Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis

<i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performance...
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Autor*in:	Pasquale Paribello [verfasserIn] Alessio Squassina [verfasserIn] Claudia Pisanu [verfasserIn] Anna Meloni [verfasserIn] Stefano Dall’Acqua [verfasserIn] Stefania Sut [verfasserIn] Sofia Nasini [verfasserIn] Antonella Bertazzo [verfasserIn] Donatella Congiu [verfasserIn] Mario Garzilli [verfasserIn] Beatrice Guiso [verfasserIn] Federico Suprani [verfasserIn] Vittoria Pulcinelli [verfasserIn] Maria Novella Iaselli [verfasserIn] Ilaria Pinna [verfasserIn] Giulia Somaini [verfasserIn] Laura Arru [verfasserIn] Carolina Corrias [verfasserIn] Federica Pinna [verfasserIn] Bernardo Carpiniello [verfasserIn] Stefano Comai [verfasserIn] Mirko Manchia [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	hot cognition affective recognition suicide lifetime attempts tryptophan metabolism

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 13(2023), 4, p 693
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:4, p 693

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci13040693

Katalog-ID:	DOAJ089892453

Internformat


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520			\|a <i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association.
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allfields	10.3390/brainsci13040693 doi (DE-627)DOAJ089892453 (DE-599)DOAJ2a9577058629418a92190c06341799c5 DE-627 ger DE-627 rakwb eng RC321-571 Pasquale Paribello verfasserin aut Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association. hot cognition affective recognition suicide lifetime attempts tryptophan metabolism Neurosciences. Biological psychiatry. Neuropsychiatry Alessio Squassina verfasserin aut Claudia Pisanu verfasserin aut Anna Meloni verfasserin aut Stefano Dall’Acqua verfasserin aut Stefania Sut verfasserin aut Sofia Nasini verfasserin aut Antonella Bertazzo verfasserin aut Donatella Congiu verfasserin aut Mario Garzilli verfasserin aut Beatrice Guiso verfasserin aut Federico Suprani verfasserin aut Vittoria Pulcinelli verfasserin aut Maria Novella Iaselli verfasserin aut Ilaria Pinna verfasserin aut Giulia Somaini verfasserin aut Laura Arru verfasserin aut Carolina Corrias verfasserin aut Federica Pinna verfasserin aut Bernardo Carpiniello verfasserin aut Stefano Comai verfasserin aut Mirko Manchia verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 4, p 693 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:4, p 693 https://doi.org/10.3390/brainsci13040693 kostenfrei https://doaj.org/article/2a9577058629418a92190c06341799c5 kostenfrei https://www.mdpi.com/2076-3425/13/4/693 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4, p 693
spelling	10.3390/brainsci13040693 doi (DE-627)DOAJ089892453 (DE-599)DOAJ2a9577058629418a92190c06341799c5 DE-627 ger DE-627 rakwb eng RC321-571 Pasquale Paribello verfasserin aut Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association. hot cognition affective recognition suicide lifetime attempts tryptophan metabolism Neurosciences. Biological psychiatry. Neuropsychiatry Alessio Squassina verfasserin aut Claudia Pisanu verfasserin aut Anna Meloni verfasserin aut Stefano Dall’Acqua verfasserin aut Stefania Sut verfasserin aut Sofia Nasini verfasserin aut Antonella Bertazzo verfasserin aut Donatella Congiu verfasserin aut Mario Garzilli verfasserin aut Beatrice Guiso verfasserin aut Federico Suprani verfasserin aut Vittoria Pulcinelli verfasserin aut Maria Novella Iaselli verfasserin aut Ilaria Pinna verfasserin aut Giulia Somaini verfasserin aut Laura Arru verfasserin aut Carolina Corrias verfasserin aut Federica Pinna verfasserin aut Bernardo Carpiniello verfasserin aut Stefano Comai verfasserin aut Mirko Manchia verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 4, p 693 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:4, p 693 https://doi.org/10.3390/brainsci13040693 kostenfrei https://doaj.org/article/2a9577058629418a92190c06341799c5 kostenfrei https://www.mdpi.com/2076-3425/13/4/693 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4, p 693
allfields_unstemmed	10.3390/brainsci13040693 doi (DE-627)DOAJ089892453 (DE-599)DOAJ2a9577058629418a92190c06341799c5 DE-627 ger DE-627 rakwb eng RC321-571 Pasquale Paribello verfasserin aut Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association. hot cognition affective recognition suicide lifetime attempts tryptophan metabolism Neurosciences. Biological psychiatry. Neuropsychiatry Alessio Squassina verfasserin aut Claudia Pisanu verfasserin aut Anna Meloni verfasserin aut Stefano Dall’Acqua verfasserin aut Stefania Sut verfasserin aut Sofia Nasini verfasserin aut Antonella Bertazzo verfasserin aut Donatella Congiu verfasserin aut Mario Garzilli verfasserin aut Beatrice Guiso verfasserin aut Federico Suprani verfasserin aut Vittoria Pulcinelli verfasserin aut Maria Novella Iaselli verfasserin aut Ilaria Pinna verfasserin aut Giulia Somaini verfasserin aut Laura Arru verfasserin aut Carolina Corrias verfasserin aut Federica Pinna verfasserin aut Bernardo Carpiniello verfasserin aut Stefano Comai verfasserin aut Mirko Manchia verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 4, p 693 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:4, p 693 https://doi.org/10.3390/brainsci13040693 kostenfrei https://doaj.org/article/2a9577058629418a92190c06341799c5 kostenfrei https://www.mdpi.com/2076-3425/13/4/693 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4, p 693
allfieldsGer	10.3390/brainsci13040693 doi (DE-627)DOAJ089892453 (DE-599)DOAJ2a9577058629418a92190c06341799c5 DE-627 ger DE-627 rakwb eng RC321-571 Pasquale Paribello verfasserin aut Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association. hot cognition affective recognition suicide lifetime attempts tryptophan metabolism Neurosciences. Biological psychiatry. Neuropsychiatry Alessio Squassina verfasserin aut Claudia Pisanu verfasserin aut Anna Meloni verfasserin aut Stefano Dall’Acqua verfasserin aut Stefania Sut verfasserin aut Sofia Nasini verfasserin aut Antonella Bertazzo verfasserin aut Donatella Congiu verfasserin aut Mario Garzilli verfasserin aut Beatrice Guiso verfasserin aut Federico Suprani verfasserin aut Vittoria Pulcinelli verfasserin aut Maria Novella Iaselli verfasserin aut Ilaria Pinna verfasserin aut Giulia Somaini verfasserin aut Laura Arru verfasserin aut Carolina Corrias verfasserin aut Federica Pinna verfasserin aut Bernardo Carpiniello verfasserin aut Stefano Comai verfasserin aut Mirko Manchia verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 4, p 693 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:4, p 693 https://doi.org/10.3390/brainsci13040693 kostenfrei https://doaj.org/article/2a9577058629418a92190c06341799c5 kostenfrei https://www.mdpi.com/2076-3425/13/4/693 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4, p 693
allfieldsSound	10.3390/brainsci13040693 doi (DE-627)DOAJ089892453 (DE-599)DOAJ2a9577058629418a92190c06341799c5 DE-627 ger DE-627 rakwb eng RC321-571 Pasquale Paribello verfasserin aut Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association. hot cognition affective recognition suicide lifetime attempts tryptophan metabolism Neurosciences. Biological psychiatry. Neuropsychiatry Alessio Squassina verfasserin aut Claudia Pisanu verfasserin aut Anna Meloni verfasserin aut Stefano Dall’Acqua verfasserin aut Stefania Sut verfasserin aut Sofia Nasini verfasserin aut Antonella Bertazzo verfasserin aut Donatella Congiu verfasserin aut Mario Garzilli verfasserin aut Beatrice Guiso verfasserin aut Federico Suprani verfasserin aut Vittoria Pulcinelli verfasserin aut Maria Novella Iaselli verfasserin aut Ilaria Pinna verfasserin aut Giulia Somaini verfasserin aut Laura Arru verfasserin aut Carolina Corrias verfasserin aut Federica Pinna verfasserin aut Bernardo Carpiniello verfasserin aut Stefano Comai verfasserin aut Mirko Manchia verfasserin aut In Brain Sciences MDPI AG, 2012 13(2023), 4, p 693 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:13 year:2023 number:4, p 693 https://doi.org/10.3390/brainsci13040693 kostenfrei https://doaj.org/article/2a9577058629418a92190c06341799c5 kostenfrei https://www.mdpi.com/2076-3425/13/4/693 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4, p 693
language	English
source	In Brain Sciences 13(2023), 4, p 693 volume:13 year:2023 number:4, p 693
sourceStr	In Brain Sciences 13(2023), 4, p 693 volume:13 year:2023 number:4, p 693
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hot cognition affective recognition suicide lifetime attempts tryptophan metabolism Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Brain Sciences
authorswithroles_txt_mv	Pasquale Paribello @@aut@@ Alessio Squassina @@aut@@ Claudia Pisanu @@aut@@ Anna Meloni @@aut@@ Stefano Dall’Acqua @@aut@@ Stefania Sut @@aut@@ Sofia Nasini @@aut@@ Antonella Bertazzo @@aut@@ Donatella Congiu @@aut@@ Mario Garzilli @@aut@@ Beatrice Guiso @@aut@@ Federico Suprani @@aut@@ Vittoria Pulcinelli @@aut@@ Maria Novella Iaselli @@aut@@ Ilaria Pinna @@aut@@ Giulia Somaini @@aut@@ Laura Arru @@aut@@ Carolina Corrias @@aut@@ Federica Pinna @@aut@@ Bernardo Carpiniello @@aut@@ Stefano Comai @@aut@@ Mirko Manchia @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	687718139
id	DOAJ089892453
language_de	englisch
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callnumber-first	R - Medicine
author	Pasquale Paribello
spellingShingle	Pasquale Paribello misc RC321-571 misc hot cognition misc affective recognition misc suicide lifetime attempts misc tryptophan metabolism misc Neurosciences. Biological psychiatry. Neuropsychiatry Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis
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topic_title	RC321-571 Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis hot cognition affective recognition suicide lifetime attempts tryptophan metabolism
topic	misc RC321-571 misc hot cognition misc affective recognition misc suicide lifetime attempts misc tryptophan metabolism misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc hot cognition misc affective recognition misc suicide lifetime attempts misc tryptophan metabolism misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis
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title_full	Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis
author_sort	Pasquale Paribello
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author_browse	Pasquale Paribello Alessio Squassina Claudia Pisanu Anna Meloni Stefano Dall’Acqua Stefania Sut Sofia Nasini Antonella Bertazzo Donatella Congiu Mario Garzilli Beatrice Guiso Federico Suprani Vittoria Pulcinelli Maria Novella Iaselli Ilaria Pinna Giulia Somaini Laura Arru Carolina Corrias Federica Pinna Bernardo Carpiniello Stefano Comai Mirko Manchia
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title_sort	probing the association between cognition, suicidal behavior and tryptophan metabolism in a sample of individuals living with bipolar disorder: a secondary analysis
callnumber	RC321-571
title_auth	Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis
abstract	<i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association.
abstractGer	<i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association.
abstract_unstemmed	<i<Background and Objectives</i<: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <i<Materials and Methods</i<: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <i<Results</i<: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <i<Conclusions</i<: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association.
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title_short	Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis
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