Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation

Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole...
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Autor*in:	Renhao Ni [verfasserIn] Lingjing Jiang [verfasserIn] Chaohai Zhang [verfasserIn] Mujie Liu [verfasserIn] Yang Luo [verfasserIn] Zeming Hu [verfasserIn] Xianbo Mou [verfasserIn] Yabin Zhu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	inflammation macrophage phenotype cellular signal biologic mechanism

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 9, p 8358
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:9, p 8358

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms24098358

Katalog-ID:	DOAJ090362187

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520			\|a Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole inflammation stage, involving the transduction of intracellular signals and the secretion of extracellular cytokines. This paper aims to address the interaction of macrophages and surrounding cells and tissues with inflammation-related diseases and clarify the crosstalk of signal pathways relevant to the phenotypic metamorphosis of macrophages. On these bases, some novel therapeutic methods are proposed for regulating inflammation through monitoring the transition of macrophage phenotypes so as to prevent the negative effects of antibiotic drugs utilized in the long term in the clinic. This information will be quite beneficial for the diagnosis and treatment of inflammation-related diseases like pneumonia and other disorders involving macrophages.
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allfields	10.3390/ijms24098358 doi (DE-627)DOAJ090362187 (DE-599)DOAJ30119a0742154656b5f04f1555542b32 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Renhao Ni verfasserin aut Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole inflammation stage, involving the transduction of intracellular signals and the secretion of extracellular cytokines. This paper aims to address the interaction of macrophages and surrounding cells and tissues with inflammation-related diseases and clarify the crosstalk of signal pathways relevant to the phenotypic metamorphosis of macrophages. On these bases, some novel therapeutic methods are proposed for regulating inflammation through monitoring the transition of macrophage phenotypes so as to prevent the negative effects of antibiotic drugs utilized in the long term in the clinic. This information will be quite beneficial for the diagnosis and treatment of inflammation-related diseases like pneumonia and other disorders involving macrophages. inflammation macrophage phenotype cellular signal biologic mechanism Biology (General) Chemistry Lingjing Jiang verfasserin aut Chaohai Zhang verfasserin aut Mujie Liu verfasserin aut Yang Luo verfasserin aut Zeming Hu verfasserin aut Xianbo Mou verfasserin aut Yabin Zhu verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 9, p 8358 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:9, p 8358 https://doi.org/10.3390/ijms24098358 kostenfrei https://doaj.org/article/30119a0742154656b5f04f1555542b32 kostenfrei https://www.mdpi.com/1422-0067/24/9/8358 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 9, p 8358
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allfieldsSound	10.3390/ijms24098358 doi (DE-627)DOAJ090362187 (DE-599)DOAJ30119a0742154656b5f04f1555542b32 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Renhao Ni verfasserin aut Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole inflammation stage, involving the transduction of intracellular signals and the secretion of extracellular cytokines. This paper aims to address the interaction of macrophages and surrounding cells and tissues with inflammation-related diseases and clarify the crosstalk of signal pathways relevant to the phenotypic metamorphosis of macrophages. On these bases, some novel therapeutic methods are proposed for regulating inflammation through monitoring the transition of macrophage phenotypes so as to prevent the negative effects of antibiotic drugs utilized in the long term in the clinic. This information will be quite beneficial for the diagnosis and treatment of inflammation-related diseases like pneumonia and other disorders involving macrophages. inflammation macrophage phenotype cellular signal biologic mechanism Biology (General) Chemistry Lingjing Jiang verfasserin aut Chaohai Zhang verfasserin aut Mujie Liu verfasserin aut Yang Luo verfasserin aut Zeming Hu verfasserin aut Xianbo Mou verfasserin aut Yabin Zhu verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 9, p 8358 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:9, p 8358 https://doi.org/10.3390/ijms24098358 kostenfrei https://doaj.org/article/30119a0742154656b5f04f1555542b32 kostenfrei https://www.mdpi.com/1422-0067/24/9/8358 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 9, p 8358
language	English
source	In International Journal of Molecular Sciences 24(2023), 9, p 8358 volume:24 year:2023 number:9, p 8358
sourceStr	In International Journal of Molecular Sciences 24(2023), 9, p 8358 volume:24 year:2023 number:9, p 8358
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	inflammation macrophage phenotype cellular signal biologic mechanism Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Renhao Ni @@aut@@ Lingjing Jiang @@aut@@ Chaohai Zhang @@aut@@ Mujie Liu @@aut@@ Yang Luo @@aut@@ Zeming Hu @@aut@@ Xianbo Mou @@aut@@ Yabin Zhu @@aut@@
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author	Renhao Ni
spellingShingle	Renhao Ni misc QH301-705.5 misc QD1-999 misc inflammation misc macrophage phenotype misc cellular signal misc biologic mechanism misc Biology (General) misc Chemistry Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation
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topic_title	QH301-705.5 QD1-999 Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation inflammation macrophage phenotype cellular signal biologic mechanism
topic	misc QH301-705.5 misc QD1-999 misc inflammation misc macrophage phenotype misc cellular signal misc biologic mechanism misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc inflammation misc macrophage phenotype misc cellular signal misc biologic mechanism misc Biology (General) misc Chemistry
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title	Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation
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title_sort	biologic mechanisms of macrophage phenotypes responding to infection and the novel therapies to moderate inflammation
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title_auth	Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation
abstract	Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole inflammation stage, involving the transduction of intracellular signals and the secretion of extracellular cytokines. This paper aims to address the interaction of macrophages and surrounding cells and tissues with inflammation-related diseases and clarify the crosstalk of signal pathways relevant to the phenotypic metamorphosis of macrophages. On these bases, some novel therapeutic methods are proposed for regulating inflammation through monitoring the transition of macrophage phenotypes so as to prevent the negative effects of antibiotic drugs utilized in the long term in the clinic. This information will be quite beneficial for the diagnosis and treatment of inflammation-related diseases like pneumonia and other disorders involving macrophages.
abstractGer	Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole inflammation stage, involving the transduction of intracellular signals and the secretion of extracellular cytokines. This paper aims to address the interaction of macrophages and surrounding cells and tissues with inflammation-related diseases and clarify the crosstalk of signal pathways relevant to the phenotypic metamorphosis of macrophages. On these bases, some novel therapeutic methods are proposed for regulating inflammation through monitoring the transition of macrophage phenotypes so as to prevent the negative effects of antibiotic drugs utilized in the long term in the clinic. This information will be quite beneficial for the diagnosis and treatment of inflammation-related diseases like pneumonia and other disorders involving macrophages.
abstract_unstemmed	Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated; both phenotypes usually coexist throughout the whole inflammation stage, involving the transduction of intracellular signals and the secretion of extracellular cytokines. This paper aims to address the interaction of macrophages and surrounding cells and tissues with inflammation-related diseases and clarify the crosstalk of signal pathways relevant to the phenotypic metamorphosis of macrophages. On these bases, some novel therapeutic methods are proposed for regulating inflammation through monitoring the transition of macrophage phenotypes so as to prevent the negative effects of antibiotic drugs utilized in the long term in the clinic. This information will be quite beneficial for the diagnosis and treatment of inflammation-related diseases like pneumonia and other disorders involving macrophages.
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container_issue	9, p 8358
title_short	Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation
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