Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds

Crop domestication has resulted in nutrient losses, so evaluating the reshaping of phytonutrients is crucial for improving nutrition. Soybean is an ideal model due to its abundant phytonutrients and wild relatives. In order to unravel the domestication consequence of phytonutrients, comparative and...
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Autor*in:	Xuetong Li [verfasserIn] Sujuan Li [verfasserIn] Jian Wang [verfasserIn] Guang Chen [verfasserIn] Xiaoyuan Tao [verfasserIn] Shengchun Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	wild soybeans untargeted metabolomics domestication-driven reshaping polyphenolic antioxidants acylation

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 12(2023), 4, p 912
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:4, p 912

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox12040912

Katalog-ID:	DOAJ089912551

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520			\|a Crop domestication has resulted in nutrient losses, so evaluating the reshaping of phytonutrients is crucial for improving nutrition. Soybean is an ideal model due to its abundant phytonutrients and wild relatives. In order to unravel the domestication consequence of phytonutrients, comparative and association analyses of metabolomes and antioxidant activities were performed on seeds of six wild (<i<Glycine soja</i< (Sieb. and Zucc.)) and six cultivated soybeans (<i<Glycine max</i< (L.) Merr.). Through ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS), we observed a greater metabolic diversity in wild soybeans, which also displayed higher antioxidant activities. (−)-Epicatechin, a potent antioxidant, displayed a 1750-fold greater abundance in wild soybeans than in cultivated soybeans. Multiple polyphenols in the catechin biosynthesis pathway were significantly higher in wild soybeans, including phlorizin, taxifolin, quercetin 3-<i<O</i<-galactoside, cyanidin 3-<i<O</i<-glucoside, (+)-catechin, (−)-epiafzelechin, catechin–glucoside, and three proanthocyanidins. They showed significant positive correlations with each other and antioxidant activities, indicating their cooperative contribution to the high antioxidant activities of wild soybeans. Additionally, natural acylation related to functional properties was characterized in a diverse range of polyphenols. Our study reveals the comprehensive reprogramming of polyphenolic antioxidants during domestication, providing valuable insights for metabolism-assisted fortification of crop nutrition.
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source	In Antioxidants 12(2023), 4, p 912 volume:12 year:2023 number:4, p 912
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authorswithroles_txt_mv	Xuetong Li @@aut@@ Sujuan Li @@aut@@ Jian Wang @@aut@@ Guang Chen @@aut@@ Xiaoyuan Tao @@aut@@ Shengchun Xu @@aut@@
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callnumber-first	R - Medicine
author	Xuetong Li
spellingShingle	Xuetong Li misc RM1-950 misc wild soybeans misc untargeted metabolomics misc domestication-driven reshaping misc polyphenolic antioxidants misc acylation misc Therapeutics. Pharmacology Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds
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topic_title	RM1-950 Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds wild soybeans untargeted metabolomics domestication-driven reshaping polyphenolic antioxidants acylation
topic	misc RM1-950 misc wild soybeans misc untargeted metabolomics misc domestication-driven reshaping misc polyphenolic antioxidants misc acylation misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc wild soybeans misc untargeted metabolomics misc domestication-driven reshaping misc polyphenolic antioxidants misc acylation misc Therapeutics. Pharmacology
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title	Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds
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title_full	Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds
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author_browse	Xuetong Li Sujuan Li Jian Wang Guang Chen Xiaoyuan Tao Shengchun Xu
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title_sort	metabolomic analysis reveals domestication-driven reshaping of polyphenolic antioxidants in soybean seeds
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title_auth	Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds
abstract	Crop domestication has resulted in nutrient losses, so evaluating the reshaping of phytonutrients is crucial for improving nutrition. Soybean is an ideal model due to its abundant phytonutrients and wild relatives. In order to unravel the domestication consequence of phytonutrients, comparative and association analyses of metabolomes and antioxidant activities were performed on seeds of six wild (<i<Glycine soja</i< (Sieb. and Zucc.)) and six cultivated soybeans (<i<Glycine max</i< (L.) Merr.). Through ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS), we observed a greater metabolic diversity in wild soybeans, which also displayed higher antioxidant activities. (−)-Epicatechin, a potent antioxidant, displayed a 1750-fold greater abundance in wild soybeans than in cultivated soybeans. Multiple polyphenols in the catechin biosynthesis pathway were significantly higher in wild soybeans, including phlorizin, taxifolin, quercetin 3-<i<O</i<-galactoside, cyanidin 3-<i<O</i<-glucoside, (+)-catechin, (−)-epiafzelechin, catechin–glucoside, and three proanthocyanidins. They showed significant positive correlations with each other and antioxidant activities, indicating their cooperative contribution to the high antioxidant activities of wild soybeans. Additionally, natural acylation related to functional properties was characterized in a diverse range of polyphenols. Our study reveals the comprehensive reprogramming of polyphenolic antioxidants during domestication, providing valuable insights for metabolism-assisted fortification of crop nutrition.
abstractGer	Crop domestication has resulted in nutrient losses, so evaluating the reshaping of phytonutrients is crucial for improving nutrition. Soybean is an ideal model due to its abundant phytonutrients and wild relatives. In order to unravel the domestication consequence of phytonutrients, comparative and association analyses of metabolomes and antioxidant activities were performed on seeds of six wild (<i<Glycine soja</i< (Sieb. and Zucc.)) and six cultivated soybeans (<i<Glycine max</i< (L.) Merr.). Through ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS), we observed a greater metabolic diversity in wild soybeans, which also displayed higher antioxidant activities. (−)-Epicatechin, a potent antioxidant, displayed a 1750-fold greater abundance in wild soybeans than in cultivated soybeans. Multiple polyphenols in the catechin biosynthesis pathway were significantly higher in wild soybeans, including phlorizin, taxifolin, quercetin 3-<i<O</i<-galactoside, cyanidin 3-<i<O</i<-glucoside, (+)-catechin, (−)-epiafzelechin, catechin–glucoside, and three proanthocyanidins. They showed significant positive correlations with each other and antioxidant activities, indicating their cooperative contribution to the high antioxidant activities of wild soybeans. Additionally, natural acylation related to functional properties was characterized in a diverse range of polyphenols. Our study reveals the comprehensive reprogramming of polyphenolic antioxidants during domestication, providing valuable insights for metabolism-assisted fortification of crop nutrition.
abstract_unstemmed	Crop domestication has resulted in nutrient losses, so evaluating the reshaping of phytonutrients is crucial for improving nutrition. Soybean is an ideal model due to its abundant phytonutrients and wild relatives. In order to unravel the domestication consequence of phytonutrients, comparative and association analyses of metabolomes and antioxidant activities were performed on seeds of six wild (<i<Glycine soja</i< (Sieb. and Zucc.)) and six cultivated soybeans (<i<Glycine max</i< (L.) Merr.). Through ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS), we observed a greater metabolic diversity in wild soybeans, which also displayed higher antioxidant activities. (−)-Epicatechin, a potent antioxidant, displayed a 1750-fold greater abundance in wild soybeans than in cultivated soybeans. Multiple polyphenols in the catechin biosynthesis pathway were significantly higher in wild soybeans, including phlorizin, taxifolin, quercetin 3-<i<O</i<-galactoside, cyanidin 3-<i<O</i<-glucoside, (+)-catechin, (−)-epiafzelechin, catechin–glucoside, and three proanthocyanidins. They showed significant positive correlations with each other and antioxidant activities, indicating their cooperative contribution to the high antioxidant activities of wild soybeans. Additionally, natural acylation related to functional properties was characterized in a diverse range of polyphenols. Our study reveals the comprehensive reprogramming of polyphenolic antioxidants during domestication, providing valuable insights for metabolism-assisted fortification of crop nutrition.
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title_short	Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds
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Metabolomic Analysis Reveals Domestication-Driven Reshaping of Polyphenolic Antioxidants in Soybean Seeds

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