The Values and Perspectives of Organoids in the Field of Metabolic Syndrome

Metabolic syndrome (MetS) has become a global health problem, and the prevalence of obesity at all stages of life makes MetS research increasingly important and urgent. However, as a comprehensive and complex disease, MetS has lacked more appropriate research models. The advent of organoids provides...
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Autor*in:	Chen Tan [verfasserIn] Min Ding [verfasserIn] Yun-Wen Zheng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	metabolic syndrome pancreatic organoids β-cells diabetes islet regeneration hepatobiliary organoids

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 9, p 8125
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:9, p 8125

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms24098125

Katalog-ID:	DOAJ090364503

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520			\|a Metabolic syndrome (MetS) has become a global health problem, and the prevalence of obesity at all stages of life makes MetS research increasingly important and urgent. However, as a comprehensive and complex disease, MetS has lacked more appropriate research models. The advent of organoids provides an opportunity to address this issue. However, it should be noted that organoids are still in their infancy. The main drawbacks are a lack of maturity, complexity, and the inability to standardize large-scale production. Could organoids therefore be a better choice for studying MetS than other models? How can these limitations be overcome? Here, we summarize the available data to present current progress on pancreatic and hepatobiliary organoids and to answer these open questions. Organoids are of human origin and contain a variety of human cell types necessary to mimic the disease characteristics of MetS in their development. Taken together with the discovery of hepatobiliary progenitors in situ, the dedifferentiation of beta cells in diabetes, and studies on hepatic macrophages, we suggest that promoting endogenous regeneration has the potential to prevent the development of end-stage liver and pancreatic lesions caused by MetS and outline the direction of future research in this field.
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language	English
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sourceStr	In International Journal of Molecular Sciences 24(2023), 9, p 8125 volume:24 year:2023 number:9, p 8125
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topic_facet	metabolic syndrome pancreatic organoids β-cells diabetes islet regeneration hepatobiliary organoids Biology (General) Chemistry
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authorswithroles_txt_mv	Chen Tan @@aut@@ Min Ding @@aut@@ Yun-Wen Zheng @@aut@@
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callnumber-first	Q - Science
author	Chen Tan
spellingShingle	Chen Tan misc QH301-705.5 misc QD1-999 misc metabolic syndrome misc pancreatic organoids misc β-cells misc diabetes misc islet regeneration misc hepatobiliary organoids misc Biology (General) misc Chemistry The Values and Perspectives of Organoids in the Field of Metabolic Syndrome
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topic_title	QH301-705.5 QD1-999 The Values and Perspectives of Organoids in the Field of Metabolic Syndrome metabolic syndrome pancreatic organoids β-cells diabetes islet regeneration hepatobiliary organoids
topic	misc QH301-705.5 misc QD1-999 misc metabolic syndrome misc pancreatic organoids misc β-cells misc diabetes misc islet regeneration misc hepatobiliary organoids misc Biology (General) misc Chemistry
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title	The Values and Perspectives of Organoids in the Field of Metabolic Syndrome
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title_sort	values and perspectives of organoids in the field of metabolic syndrome
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title_auth	The Values and Perspectives of Organoids in the Field of Metabolic Syndrome
abstract	Metabolic syndrome (MetS) has become a global health problem, and the prevalence of obesity at all stages of life makes MetS research increasingly important and urgent. However, as a comprehensive and complex disease, MetS has lacked more appropriate research models. The advent of organoids provides an opportunity to address this issue. However, it should be noted that organoids are still in their infancy. The main drawbacks are a lack of maturity, complexity, and the inability to standardize large-scale production. Could organoids therefore be a better choice for studying MetS than other models? How can these limitations be overcome? Here, we summarize the available data to present current progress on pancreatic and hepatobiliary organoids and to answer these open questions. Organoids are of human origin and contain a variety of human cell types necessary to mimic the disease characteristics of MetS in their development. Taken together with the discovery of hepatobiliary progenitors in situ, the dedifferentiation of beta cells in diabetes, and studies on hepatic macrophages, we suggest that promoting endogenous regeneration has the potential to prevent the development of end-stage liver and pancreatic lesions caused by MetS and outline the direction of future research in this field.
abstractGer	Metabolic syndrome (MetS) has become a global health problem, and the prevalence of obesity at all stages of life makes MetS research increasingly important and urgent. However, as a comprehensive and complex disease, MetS has lacked more appropriate research models. The advent of organoids provides an opportunity to address this issue. However, it should be noted that organoids are still in their infancy. The main drawbacks are a lack of maturity, complexity, and the inability to standardize large-scale production. Could organoids therefore be a better choice for studying MetS than other models? How can these limitations be overcome? Here, we summarize the available data to present current progress on pancreatic and hepatobiliary organoids and to answer these open questions. Organoids are of human origin and contain a variety of human cell types necessary to mimic the disease characteristics of MetS in their development. Taken together with the discovery of hepatobiliary progenitors in situ, the dedifferentiation of beta cells in diabetes, and studies on hepatic macrophages, we suggest that promoting endogenous regeneration has the potential to prevent the development of end-stage liver and pancreatic lesions caused by MetS and outline the direction of future research in this field.
abstract_unstemmed	Metabolic syndrome (MetS) has become a global health problem, and the prevalence of obesity at all stages of life makes MetS research increasingly important and urgent. However, as a comprehensive and complex disease, MetS has lacked more appropriate research models. The advent of organoids provides an opportunity to address this issue. However, it should be noted that organoids are still in their infancy. The main drawbacks are a lack of maturity, complexity, and the inability to standardize large-scale production. Could organoids therefore be a better choice for studying MetS than other models? How can these limitations be overcome? Here, we summarize the available data to present current progress on pancreatic and hepatobiliary organoids and to answer these open questions. Organoids are of human origin and contain a variety of human cell types necessary to mimic the disease characteristics of MetS in their development. Taken together with the discovery of hepatobiliary progenitors in situ, the dedifferentiation of beta cells in diabetes, and studies on hepatic macrophages, we suggest that promoting endogenous regeneration has the potential to prevent the development of end-stage liver and pancreatic lesions caused by MetS and outline the direction of future research in this field.
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title_short	The Values and Perspectives of Organoids in the Field of Metabolic Syndrome
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