Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology

Breast cancer is a heterogeneous disease which accounts globally for approximately 1 million new cases annually, wherein more than 200,000 of these cases turn out to be cases of triple-negative breast cancer (TNBC). TNBC is an aggressive and rare breast cancer subtype that accounts for 10–15% of all...
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Gespeichert in:

Autor*in:	Aiswarya Chaudhuri [verfasserIn] Dulla Naveen Kumar [verfasserIn] Deepa Dehari [verfasserIn] Rohit Patil [verfasserIn] Sanjay Singh [verfasserIn] Dinesh Kumar [verfasserIn] Ashish Kumar Agrawal [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	triple-negative breast cancer biomarkers nanoparticles targeted therapy personalized therapy

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 9, p 2661
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:9, p 2661

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15092661

Katalog-ID:	DOAJ090382412

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callnumber-first	R - Medicine
author	Aiswarya Chaudhuri
spellingShingle	Aiswarya Chaudhuri misc RC254-282 misc triple-negative breast cancer misc biomarkers misc nanoparticles misc targeted therapy misc personalized therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology
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topic_title	RC254-282 Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology triple-negative breast cancer biomarkers nanoparticles targeted therapy personalized therapy
topic	misc RC254-282 misc triple-negative breast cancer misc biomarkers misc nanoparticles misc targeted therapy misc personalized therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc triple-negative breast cancer misc biomarkers misc nanoparticles misc targeted therapy misc personalized therapy misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology
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title_sort	endorsement of tnbc biomarkers in precision therapy by nanotechnology
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title_auth	Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology
abstract	Breast cancer is a heterogeneous disease which accounts globally for approximately 1 million new cases annually, wherein more than 200,000 of these cases turn out to be cases of triple-negative breast cancer (TNBC). TNBC is an aggressive and rare breast cancer subtype that accounts for 10–15% of all breast cancer cases. Chemotherapy remains the only therapy regimen against TNBC. However, the emergence of innate or acquired chemoresistance has hindered the chemotherapy used to treat TNBC. The data obtained from molecular technologies have recognized TNBC with various gene profiling and mutation settings that have helped establish and develop targeted therapies. New therapeutic strategies based on the targeted delivery of therapeutics have relied on the application of biomarkers derived from the molecular profiling of TNBC patients. Several biomarkers have been found that are targets for the precision therapy in TNBC, such as EGFR, VGFR, TP53, interleukins, insulin-like growth factor binding proteins, c-MET, androgen receptor, BRCA1, glucocorticoid, PTEN, ALDH1, etc. This review discusses the various candidate biomarkers identified in the treatment of TNBC along with the evidence supporting their use. It was established that nanoparticles had been considered a multifunctional system for delivering therapeutics to target sites with increased precision. Here, we also discuss the role of biomarkers in nanotechnology translation in TNBC therapy and management.
abstractGer	Breast cancer is a heterogeneous disease which accounts globally for approximately 1 million new cases annually, wherein more than 200,000 of these cases turn out to be cases of triple-negative breast cancer (TNBC). TNBC is an aggressive and rare breast cancer subtype that accounts for 10–15% of all breast cancer cases. Chemotherapy remains the only therapy regimen against TNBC. However, the emergence of innate or acquired chemoresistance has hindered the chemotherapy used to treat TNBC. The data obtained from molecular technologies have recognized TNBC with various gene profiling and mutation settings that have helped establish and develop targeted therapies. New therapeutic strategies based on the targeted delivery of therapeutics have relied on the application of biomarkers derived from the molecular profiling of TNBC patients. Several biomarkers have been found that are targets for the precision therapy in TNBC, such as EGFR, VGFR, TP53, interleukins, insulin-like growth factor binding proteins, c-MET, androgen receptor, BRCA1, glucocorticoid, PTEN, ALDH1, etc. This review discusses the various candidate biomarkers identified in the treatment of TNBC along with the evidence supporting their use. It was established that nanoparticles had been considered a multifunctional system for delivering therapeutics to target sites with increased precision. Here, we also discuss the role of biomarkers in nanotechnology translation in TNBC therapy and management.
abstract_unstemmed	Breast cancer is a heterogeneous disease which accounts globally for approximately 1 million new cases annually, wherein more than 200,000 of these cases turn out to be cases of triple-negative breast cancer (TNBC). TNBC is an aggressive and rare breast cancer subtype that accounts for 10–15% of all breast cancer cases. Chemotherapy remains the only therapy regimen against TNBC. However, the emergence of innate or acquired chemoresistance has hindered the chemotherapy used to treat TNBC. The data obtained from molecular technologies have recognized TNBC with various gene profiling and mutation settings that have helped establish and develop targeted therapies. New therapeutic strategies based on the targeted delivery of therapeutics have relied on the application of biomarkers derived from the molecular profiling of TNBC patients. Several biomarkers have been found that are targets for the precision therapy in TNBC, such as EGFR, VGFR, TP53, interleukins, insulin-like growth factor binding proteins, c-MET, androgen receptor, BRCA1, glucocorticoid, PTEN, ALDH1, etc. This review discusses the various candidate biomarkers identified in the treatment of TNBC along with the evidence supporting their use. It was established that nanoparticles had been considered a multifunctional system for delivering therapeutics to target sites with increased precision. Here, we also discuss the role of biomarkers in nanotechnology translation in TNBC therapy and management.
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title_short	Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology
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Endorsement of TNBC Biomarkers in Precision Therapy by Nanotechnology

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