Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes
Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characteri...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Barbara Oliviero [verfasserIn] Michele Dei Cas [verfasserIn] Aida Zulueta [verfasserIn] Roberta Maiello [verfasserIn] Alessandro Villa [verfasserIn] Carla Martinelli [verfasserIn] Elena Del Favero [verfasserIn] Monica Falleni [verfasserIn] Linda Montavoci [verfasserIn] Stefania Varchetta [verfasserIn] Dalila Mele [verfasserIn] Matteo Donadon [verfasserIn] Cristiana Soldani [verfasserIn] Barbara Franceschini [verfasserIn] Marcello Maestri [verfasserIn] Gaetano Piccolo [verfasserIn] Matteo Barabino [verfasserIn] Paolo Pietro Bianchi [verfasserIn] Jesus M. Banales [verfasserIn] Stefania Mantovani [verfasserIn] Mario U. Mondelli [verfasserIn] Anna Caretti [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Übergeordnetes Werk: |
In: Scientific Reports - Nature Portfolio, 2011, 13(2023), 1, Seite 10 |
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| Übergeordnetes Werk: |
volume:13 ; year:2023 ; number:1 ; pages:10 |
| Links: |
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| DOI / URN: |
10.1038/s41598-023-34676-w |
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| Katalog-ID: |
DOAJ090276833 |
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| 520 | |a Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. | ||
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10.1038/s41598-023-34676-w doi (DE-627)DOAJ090276833 (DE-599)DOAJbb75d917f167424e9b8d30fa461784d6 DE-627 ger DE-627 rakwb eng Barbara Oliviero verfasserin aut Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. Medicine R Science Q Michele Dei Cas verfasserin aut Aida Zulueta verfasserin aut Roberta Maiello verfasserin aut Alessandro Villa verfasserin aut Carla Martinelli verfasserin aut Elena Del Favero verfasserin aut Monica Falleni verfasserin aut Linda Montavoci verfasserin aut Stefania Varchetta verfasserin aut Dalila Mele verfasserin aut Matteo Donadon verfasserin aut Cristiana Soldani verfasserin aut Barbara Franceschini verfasserin aut Marcello Maestri verfasserin aut Gaetano Piccolo verfasserin aut Matteo Barabino verfasserin aut Paolo Pietro Bianchi verfasserin aut Jesus M. Banales verfasserin aut Stefania Mantovani verfasserin aut Mario U. Mondelli verfasserin aut Anna Caretti verfasserin aut In Scientific Reports Nature Portfolio, 2011 13(2023), 1, Seite 10 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:13 year:2023 number:1 pages:10 https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/article/bb75d917f167424e9b8d30fa461784d6 kostenfrei https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 10 |
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10.1038/s41598-023-34676-w doi (DE-627)DOAJ090276833 (DE-599)DOAJbb75d917f167424e9b8d30fa461784d6 DE-627 ger DE-627 rakwb eng Barbara Oliviero verfasserin aut Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. Medicine R Science Q Michele Dei Cas verfasserin aut Aida Zulueta verfasserin aut Roberta Maiello verfasserin aut Alessandro Villa verfasserin aut Carla Martinelli verfasserin aut Elena Del Favero verfasserin aut Monica Falleni verfasserin aut Linda Montavoci verfasserin aut Stefania Varchetta verfasserin aut Dalila Mele verfasserin aut Matteo Donadon verfasserin aut Cristiana Soldani verfasserin aut Barbara Franceschini verfasserin aut Marcello Maestri verfasserin aut Gaetano Piccolo verfasserin aut Matteo Barabino verfasserin aut Paolo Pietro Bianchi verfasserin aut Jesus M. Banales verfasserin aut Stefania Mantovani verfasserin aut Mario U. Mondelli verfasserin aut Anna Caretti verfasserin aut In Scientific Reports Nature Portfolio, 2011 13(2023), 1, Seite 10 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:13 year:2023 number:1 pages:10 https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/article/bb75d917f167424e9b8d30fa461784d6 kostenfrei https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 10 |
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10.1038/s41598-023-34676-w doi (DE-627)DOAJ090276833 (DE-599)DOAJbb75d917f167424e9b8d30fa461784d6 DE-627 ger DE-627 rakwb eng Barbara Oliviero verfasserin aut Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. Medicine R Science Q Michele Dei Cas verfasserin aut Aida Zulueta verfasserin aut Roberta Maiello verfasserin aut Alessandro Villa verfasserin aut Carla Martinelli verfasserin aut Elena Del Favero verfasserin aut Monica Falleni verfasserin aut Linda Montavoci verfasserin aut Stefania Varchetta verfasserin aut Dalila Mele verfasserin aut Matteo Donadon verfasserin aut Cristiana Soldani verfasserin aut Barbara Franceschini verfasserin aut Marcello Maestri verfasserin aut Gaetano Piccolo verfasserin aut Matteo Barabino verfasserin aut Paolo Pietro Bianchi verfasserin aut Jesus M. Banales verfasserin aut Stefania Mantovani verfasserin aut Mario U. Mondelli verfasserin aut Anna Caretti verfasserin aut In Scientific Reports Nature Portfolio, 2011 13(2023), 1, Seite 10 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:13 year:2023 number:1 pages:10 https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/article/bb75d917f167424e9b8d30fa461784d6 kostenfrei https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 10 |
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10.1038/s41598-023-34676-w doi (DE-627)DOAJ090276833 (DE-599)DOAJbb75d917f167424e9b8d30fa461784d6 DE-627 ger DE-627 rakwb eng Barbara Oliviero verfasserin aut Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. Medicine R Science Q Michele Dei Cas verfasserin aut Aida Zulueta verfasserin aut Roberta Maiello verfasserin aut Alessandro Villa verfasserin aut Carla Martinelli verfasserin aut Elena Del Favero verfasserin aut Monica Falleni verfasserin aut Linda Montavoci verfasserin aut Stefania Varchetta verfasserin aut Dalila Mele verfasserin aut Matteo Donadon verfasserin aut Cristiana Soldani verfasserin aut Barbara Franceschini verfasserin aut Marcello Maestri verfasserin aut Gaetano Piccolo verfasserin aut Matteo Barabino verfasserin aut Paolo Pietro Bianchi verfasserin aut Jesus M. Banales verfasserin aut Stefania Mantovani verfasserin aut Mario U. Mondelli verfasserin aut Anna Caretti verfasserin aut In Scientific Reports Nature Portfolio, 2011 13(2023), 1, Seite 10 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:13 year:2023 number:1 pages:10 https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/article/bb75d917f167424e9b8d30fa461784d6 kostenfrei https://doi.org/10.1038/s41598-023-34676-w kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 1 10 |
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Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes |
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Barbara Oliviero |
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Scientific Reports |
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Barbara Oliviero Michele Dei Cas Aida Zulueta Roberta Maiello Alessandro Villa Carla Martinelli Elena Del Favero Monica Falleni Linda Montavoci Stefania Varchetta Dalila Mele Matteo Donadon Cristiana Soldani Barbara Franceschini Marcello Maestri Gaetano Piccolo Matteo Barabino Paolo Pietro Bianchi Jesus M. Banales Stefania Mantovani Mario U. Mondelli Anna Caretti |
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Elektronische Aufsätze |
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ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes |
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Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes |
| abstract |
Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. |
| abstractGer |
Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. |
| abstract_unstemmed |
Abstract Cholangiocarcinoma (CCA) is a rare cancer characterized by a global increasing incidence. Extracellular vesicles (EV) contribute to many of the hallmarks of cancer through transfer of their cargo molecules. The sphingolipid (SPL) profile of intrahepatic CCA (iCCA)-derived EVs was characterized by liquid chromatography-tandem mass spectrometry analysis. The effect of iCCA-derived EVs as mediators of inflammation was assessed on monocytes by flow cytometry. iCCA-derived EVs showed downregulation of all SPL species. Of note, poorly-differentiated iCCA-derived EVs showed a higher ceramide and dihydroceramide content compared with moderately-differentiated iCCA-derived EVs. Of note, higher dihydroceramide content was associated with vascular invasion. Cancer-derived EVs induced the release of pro-inflammatory cytokines in monocytes. Inhibition of synthesis of ceramide with Myriocin, a specific inhibitor of the serine palmitoyl transferase, reduced the pro-inflammatory activity of iCCA-derived EVs, demonstrating a role for ceramide as mediator of inflammation in iCCA. In conclusion, iCCA-derived EVs may promote iCCA progression by exporting the excess of pro-apoptotic and pro-inflammatory ceramides. |
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Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes |
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https://doi.org/10.1038/s41598-023-34676-w https://doaj.org/article/bb75d917f167424e9b8d30fa461784d6 https://doaj.org/toc/2045-2322 |
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Michele Dei Cas Aida Zulueta Roberta Maiello Alessandro Villa Carla Martinelli Elena Del Favero Monica Falleni Linda Montavoci Stefania Varchetta Dalila Mele Matteo Donadon Cristiana Soldani Barbara Franceschini Marcello Maestri Gaetano Piccolo Matteo Barabino Paolo Pietro Bianchi Jesus M. Banales Stefania Mantovani Mario U. Mondelli Anna Caretti |
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