Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer

Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc...
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Autor*in:	Mohammad A. Shatat [verfasserIn] Betsy Gauthier [verfasserIn] Suzy Yoon [verfasserIn] Eric Yuan [verfasserIn] Peiying Yang [verfasserIn] Goutham Narla [verfasserIn] Afshin Dowlati [verfasserIn] Richard T. Lee [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	mistletoe MYC natural products small‐cell lung cancer targeted therapy

Übergeordnetes Werk:	In: Cancer Medicine - Wiley, 2012, 12(2023), 7, Seite 8378-8387
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:7 ; pages:8378-8387

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/cam4.5558

Katalog-ID:	DOAJ089926315

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520			\|a Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression.
650		4	\|a mistletoe
650		4	\|a MYC
650		4	\|a natural products
650		4	\|a small‐cell lung cancer
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a Betsy Gauthier \|e verfasserin \|4 aut
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700	0		\|a Eric Yuan \|e verfasserin \|4 aut
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700	0		\|a Goutham Narla \|e verfasserin \|4 aut
700	0		\|a Afshin Dowlati \|e verfasserin \|4 aut
700	0		\|a Richard T. Lee \|e verfasserin \|4 aut
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allfields	10.1002/cam4.5558 doi (DE-627)DOAJ089926315 (DE-599)DOAJ47d4d8de8a9249e683d144928f16b31a DE-627 ger DE-627 rakwb eng RC254-282 Mohammad A. Shatat verfasserin aut Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression. mistletoe MYC natural products small‐cell lung cancer targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Betsy Gauthier verfasserin aut Suzy Yoon verfasserin aut Eric Yuan verfasserin aut Peiying Yang verfasserin aut Goutham Narla verfasserin aut Afshin Dowlati verfasserin aut Richard T. Lee verfasserin aut In Cancer Medicine Wiley, 2012 12(2023), 7, Seite 8378-8387 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:12 year:2023 number:7 pages:8378-8387 https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/article/47d4d8de8a9249e683d144928f16b31a kostenfrei https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7 8378-8387
spelling	10.1002/cam4.5558 doi (DE-627)DOAJ089926315 (DE-599)DOAJ47d4d8de8a9249e683d144928f16b31a DE-627 ger DE-627 rakwb eng RC254-282 Mohammad A. Shatat verfasserin aut Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression. mistletoe MYC natural products small‐cell lung cancer targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Betsy Gauthier verfasserin aut Suzy Yoon verfasserin aut Eric Yuan verfasserin aut Peiying Yang verfasserin aut Goutham Narla verfasserin aut Afshin Dowlati verfasserin aut Richard T. Lee verfasserin aut In Cancer Medicine Wiley, 2012 12(2023), 7, Seite 8378-8387 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:12 year:2023 number:7 pages:8378-8387 https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/article/47d4d8de8a9249e683d144928f16b31a kostenfrei https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7 8378-8387
allfields_unstemmed	10.1002/cam4.5558 doi (DE-627)DOAJ089926315 (DE-599)DOAJ47d4d8de8a9249e683d144928f16b31a DE-627 ger DE-627 rakwb eng RC254-282 Mohammad A. Shatat verfasserin aut Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression. mistletoe MYC natural products small‐cell lung cancer targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Betsy Gauthier verfasserin aut Suzy Yoon verfasserin aut Eric Yuan verfasserin aut Peiying Yang verfasserin aut Goutham Narla verfasserin aut Afshin Dowlati verfasserin aut Richard T. Lee verfasserin aut In Cancer Medicine Wiley, 2012 12(2023), 7, Seite 8378-8387 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:12 year:2023 number:7 pages:8378-8387 https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/article/47d4d8de8a9249e683d144928f16b31a kostenfrei https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7 8378-8387
allfieldsGer	10.1002/cam4.5558 doi (DE-627)DOAJ089926315 (DE-599)DOAJ47d4d8de8a9249e683d144928f16b31a DE-627 ger DE-627 rakwb eng RC254-282 Mohammad A. Shatat verfasserin aut Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression. mistletoe MYC natural products small‐cell lung cancer targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Betsy Gauthier verfasserin aut Suzy Yoon verfasserin aut Eric Yuan verfasserin aut Peiying Yang verfasserin aut Goutham Narla verfasserin aut Afshin Dowlati verfasserin aut Richard T. Lee verfasserin aut In Cancer Medicine Wiley, 2012 12(2023), 7, Seite 8378-8387 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:12 year:2023 number:7 pages:8378-8387 https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/article/47d4d8de8a9249e683d144928f16b31a kostenfrei https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7 8378-8387
allfieldsSound	10.1002/cam4.5558 doi (DE-627)DOAJ089926315 (DE-599)DOAJ47d4d8de8a9249e683d144928f16b31a DE-627 ger DE-627 rakwb eng RC254-282 Mohammad A. Shatat verfasserin aut Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression. mistletoe MYC natural products small‐cell lung cancer targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens Betsy Gauthier verfasserin aut Suzy Yoon verfasserin aut Eric Yuan verfasserin aut Peiying Yang verfasserin aut Goutham Narla verfasserin aut Afshin Dowlati verfasserin aut Richard T. Lee verfasserin aut In Cancer Medicine Wiley, 2012 12(2023), 7, Seite 8378-8387 (DE-627)71860153X (DE-600)2659751-2 20457634 nnns volume:12 year:2023 number:7 pages:8378-8387 https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/article/47d4d8de8a9249e683d144928f16b31a kostenfrei https://doi.org/10.1002/cam4.5558 kostenfrei https://doaj.org/toc/2045-7634 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 7 8378-8387
language	English
source	In Cancer Medicine 12(2023), 7, Seite 8378-8387 volume:12 year:2023 number:7 pages:8378-8387
sourceStr	In Cancer Medicine 12(2023), 7, Seite 8378-8387 volume:12 year:2023 number:7 pages:8378-8387
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	mistletoe MYC natural products small‐cell lung cancer targeted therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancer Medicine
authorswithroles_txt_mv	Mohammad A. Shatat @@aut@@ Betsy Gauthier @@aut@@ Suzy Yoon @@aut@@ Eric Yuan @@aut@@ Peiying Yang @@aut@@ Goutham Narla @@aut@@ Afshin Dowlati @@aut@@ Richard T. Lee @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	71860153X
id	DOAJ089926315
language_de	englisch
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Shatat</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. 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callnumber-first	R - Medicine
author	Mohammad A. Shatat
spellingShingle	Mohammad A. Shatat misc RC254-282 misc mistletoe misc MYC misc natural products misc small‐cell lung cancer misc targeted therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer
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topic_title	RC254-282 Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer mistletoe MYC natural products small‐cell lung cancer targeted therapy
topic	misc RC254-282 misc mistletoe misc MYC misc natural products misc small‐cell lung cancer misc targeted therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc mistletoe misc MYC misc natural products misc small‐cell lung cancer misc targeted therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer
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title_full	Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer
author_sort	Mohammad A. Shatat
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author_browse	Mohammad A. Shatat Betsy Gauthier Suzy Yoon Eric Yuan Peiying Yang Goutham Narla Afshin Dowlati Richard T. Lee
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author-letter	Mohammad A. Shatat
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title_sort	mistletoe lectin inhibits growth of myc‐amplified small‐cell lung cancer
callnumber	RC254-282
title_auth	Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer
abstract	Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression.
abstractGer	Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression.
abstract_unstemmed	Abstract Background Small‐cell lung cancer (SCLC) is the deadliest form of lung cancer but lacks targeted therapies. Methods We studied the effect of the natural product mistletoe lectin (ML) in pre‐clinical models of SCLC, focusing on cell lines with amplification of the myc family oncogenes C‐myc and N‐myc. Results We found that ML treatment inhibits growth of SCLC cell lines in culture and induces apoptosis. ML treatment also decreases the expression of the amplified myc proteins. Over‐expression of either C‐myc or N‐myc results in enhanced SCLC cell sensitivity to ML. In a mouse xenograft model of SCLC, treatment with ML results in decreased tumor growth over 4 weeks with evidence of increased apoptosis in tumors from treated animals. Conclusion Overall, our results demonstrate that ML exhibits therapeutic potential in SCLC, that is at least partially dependent on myc protein expression.
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container_issue	7
title_short	Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer
url	https://doi.org/10.1002/cam4.5558 https://doaj.org/article/47d4d8de8a9249e683d144928f16b31a https://doaj.org/toc/2045-7634
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author2	Betsy Gauthier Suzy Yoon Eric Yuan Peiying Yang Goutham Narla Afshin Dowlati Richard T. Lee
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up_date	2024-07-04T01:13:39.374Z
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Mistletoe lectin inhibits growth of Myc‐amplified small‐cell lung cancer

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