New cell sources for CAR-based immunotherapy

Abstract Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products current...
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Autor*in:	Marzieh Mazinani [verfasserIn] Fatemeh Rahbarizadeh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Chimeric antigen receptors Regulatory T cells γδT cells Mucosal-associated invariant T cells Natural killer T cells Natural killer cells

Übergeordnetes Werk:	In: Biomarker Research - BMC, 2014, 11(2023), 1, Seite 27
Übergeordnetes Werk:	volume:11 ; year:2023 ; number:1 ; pages:27

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s40364-023-00482-9

Katalog-ID:	DOAJ090052498

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callnumber-first	R - Medicine
author	Marzieh Mazinani
spellingShingle	Marzieh Mazinani misc RM1-950 misc Chimeric antigen receptors misc Regulatory T cells misc γδT cells misc Mucosal-associated invariant T cells misc Natural killer T cells misc Natural killer cells misc Therapeutics. Pharmacology New cell sources for CAR-based immunotherapy
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topic_title	RM1-950 New cell sources for CAR-based immunotherapy Chimeric antigen receptors Regulatory T cells γδT cells Mucosal-associated invariant T cells Natural killer T cells Natural killer cells
topic	misc RM1-950 misc Chimeric antigen receptors misc Regulatory T cells misc γδT cells misc Mucosal-associated invariant T cells misc Natural killer T cells misc Natural killer cells misc Therapeutics. Pharmacology
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title	New cell sources for CAR-based immunotherapy
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title_sort	new cell sources for car-based immunotherapy
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title_auth	New cell sources for CAR-based immunotherapy
abstract	Abstract Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products currently available in the market. Despite impressive clinical outcomes, concerns about treatment failure associated with low efficacy or high cytotoxicity of CAR-T cells remain. While the main focus has been on improving CAR-T cells, exploring alternative cellular sources for CAR generation has garnered growing interest. In the current review, we comprehensively evaluated other cell sources rather than conventional T cells for CAR generation.
abstractGer	Abstract Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products currently available in the market. Despite impressive clinical outcomes, concerns about treatment failure associated with low efficacy or high cytotoxicity of CAR-T cells remain. While the main focus has been on improving CAR-T cells, exploring alternative cellular sources for CAR generation has garnered growing interest. In the current review, we comprehensively evaluated other cell sources rather than conventional T cells for CAR generation.
abstract_unstemmed	Abstract Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in six FDA-approved CAR-T products currently available in the market. Despite impressive clinical outcomes, concerns about treatment failure associated with low efficacy or high cytotoxicity of CAR-T cells remain. While the main focus has been on improving CAR-T cells, exploring alternative cellular sources for CAR generation has garnered growing interest. In the current review, we comprehensively evaluated other cell sources rather than conventional T cells for CAR generation.
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title_short	New cell sources for CAR-based immunotherapy
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