Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies

ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid ha...
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Autor*in:	Zarina Mushtaq [verfasserIn] Muhammad Imran [verfasserIn] Muzzamal Hussain [verfasserIn] Farhan Saeed [verfasserIn] Ali Imran [verfasserIn] Maryam Umar [verfasserIn] Mohamed A. Abdelgawad [verfasserIn] Ahmed H. El-Ghorab [verfasserIn] Awais Ahmed [verfasserIn] Suliman A. Alsagaby [verfasserIn] Mohamad Fawzi Mahomoodally [verfasserIn] Entessar Al Jbawi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Asiatic acid terpenoids polypharmacological properties anticancer antidiabetic cardioprotective

Übergeordnetes Werk:	In: International Journal of Food Properties - Taylor & Francis Group, 2018, 26(2023), 1, Seite 1244-1263
Übergeordnetes Werk:	volume:26 ; year:2023 ; number:1 ; pages:1244-1263

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/10942912.2023.2209702

Katalog-ID:	DOAJ090448278

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520			\|a ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics.
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spelling	10.1080/10942912.2023.2209702 doi (DE-627)DOAJ090448278 (DE-599)DOAJ1d37691938ff40adae778b1d398c01d1 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Zarina Mushtaq verfasserin aut Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics. Asiatic acid terpenoids polypharmacological properties anticancer antidiabetic cardioprotective Nutrition. Foods and food supply Food processing and manufacture Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Farhan Saeed verfasserin aut Ali Imran verfasserin aut Maryam Umar verfasserin aut Mohamed A. Abdelgawad verfasserin aut Ahmed H. El-Ghorab verfasserin aut Awais Ahmed verfasserin aut Suliman A. Alsagaby verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1244-1263 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1244-1263 https://doi.org/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/article/1d37691938ff40adae778b1d398c01d1 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1244-1263
allfields_unstemmed	10.1080/10942912.2023.2209702 doi (DE-627)DOAJ090448278 (DE-599)DOAJ1d37691938ff40adae778b1d398c01d1 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Zarina Mushtaq verfasserin aut Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics. Asiatic acid terpenoids polypharmacological properties anticancer antidiabetic cardioprotective Nutrition. Foods and food supply Food processing and manufacture Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Farhan Saeed verfasserin aut Ali Imran verfasserin aut Maryam Umar verfasserin aut Mohamed A. Abdelgawad verfasserin aut Ahmed H. El-Ghorab verfasserin aut Awais Ahmed verfasserin aut Suliman A. Alsagaby verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1244-1263 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1244-1263 https://doi.org/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/article/1d37691938ff40adae778b1d398c01d1 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1244-1263
allfieldsGer	10.1080/10942912.2023.2209702 doi (DE-627)DOAJ090448278 (DE-599)DOAJ1d37691938ff40adae778b1d398c01d1 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Zarina Mushtaq verfasserin aut Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics. Asiatic acid terpenoids polypharmacological properties anticancer antidiabetic cardioprotective Nutrition. Foods and food supply Food processing and manufacture Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Farhan Saeed verfasserin aut Ali Imran verfasserin aut Maryam Umar verfasserin aut Mohamed A. Abdelgawad verfasserin aut Ahmed H. El-Ghorab verfasserin aut Awais Ahmed verfasserin aut Suliman A. Alsagaby verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1244-1263 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1244-1263 https://doi.org/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/article/1d37691938ff40adae778b1d398c01d1 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1244-1263
allfieldsSound	10.1080/10942912.2023.2209702 doi (DE-627)DOAJ090448278 (DE-599)DOAJ1d37691938ff40adae778b1d398c01d1 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Zarina Mushtaq verfasserin aut Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics. Asiatic acid terpenoids polypharmacological properties anticancer antidiabetic cardioprotective Nutrition. Foods and food supply Food processing and manufacture Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Farhan Saeed verfasserin aut Ali Imran verfasserin aut Maryam Umar verfasserin aut Mohamed A. Abdelgawad verfasserin aut Ahmed H. El-Ghorab verfasserin aut Awais Ahmed verfasserin aut Suliman A. Alsagaby verfasserin aut Mohamad Fawzi Mahomoodally verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1244-1263 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1244-1263 https://doi.org/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/article/1d37691938ff40adae778b1d398c01d1 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2209702 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1244-1263
language	English
source	In International Journal of Food Properties 26(2023), 1, Seite 1244-1263 volume:26 year:2023 number:1 pages:1244-1263
sourceStr	In International Journal of Food Properties 26(2023), 1, Seite 1244-1263 volume:26 year:2023 number:1 pages:1244-1263
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Asiatic acid terpenoids polypharmacological properties anticancer antidiabetic cardioprotective Nutrition. Foods and food supply Food processing and manufacture
isfreeaccess_bool	true
container_title	International Journal of Food Properties
authorswithroles_txt_mv	Zarina Mushtaq @@aut@@ Muhammad Imran @@aut@@ Muzzamal Hussain @@aut@@ Farhan Saeed @@aut@@ Ali Imran @@aut@@ Maryam Umar @@aut@@ Mohamed A. Abdelgawad @@aut@@ Ahmed H. El-Ghorab @@aut@@ Awais Ahmed @@aut@@ Suliman A. Alsagaby @@aut@@ Mohamad Fawzi Mahomoodally @@aut@@ Entessar Al Jbawi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	334376416
id	DOAJ090448278
language_de	englisch
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author	Zarina Mushtaq
spellingShingle	Zarina Mushtaq misc TX341-641 misc TP368-456 misc Asiatic acid misc terpenoids misc polypharmacological properties misc anticancer misc antidiabetic misc cardioprotective misc Nutrition. Foods and food supply misc Food processing and manufacture Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies
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title	Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies
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author_browse	Zarina Mushtaq Muhammad Imran Muzzamal Hussain Farhan Saeed Ali Imran Maryam Umar Mohamed A. Abdelgawad Ahmed H. El-Ghorab Awais Ahmed Suliman A. Alsagaby Mohamad Fawzi Mahomoodally Entessar Al Jbawi
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title_sort	asiatic acid: a review on its polypharmacological properties and therapeutic potential against various maladies
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title_auth	Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies
abstract	ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics.
abstractGer	ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics.
abstract_unstemmed	ABSTRACTAsiatic acid (AA) is a natural aglycone of pentacyclic triterpenoids and is abundantly present in many edible and medicinal plants, including Centella Asiatica, which is a reputed herb for wound healing and neuropsychiatric disorders in many traditional medicine formulations. Asiatic acid has various pharmacological functions such as antioxidant and anti-inflammatory and controls apoptosis, which in numerous diseases credits to its medicinal impact. In preclinical trials, asiatic acid demonstrated potent antihypertensive, neuroprotective, cardioprotective, antidiabetic, antimicrobial, and antitumor behaviors. It has been shown to influence multiple enzymes, receptors, growth factors, transcription factors, apoptotic proteins, and cell signaling cascades in several in vitro and in vivo experiments. This review aims to reflect the current therapeutic potential reports and the underlying pharmacological and molecular mechanisms of asiatic acid. In various diseases, studies display Asiatic acid’s polypharmacological properties, therapeutic ability, and molecular pathways. With the available research data, asiatic acid appears to be a significant multi-targeted, natural-origin polypharmacological agent for further pharmaceutical production and clinical use. Provided advantageous pharmacokinetics, protection, and effectiveness, along with commonly used modern drugs. Asiatic acid may be a potential agent or adjuvant, with a pharmacological justification for its usage in therapeutics.
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title_short	Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies
url	https://doi.org/10.1080/10942912.2023.2209702 https://doaj.org/article/1d37691938ff40adae778b1d398c01d1 https://www.tandfonline.com/doi/10.1080/10942912.2023.2209702 https://doaj.org/toc/1094-2912 https://doaj.org/toc/1532-2386
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author2	Muhammad Imran Muzzamal Hussain Farhan Saeed Ali Imran Maryam Umar Mohamed A. Abdelgawad Ahmed H. El-Ghorab Awais Ahmed Suliman A. Alsagaby Mohamad Fawzi Mahomoodally Entessar Al Jbawi
author2Str	Muhammad Imran Muzzamal Hussain Farhan Saeed Ali Imran Maryam Umar Mohamed A. Abdelgawad Ahmed H. El-Ghorab Awais Ahmed Suliman A. Alsagaby Mohamad Fawzi Mahomoodally Entessar Al Jbawi
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Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies

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