The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer

The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary mo...
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Gespeichert in:

Autor*in:	Ying Pang [verfasserIn] Xu Chen [verfasserIn] Tongjie Ji [verfasserIn] Meng Cheng [verfasserIn] Rui Wang [verfasserIn] Chunyu Zhang [verfasserIn] Min Liu [verfasserIn] Jing Zhang [verfasserIn] Chunlong Zhong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) death-domain-associated protein (DAXX) DNA damage replication stress tumorigenesis

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 8, p 2228
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:8, p 2228

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15082228

Katalog-ID:	DOAJ089888952

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520			\|a The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary molecular characteristics of ATRX, including its molecular structures and normal and malignant biological roles, are reviewed in this article. We discuss the role of ATRX in its interactions with the histone variant H3.3, chromatin remodeling, DNA damage response, replication stress, and cancers, particularly gliomas, neuroblastomas, and pancreatic neuroendocrine tumors. ATRX is implicated in several important cellular processes and serves a crucial function in regulating gene expression and genomic integrity throughout embryogenesis. However, the nature of its involvement in the growth and development of cancer remains unknown. As mechanistic and molecular investigations on ATRX disclose its essential functions in cancer, customized therapies targeting ATRX will become accessible.
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allfieldsSound	10.3390/cancers15082228 doi (DE-627)DOAJ089888952 (DE-599)DOAJf814ec908e284ee68c39a0865d857d14 DE-627 ger DE-627 rakwb eng RC254-282 Ying Pang verfasserin aut The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary molecular characteristics of ATRX, including its molecular structures and normal and malignant biological roles, are reviewed in this article. We discuss the role of ATRX in its interactions with the histone variant H3.3, chromatin remodeling, DNA damage response, replication stress, and cancers, particularly gliomas, neuroblastomas, and pancreatic neuroendocrine tumors. ATRX is implicated in several important cellular processes and serves a crucial function in regulating gene expression and genomic integrity throughout embryogenesis. However, the nature of its involvement in the growth and development of cancer remains unknown. As mechanistic and molecular investigations on ATRX disclose its essential functions in cancer, customized therapies targeting ATRX will become accessible. alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) death-domain-associated protein (DAXX) DNA damage replication stress tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xu Chen verfasserin aut Tongjie Ji verfasserin aut Meng Cheng verfasserin aut Rui Wang verfasserin aut Chunyu Zhang verfasserin aut Min Liu verfasserin aut Jing Zhang verfasserin aut Chunlong Zhong verfasserin aut In Cancers MDPI AG, 2010 15(2023), 8, p 2228 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:8, p 2228 https://doi.org/10.3390/cancers15082228 kostenfrei https://doaj.org/article/f814ec908e284ee68c39a0865d857d14 kostenfrei https://www.mdpi.com/2072-6694/15/8/2228 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 8, p 2228
language	English
source	In Cancers 15(2023), 8, p 2228 volume:15 year:2023 number:8, p 2228
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topic_facet	alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) death-domain-associated protein (DAXX) DNA damage replication stress tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Cancers
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callnumber-first	R - Medicine
author	Ying Pang
spellingShingle	Ying Pang misc RC254-282 misc alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) misc death-domain-associated protein (DAXX) misc DNA damage misc replication stress misc tumorigenesis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer
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topic_title	RC254-282 The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) death-domain-associated protein (DAXX) DNA damage replication stress tumorigenesis
topic	misc RC254-282 misc alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) misc death-domain-associated protein (DAXX) misc DNA damage misc replication stress misc tumorigenesis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) misc death-domain-associated protein (DAXX) misc DNA damage misc replication stress misc tumorigenesis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc alpha-thalassemia mental retardation X-linked syndrome protein (ATRX) misc death-domain-associated protein (DAXX) misc DNA damage misc replication stress misc tumorigenesis misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer
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title_full	The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer
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title_sort	chromatin remodeler atrx: role and mechanism in biology and cancer
callnumber	RC254-282
title_auth	The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer
abstract	The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary molecular characteristics of ATRX, including its molecular structures and normal and malignant biological roles, are reviewed in this article. We discuss the role of ATRX in its interactions with the histone variant H3.3, chromatin remodeling, DNA damage response, replication stress, and cancers, particularly gliomas, neuroblastomas, and pancreatic neuroendocrine tumors. ATRX is implicated in several important cellular processes and serves a crucial function in regulating gene expression and genomic integrity throughout embryogenesis. However, the nature of its involvement in the growth and development of cancer remains unknown. As mechanistic and molecular investigations on ATRX disclose its essential functions in cancer, customized therapies targeting ATRX will become accessible.
abstractGer	The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary molecular characteristics of ATRX, including its molecular structures and normal and malignant biological roles, are reviewed in this article. We discuss the role of ATRX in its interactions with the histone variant H3.3, chromatin remodeling, DNA damage response, replication stress, and cancers, particularly gliomas, neuroblastomas, and pancreatic neuroendocrine tumors. ATRX is implicated in several important cellular processes and serves a crucial function in regulating gene expression and genomic integrity throughout embryogenesis. However, the nature of its involvement in the growth and development of cancer remains unknown. As mechanistic and molecular investigations on ATRX disclose its essential functions in cancer, customized therapies targeting ATRX will become accessible.
abstract_unstemmed	The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary molecular characteristics of ATRX, including its molecular structures and normal and malignant biological roles, are reviewed in this article. We discuss the role of ATRX in its interactions with the histone variant H3.3, chromatin remodeling, DNA damage response, replication stress, and cancers, particularly gliomas, neuroblastomas, and pancreatic neuroendocrine tumors. ATRX is implicated in several important cellular processes and serves a crucial function in regulating gene expression and genomic integrity throughout embryogenesis. However, the nature of its involvement in the growth and development of cancer remains unknown. As mechanistic and molecular investigations on ATRX disclose its essential functions in cancer, customized therapies targeting ATRX will become accessible.
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title_short	The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer
url	https://doi.org/10.3390/cancers15082228 https://doaj.org/article/f814ec908e284ee68c39a0865d857d14 https://www.mdpi.com/2072-6694/15/8/2228 https://doaj.org/toc/2072-6694
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