Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy

Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we prop...
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Autor*in:	Biao Quan [verfasserIn] Xiangdong Liu [verfasserIn] Shuang Zhao [verfasserIn] Xiang Chen [verfasserIn] Xuan Zhang [verfasserIn] Zeyu Chen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy

Übergeordnetes Werk:	In: Bioengineering - MDPI AG, 2014, 10(2023), 4, p 428
Übergeordnetes Werk:	volume:10 ; year:2023 ; number:4, p 428

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/bioengineering10040428

Katalog-ID:	DOAJ089901037

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520			\|a Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients.
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allfields	10.3390/bioengineering10040428 doi (DE-627)DOAJ089901037 (DE-599)DOAJ4b5788880628468ba56865dd90a7843a DE-627 ger DE-627 rakwb eng QH301-705.5 Biao Quan verfasserin aut Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients. deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy Technology T Biology (General) Xiangdong Liu verfasserin aut Shuang Zhao verfasserin aut Xiang Chen verfasserin aut Xuan Zhang verfasserin aut Zeyu Chen verfasserin aut In Bioengineering MDPI AG, 2014 10(2023), 4, p 428 (DE-627)774814020 (DE-600)2746191-9 23065354 nnns volume:10 year:2023 number:4, p 428 https://doi.org/10.3390/bioengineering10040428 kostenfrei https://doaj.org/article/4b5788880628468ba56865dd90a7843a kostenfrei https://www.mdpi.com/2306-5354/10/4/428 kostenfrei https://doaj.org/toc/2306-5354 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 4, p 428
spelling	10.3390/bioengineering10040428 doi (DE-627)DOAJ089901037 (DE-599)DOAJ4b5788880628468ba56865dd90a7843a DE-627 ger DE-627 rakwb eng QH301-705.5 Biao Quan verfasserin aut Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients. deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy Technology T Biology (General) Xiangdong Liu verfasserin aut Shuang Zhao verfasserin aut Xiang Chen verfasserin aut Xuan Zhang verfasserin aut Zeyu Chen verfasserin aut In Bioengineering MDPI AG, 2014 10(2023), 4, p 428 (DE-627)774814020 (DE-600)2746191-9 23065354 nnns volume:10 year:2023 number:4, p 428 https://doi.org/10.3390/bioengineering10040428 kostenfrei https://doaj.org/article/4b5788880628468ba56865dd90a7843a kostenfrei https://www.mdpi.com/2306-5354/10/4/428 kostenfrei https://doaj.org/toc/2306-5354 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 4, p 428
allfields_unstemmed	10.3390/bioengineering10040428 doi (DE-627)DOAJ089901037 (DE-599)DOAJ4b5788880628468ba56865dd90a7843a DE-627 ger DE-627 rakwb eng QH301-705.5 Biao Quan verfasserin aut Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients. deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy Technology T Biology (General) Xiangdong Liu verfasserin aut Shuang Zhao verfasserin aut Xiang Chen verfasserin aut Xuan Zhang verfasserin aut Zeyu Chen verfasserin aut In Bioengineering MDPI AG, 2014 10(2023), 4, p 428 (DE-627)774814020 (DE-600)2746191-9 23065354 nnns volume:10 year:2023 number:4, p 428 https://doi.org/10.3390/bioengineering10040428 kostenfrei https://doaj.org/article/4b5788880628468ba56865dd90a7843a kostenfrei https://www.mdpi.com/2306-5354/10/4/428 kostenfrei https://doaj.org/toc/2306-5354 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 4, p 428
allfieldsGer	10.3390/bioengineering10040428 doi (DE-627)DOAJ089901037 (DE-599)DOAJ4b5788880628468ba56865dd90a7843a DE-627 ger DE-627 rakwb eng QH301-705.5 Biao Quan verfasserin aut Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients. deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy Technology T Biology (General) Xiangdong Liu verfasserin aut Shuang Zhao verfasserin aut Xiang Chen verfasserin aut Xuan Zhang verfasserin aut Zeyu Chen verfasserin aut In Bioengineering MDPI AG, 2014 10(2023), 4, p 428 (DE-627)774814020 (DE-600)2746191-9 23065354 nnns volume:10 year:2023 number:4, p 428 https://doi.org/10.3390/bioengineering10040428 kostenfrei https://doaj.org/article/4b5788880628468ba56865dd90a7843a kostenfrei https://www.mdpi.com/2306-5354/10/4/428 kostenfrei https://doaj.org/toc/2306-5354 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 4, p 428
allfieldsSound	10.3390/bioengineering10040428 doi (DE-627)DOAJ089901037 (DE-599)DOAJ4b5788880628468ba56865dd90a7843a DE-627 ger DE-627 rakwb eng QH301-705.5 Biao Quan verfasserin aut Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients. deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy Technology T Biology (General) Xiangdong Liu verfasserin aut Shuang Zhao verfasserin aut Xiang Chen verfasserin aut Xuan Zhang verfasserin aut Zeyu Chen verfasserin aut In Bioengineering MDPI AG, 2014 10(2023), 4, p 428 (DE-627)774814020 (DE-600)2746191-9 23065354 nnns volume:10 year:2023 number:4, p 428 https://doi.org/10.3390/bioengineering10040428 kostenfrei https://doaj.org/article/4b5788880628468ba56865dd90a7843a kostenfrei https://www.mdpi.com/2306-5354/10/4/428 kostenfrei https://doaj.org/toc/2306-5354 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2023 4, p 428
language	English
source	In Bioengineering 10(2023), 4, p 428 volume:10 year:2023 number:4, p 428
sourceStr	In Bioengineering 10(2023), 4, p 428 volume:10 year:2023 number:4, p 428
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topic_facet	deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy Technology T Biology (General)
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container_title	Bioengineering
authorswithroles_txt_mv	Biao Quan @@aut@@ Xiangdong Liu @@aut@@ Shuang Zhao @@aut@@ Xiang Chen @@aut@@ Xuan Zhang @@aut@@ Zeyu Chen @@aut@@
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callnumber-first	Q - Science
author	Biao Quan
spellingShingle	Biao Quan misc QH301-705.5 misc deconvolution misc early detection misc ocular choroidal melanoma misc three-frame difference misc ultrasound localization microscopy misc Technology misc T misc Biology (General) Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy
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topic_title	QH301-705.5 Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy deconvolution early detection ocular choroidal melanoma three-frame difference ultrasound localization microscopy
topic	misc QH301-705.5 misc deconvolution misc early detection misc ocular choroidal melanoma misc three-frame difference misc ultrasound localization microscopy misc Technology misc T misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc deconvolution misc early detection misc ocular choroidal melanoma misc three-frame difference misc ultrasound localization microscopy misc Technology misc T misc Biology (General)
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title	Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy
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title_full	Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy
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title_sort	detecting early ocular choroidal melanoma using ultrasound localization microscopy
callnumber	QH301-705.5
title_auth	Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy
abstract	Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients.
abstractGer	Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients.
abstract_unstemmed	Ocular choroidal melanoma (OCM) is the most common ocular primary malignant tumor in adults, and there is an increasing emphasis on its early detection and treatment worldwide. The main obstacle in early detection of OCM is its overlapping clinical features with benign choroidal nevus. Thus, we propose ultrasound localization microscopy (ULM) based on the image deconvolution algorithm to assist the diagnosis of small OCM in early stages. Furthermore, we develop ultrasound (US) plane wave imaging based on three-frame difference algorithm to guide the placement of the probe on the field of view. A high-frequency Verasonics Vantage system and an L22-14v linear array transducer were used to perform experiments on both custom-made modules in vitro and a SD rat with ocular choroidal melanoma in vivo. The results demonstrate that our proposed deconvolution method implement more robust microbubble (MB) localization, reconstruction of microvasculature network in a finer grid and more precise flow velocity estimation. The excellent performance of US plane wave imaging was successfully validated on the flow phantom and in an in vivo OCM model. In the future, the super-resolution ULM, a critical complementary imaging modality, can provide doctors with conclusive suggestions for early diagnosis of OCM, which is significant for the treatment and prognosis of patients.
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title_short	Detecting Early Ocular Choroidal Melanoma Using Ultrasound Localization Microscopy
url	https://doi.org/10.3390/bioengineering10040428 https://doaj.org/article/4b5788880628468ba56865dd90a7843a https://www.mdpi.com/2306-5354/10/4/428 https://doaj.org/toc/2306-5354
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author2	Xiangdong Liu Shuang Zhao Xiang Chen Xuan Zhang Zeyu Chen
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