijms24087183 doi (DE-627)DOAJ089845498 (DE-599)DOAJa69b303fda604ae691e5b65ebcf52455 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Valeria Orrù verfasserin aut Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. extracellular vesicles flow cytometry GWAS Biology (General) Chemistry Francesca Virdis verfasserin aut Michele Marongiu verfasserin aut Valentina Serra verfasserin aut David Schlessinger verfasserin aut Marcella Devoto verfasserin aut Francesco Cucca verfasserin aut Edoardo Fiorillo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 8, p 7183 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:8, p 7183 https://doi.org/10.3390/ijms24087183 kostenfrei https://doaj.org/article/a69b303fda604ae691e5b65ebcf52455 kostenfrei https://www.mdpi.com/1422-0067/24/8/7183 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 8, p 7183 |
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10.3390/ijms24087183 doi (DE-627)DOAJ089845498 (DE-599)DOAJa69b303fda604ae691e5b65ebcf52455 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Valeria Orrù verfasserin aut Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. extracellular vesicles flow cytometry GWAS Biology (General) Chemistry Francesca Virdis verfasserin aut Michele Marongiu verfasserin aut Valentina Serra verfasserin aut David Schlessinger verfasserin aut Marcella Devoto verfasserin aut Francesco Cucca verfasserin aut Edoardo Fiorillo verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 8, p 7183 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:8, p 7183 https://doi.org/10.3390/ijms24087183 kostenfrei https://doaj.org/article/a69b303fda604ae691e5b65ebcf52455 kostenfrei https://www.mdpi.com/1422-0067/24/8/7183 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 8, p 7183 |
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Valeria Orrù @@aut@@ Francesca Virdis @@aut@@ Michele Marongiu @@aut@@ Valentina Serra @@aut@@ David Schlessinger @@aut@@ Marcella Devoto @@aut@@ Francesco Cucca @@aut@@ Edoardo Fiorillo @@aut@@ |
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2023-01-01T00:00:00Z |
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DOAJ089845498 |
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englisch |
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Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets |
abstract |
Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. |
abstractGer |
Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. |
abstract_unstemmed |
Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. These findings suggest that EV formation is not a simple, constant adjunct of metabolism but is under both age-related and genetic control that can be independent of the regulation of the levels of the cells from which the EVs derive. |
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Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets |
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Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between sexes. GWAS revealed three statistically significant genetic signals associated with EV levels in the <i<F10</i< and <i<GBP1</i< genes and in the intergenic region between <i<LRIG1</i< and <i<KBTBD8</i<. These add to a signal in the 3′UTR of <i<RHOF</i< associated with CD31 expression on platelets that was previously found to be associated with other platelet traits. 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