Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review

Secondary caries is one of the leading causes of resin-based dental restoration failure. It is initiated at the interface of an existing restoration and the restored tooth surface. It is mainly caused by an imbalance between two processes of mineral loss (demineralization) and mineral gain (reminera...
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Autor*in:	Leena Ibraheem Bin-Jardan [verfasserIn] Dalal Ibrahim Almadani [verfasserIn] Leen Saleh Almutairi [verfasserIn] Hadi A. Almoabid [verfasserIn] Mohammed A. Alessa [verfasserIn] Khalid S. Almulhim [verfasserIn] Rasha N. AlSheikh [verfasserIn] Yousif A. Al-Dulaijan [verfasserIn] Maria S. Ibrahim [verfasserIn] Afnan O. Al-Zain [verfasserIn] Abdulrahman A. Balhaddad [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	biofilm bioactive dental secondary caries resin composite

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 9, p 8295
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:9, p 8295

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms24098295

Katalog-ID:	DOAJ090362772

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allfields_unstemmed	10.3390/ijms24098295 doi (DE-627)DOAJ090362772 (DE-599)DOAJ8cf0bcd21baf4082a726375ab29a7c36 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Leena Ibraheem Bin-Jardan verfasserin aut Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Secondary caries is one of the leading causes of resin-based dental restoration failure. It is initiated at the interface of an existing restoration and the restored tooth surface. It is mainly caused by an imbalance between two processes of mineral loss (demineralization) and mineral gain (remineralization). A plethora of evidence has explored incorporating several bioactive compounds into resin-based materials to prevent bacterial biofilm attachment and the onset of the disease. In this review, the most recent advances in the design of remineralizing compounds and their functionalization to different resin-based materials’ formulations were overviewed. Inorganic compounds, such as nano-sized amorphous calcium phosphate (NACP), calcium fluoride (CaF<sub<2</sub<), bioactive glass (BAG), hydroxyapatite (HA), fluorapatite (FA), and boron nitride (BN), displayed promising results concerning remineralization, and direct and indirect impact on biofilm growth. The effects of these compounds varied based on these compounds’ structure, the incorporated amount or percentage, and the intended clinical application. The remineralizing effects were presented as direct effects, such as an increase in the mineral content of the dental tissue, or indirect effects, such as an increase in the pH around the material. In some of the reported investigations, inorganic remineralizing compounds were combined with other bioactive agents, such as quaternary ammonium compounds (QACs), to maximize the remineralization outcomes and the antibacterial action against the cariogenic biofilms. The reviewed literature was mainly based on laboratory studies, highlighting the need to shift more toward testing the performance of these remineralizing compounds in clinical settings. biofilm bioactive dental secondary caries resin composite Biology (General) Chemistry Dalal Ibrahim Almadani verfasserin aut Leen Saleh Almutairi verfasserin aut Hadi A. Almoabid verfasserin aut Mohammed A. Alessa verfasserin aut Khalid S. Almulhim verfasserin aut Rasha N. AlSheikh verfasserin aut Yousif A. Al-Dulaijan verfasserin aut Maria S. Ibrahim verfasserin aut Afnan O. Al-Zain verfasserin aut Abdulrahman A. Balhaddad verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 9, p 8295 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:9, p 8295 https://doi.org/10.3390/ijms24098295 kostenfrei https://doaj.org/article/8cf0bcd21baf4082a726375ab29a7c36 kostenfrei https://www.mdpi.com/1422-0067/24/9/8295 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 9, p 8295
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allfieldsSound	10.3390/ijms24098295 doi (DE-627)DOAJ090362772 (DE-599)DOAJ8cf0bcd21baf4082a726375ab29a7c36 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Leena Ibraheem Bin-Jardan verfasserin aut Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Secondary caries is one of the leading causes of resin-based dental restoration failure. It is initiated at the interface of an existing restoration and the restored tooth surface. It is mainly caused by an imbalance between two processes of mineral loss (demineralization) and mineral gain (remineralization). A plethora of evidence has explored incorporating several bioactive compounds into resin-based materials to prevent bacterial biofilm attachment and the onset of the disease. In this review, the most recent advances in the design of remineralizing compounds and their functionalization to different resin-based materials’ formulations were overviewed. Inorganic compounds, such as nano-sized amorphous calcium phosphate (NACP), calcium fluoride (CaF<sub<2</sub<), bioactive glass (BAG), hydroxyapatite (HA), fluorapatite (FA), and boron nitride (BN), displayed promising results concerning remineralization, and direct and indirect impact on biofilm growth. The effects of these compounds varied based on these compounds’ structure, the incorporated amount or percentage, and the intended clinical application. The remineralizing effects were presented as direct effects, such as an increase in the mineral content of the dental tissue, or indirect effects, such as an increase in the pH around the material. In some of the reported investigations, inorganic remineralizing compounds were combined with other bioactive agents, such as quaternary ammonium compounds (QACs), to maximize the remineralization outcomes and the antibacterial action against the cariogenic biofilms. The reviewed literature was mainly based on laboratory studies, highlighting the need to shift more toward testing the performance of these remineralizing compounds in clinical settings. biofilm bioactive dental secondary caries resin composite Biology (General) Chemistry Dalal Ibrahim Almadani verfasserin aut Leen Saleh Almutairi verfasserin aut Hadi A. Almoabid verfasserin aut Mohammed A. Alessa verfasserin aut Khalid S. Almulhim verfasserin aut Rasha N. AlSheikh verfasserin aut Yousif A. Al-Dulaijan verfasserin aut Maria S. Ibrahim verfasserin aut Afnan O. Al-Zain verfasserin aut Abdulrahman A. Balhaddad verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 9, p 8295 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:9, p 8295 https://doi.org/10.3390/ijms24098295 kostenfrei https://doaj.org/article/8cf0bcd21baf4082a726375ab29a7c36 kostenfrei https://www.mdpi.com/1422-0067/24/9/8295 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 9, p 8295
language	English
source	In International Journal of Molecular Sciences 24(2023), 9, p 8295 volume:24 year:2023 number:9, p 8295
sourceStr	In International Journal of Molecular Sciences 24(2023), 9, p 8295 volume:24 year:2023 number:9, p 8295
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	biofilm bioactive dental secondary caries resin composite Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Leena Ibraheem Bin-Jardan @@aut@@ Dalal Ibrahim Almadani @@aut@@ Leen Saleh Almutairi @@aut@@ Hadi A. Almoabid @@aut@@ Mohammed A. Alessa @@aut@@ Khalid S. Almulhim @@aut@@ Rasha N. AlSheikh @@aut@@ Yousif A. Al-Dulaijan @@aut@@ Maria S. Ibrahim @@aut@@ Afnan O. Al-Zain @@aut@@ Abdulrahman A. Balhaddad @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ090362772
language_de	englisch
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callnumber-first	Q - Science
author	Leena Ibraheem Bin-Jardan
spellingShingle	Leena Ibraheem Bin-Jardan misc QH301-705.5 misc QD1-999 misc biofilm misc bioactive misc dental misc secondary caries misc resin composite misc Biology (General) misc Chemistry Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review
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topic_title	QH301-705.5 QD1-999 Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review biofilm bioactive dental secondary caries resin composite
topic	misc QH301-705.5 misc QD1-999 misc biofilm misc bioactive misc dental misc secondary caries misc resin composite misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc biofilm misc bioactive misc dental misc secondary caries misc resin composite misc Biology (General) misc Chemistry
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title	Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review
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author_browse	Leena Ibraheem Bin-Jardan Dalal Ibrahim Almadani Leen Saleh Almutairi Hadi A. Almoabid Mohammed A. Alessa Khalid S. Almulhim Rasha N. AlSheikh Yousif A. Al-Dulaijan Maria S. Ibrahim Afnan O. Al-Zain Abdulrahman A. Balhaddad
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title_sort	inorganic compounds as remineralizing fillers in dental restorative materials: narrative review
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title_auth	Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review
abstract	Secondary caries is one of the leading causes of resin-based dental restoration failure. It is initiated at the interface of an existing restoration and the restored tooth surface. It is mainly caused by an imbalance between two processes of mineral loss (demineralization) and mineral gain (remineralization). A plethora of evidence has explored incorporating several bioactive compounds into resin-based materials to prevent bacterial biofilm attachment and the onset of the disease. In this review, the most recent advances in the design of remineralizing compounds and their functionalization to different resin-based materials’ formulations were overviewed. Inorganic compounds, such as nano-sized amorphous calcium phosphate (NACP), calcium fluoride (CaF<sub<2</sub<), bioactive glass (BAG), hydroxyapatite (HA), fluorapatite (FA), and boron nitride (BN), displayed promising results concerning remineralization, and direct and indirect impact on biofilm growth. The effects of these compounds varied based on these compounds’ structure, the incorporated amount or percentage, and the intended clinical application. The remineralizing effects were presented as direct effects, such as an increase in the mineral content of the dental tissue, or indirect effects, such as an increase in the pH around the material. In some of the reported investigations, inorganic remineralizing compounds were combined with other bioactive agents, such as quaternary ammonium compounds (QACs), to maximize the remineralization outcomes and the antibacterial action against the cariogenic biofilms. The reviewed literature was mainly based on laboratory studies, highlighting the need to shift more toward testing the performance of these remineralizing compounds in clinical settings.
abstractGer	Secondary caries is one of the leading causes of resin-based dental restoration failure. It is initiated at the interface of an existing restoration and the restored tooth surface. It is mainly caused by an imbalance between two processes of mineral loss (demineralization) and mineral gain (remineralization). A plethora of evidence has explored incorporating several bioactive compounds into resin-based materials to prevent bacterial biofilm attachment and the onset of the disease. In this review, the most recent advances in the design of remineralizing compounds and their functionalization to different resin-based materials’ formulations were overviewed. Inorganic compounds, such as nano-sized amorphous calcium phosphate (NACP), calcium fluoride (CaF<sub<2</sub<), bioactive glass (BAG), hydroxyapatite (HA), fluorapatite (FA), and boron nitride (BN), displayed promising results concerning remineralization, and direct and indirect impact on biofilm growth. The effects of these compounds varied based on these compounds’ structure, the incorporated amount or percentage, and the intended clinical application. The remineralizing effects were presented as direct effects, such as an increase in the mineral content of the dental tissue, or indirect effects, such as an increase in the pH around the material. In some of the reported investigations, inorganic remineralizing compounds were combined with other bioactive agents, such as quaternary ammonium compounds (QACs), to maximize the remineralization outcomes and the antibacterial action against the cariogenic biofilms. The reviewed literature was mainly based on laboratory studies, highlighting the need to shift more toward testing the performance of these remineralizing compounds in clinical settings.
abstract_unstemmed	Secondary caries is one of the leading causes of resin-based dental restoration failure. It is initiated at the interface of an existing restoration and the restored tooth surface. It is mainly caused by an imbalance between two processes of mineral loss (demineralization) and mineral gain (remineralization). A plethora of evidence has explored incorporating several bioactive compounds into resin-based materials to prevent bacterial biofilm attachment and the onset of the disease. In this review, the most recent advances in the design of remineralizing compounds and their functionalization to different resin-based materials’ formulations were overviewed. Inorganic compounds, such as nano-sized amorphous calcium phosphate (NACP), calcium fluoride (CaF<sub<2</sub<), bioactive glass (BAG), hydroxyapatite (HA), fluorapatite (FA), and boron nitride (BN), displayed promising results concerning remineralization, and direct and indirect impact on biofilm growth. The effects of these compounds varied based on these compounds’ structure, the incorporated amount or percentage, and the intended clinical application. The remineralizing effects were presented as direct effects, such as an increase in the mineral content of the dental tissue, or indirect effects, such as an increase in the pH around the material. In some of the reported investigations, inorganic remineralizing compounds were combined with other bioactive agents, such as quaternary ammonium compounds (QACs), to maximize the remineralization outcomes and the antibacterial action against the cariogenic biofilms. The reviewed literature was mainly based on laboratory studies, highlighting the need to shift more toward testing the performance of these remineralizing compounds in clinical settings.
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title_short	Inorganic Compounds as Remineralizing Fillers in Dental Restorative Materials: Narrative Review
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