Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine
Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Qixian Zhang [verfasserIn] Leo E. Gerweck [verfasserIn] Ethan Cascio [verfasserIn] Liqun Gu [verfasserIn] Qingyuan Yang [verfasserIn] Xinyue Dong [verfasserIn] Peigen Huang [verfasserIn] Alejandro Bertolet [verfasserIn] Konrad Pawel Nesteruk [verfasserIn] Wonmo Sung [verfasserIn] Aimee L. McNamara [verfasserIn] Jan Schuemann [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Cancers - MDPI AG, 2010, 15(2023), 8, p 2269 |
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| Übergeordnetes Werk: |
volume:15 ; year:2023 ; number:8, p 2269 |
| Links: |
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| DOI / URN: |
10.3390/cancers15082269 |
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| Katalog-ID: |
DOAJ089888545 |
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| 520 | |a Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. | ||
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10.3390/cancers15082269 doi (DE-627)DOAJ089888545 (DE-599)DOAJac9c787ada3c42079872bf598e94893d DE-627 ger DE-627 rakwb eng RC254-282 Qixian Zhang verfasserin aut Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. FLASH effect proton irradiation intestine lymphocyte depletion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leo E. Gerweck verfasserin aut Ethan Cascio verfasserin aut Liqun Gu verfasserin aut Qingyuan Yang verfasserin aut Xinyue Dong verfasserin aut Peigen Huang verfasserin aut Alejandro Bertolet verfasserin aut Konrad Pawel Nesteruk verfasserin aut Wonmo Sung verfasserin aut Aimee L. McNamara verfasserin aut Jan Schuemann verfasserin aut In Cancers MDPI AG, 2010 15(2023), 8, p 2269 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:8, p 2269 https://doi.org/10.3390/cancers15082269 kostenfrei https://doaj.org/article/ac9c787ada3c42079872bf598e94893d kostenfrei https://www.mdpi.com/2072-6694/15/8/2269 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 2269 |
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10.3390/cancers15082269 doi (DE-627)DOAJ089888545 (DE-599)DOAJac9c787ada3c42079872bf598e94893d DE-627 ger DE-627 rakwb eng RC254-282 Qixian Zhang verfasserin aut Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. FLASH effect proton irradiation intestine lymphocyte depletion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leo E. Gerweck verfasserin aut Ethan Cascio verfasserin aut Liqun Gu verfasserin aut Qingyuan Yang verfasserin aut Xinyue Dong verfasserin aut Peigen Huang verfasserin aut Alejandro Bertolet verfasserin aut Konrad Pawel Nesteruk verfasserin aut Wonmo Sung verfasserin aut Aimee L. McNamara verfasserin aut Jan Schuemann verfasserin aut In Cancers MDPI AG, 2010 15(2023), 8, p 2269 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:8, p 2269 https://doi.org/10.3390/cancers15082269 kostenfrei https://doaj.org/article/ac9c787ada3c42079872bf598e94893d kostenfrei https://www.mdpi.com/2072-6694/15/8/2269 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 2269 |
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10.3390/cancers15082269 doi (DE-627)DOAJ089888545 (DE-599)DOAJac9c787ada3c42079872bf598e94893d DE-627 ger DE-627 rakwb eng RC254-282 Qixian Zhang verfasserin aut Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. FLASH effect proton irradiation intestine lymphocyte depletion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leo E. Gerweck verfasserin aut Ethan Cascio verfasserin aut Liqun Gu verfasserin aut Qingyuan Yang verfasserin aut Xinyue Dong verfasserin aut Peigen Huang verfasserin aut Alejandro Bertolet verfasserin aut Konrad Pawel Nesteruk verfasserin aut Wonmo Sung verfasserin aut Aimee L. McNamara verfasserin aut Jan Schuemann verfasserin aut In Cancers MDPI AG, 2010 15(2023), 8, p 2269 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:8, p 2269 https://doi.org/10.3390/cancers15082269 kostenfrei https://doaj.org/article/ac9c787ada3c42079872bf598e94893d kostenfrei https://www.mdpi.com/2072-6694/15/8/2269 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 2269 |
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10.3390/cancers15082269 doi (DE-627)DOAJ089888545 (DE-599)DOAJac9c787ada3c42079872bf598e94893d DE-627 ger DE-627 rakwb eng RC254-282 Qixian Zhang verfasserin aut Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. FLASH effect proton irradiation intestine lymphocyte depletion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leo E. Gerweck verfasserin aut Ethan Cascio verfasserin aut Liqun Gu verfasserin aut Qingyuan Yang verfasserin aut Xinyue Dong verfasserin aut Peigen Huang verfasserin aut Alejandro Bertolet verfasserin aut Konrad Pawel Nesteruk verfasserin aut Wonmo Sung verfasserin aut Aimee L. McNamara verfasserin aut Jan Schuemann verfasserin aut In Cancers MDPI AG, 2010 15(2023), 8, p 2269 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:8, p 2269 https://doi.org/10.3390/cancers15082269 kostenfrei https://doaj.org/article/ac9c787ada3c42079872bf598e94893d kostenfrei https://www.mdpi.com/2072-6694/15/8/2269 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 2269 |
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10.3390/cancers15082269 doi (DE-627)DOAJ089888545 (DE-599)DOAJac9c787ada3c42079872bf598e94893d DE-627 ger DE-627 rakwb eng RC254-282 Qixian Zhang verfasserin aut Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. FLASH effect proton irradiation intestine lymphocyte depletion Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leo E. Gerweck verfasserin aut Ethan Cascio verfasserin aut Liqun Gu verfasserin aut Qingyuan Yang verfasserin aut Xinyue Dong verfasserin aut Peigen Huang verfasserin aut Alejandro Bertolet verfasserin aut Konrad Pawel Nesteruk verfasserin aut Wonmo Sung verfasserin aut Aimee L. McNamara verfasserin aut Jan Schuemann verfasserin aut In Cancers MDPI AG, 2010 15(2023), 8, p 2269 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:8, p 2269 https://doi.org/10.3390/cancers15082269 kostenfrei https://doaj.org/article/ac9c787ada3c42079872bf598e94893d kostenfrei https://www.mdpi.com/2072-6694/15/8/2269 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 2269 |
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Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine |
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Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. |
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Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. |
| abstract_unstemmed |
Ultra-high dose rate irradiation has been reported to protect normal tissues more than conventional dose rate irradiation. This tissue sparing has been termed the FLASH effect. We investigated the FLASH effect of proton irradiation on the intestine as well as the hypothesis that lymphocyte depletion is a cause of the FLASH effect. A 16 × 12 mm<sup<2</sup< elliptical field with a dose rate of ~120 Gy/s was provided by a 228 MeV proton pencil beam. Partial abdominal irradiation was delivered to C57BL/6j and immunodeficient Rag1<sup<−/−</sup</C57 mice. Proliferating crypt cells were counted at 2 days post exposure, and the thickness of the muscularis externa was measured at 280 days following irradiation. FLASH irradiation did not reduce the morbidity or mortality of conventional irradiation in either strain of mice; in fact, a tendency for worse survival in FLASH-irradiated mice was observed. There were no significant differences in lymphocyte numbers between FLASH and conventional-dose-rate mice. A similar number of proliferating crypt cells and a similar thickness of the muscularis externa following FLASH and conventional dose rate irradiation were observed. Partial abdominal FLASH proton irradiation at 120 Gy/s did not spare normal intestinal tissue, and no difference in lymphocyte depletion was observed. This study suggests that the effect of FLASH irradiation may depend on multiple factors, and in some cases dose rates of over 100 Gy/s do not induce a FLASH effect and can even result in worse outcomes. |
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Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine |
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https://doi.org/10.3390/cancers15082269 https://doaj.org/article/ac9c787ada3c42079872bf598e94893d https://www.mdpi.com/2072-6694/15/8/2269 https://doaj.org/toc/2072-6694 |
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Leo E. Gerweck Ethan Cascio Liqun Gu Qingyuan Yang Xinyue Dong Peigen Huang Alejandro Bertolet Konrad Pawel Nesteruk Wonmo Sung Aimee L. McNamara Jan Schuemann |
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Leo E. Gerweck Ethan Cascio Liqun Gu Qingyuan Yang Xinyue Dong Peigen Huang Alejandro Bertolet Konrad Pawel Nesteruk Wonmo Sung Aimee L. McNamara Jan Schuemann |
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2024-07-04T01:04:19.449Z |
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