Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus

Carnation is edible flower that has potent antioxidant properties and is used in traditional Chinese medicinal system and food industry. The phytochemicals responsible for these various proprieties, however, are not fully understood. Thus, in order to recognize metabolite diversity and variability i...
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Gespeichert in:

Autor*in:	Xuhong Zhou [verfasserIn] Miaomaio Wang [verfasserIn] Hong Li [verfasserIn] Shilong Ye [verfasserIn] Wenru Tang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	carnation flowers edible flower flower color phytochemical composition biological activity

Übergeordnetes Werk:	In: Frontiers in Nutrition - Frontiers Media S.A., 2014, 10(2023)
Übergeordnetes Werk:	volume:10 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnut.2023.1166375

Katalog-ID:	DOAJ090575393

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callnumber-first	T - Technology
author	Xuhong Zhou
spellingShingle	Xuhong Zhou misc TX341-641 misc carnation flowers misc edible flower misc flower color misc phytochemical composition misc biological activity misc Nutrition. Foods and food supply Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus
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topic_title	TX341-641 Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus carnation flowers edible flower flower color phytochemical composition biological activity
topic	misc TX341-641 misc carnation flowers misc edible flower misc flower color misc phytochemical composition misc biological activity misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc carnation flowers misc edible flower misc flower color misc phytochemical composition misc biological activity misc Nutrition. Foods and food supply
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title	Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus
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title_full	Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus
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title_sort	widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of dianthus caryophyllus
callnumber	TX341-641
title_auth	Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus
abstract	Carnation is edible flower that has potent antioxidant properties and is used in traditional Chinese medicinal system and food industry. The phytochemicals responsible for these various proprieties, however, are not fully understood. Thus, in order to recognize metabolite diversity and variability in carnation flowers of different colors and to discover key metabolites that contribute to the differences in antioxidant and anticancer activities, widely targeted LC-MS/MS-based metabolomics analysis was conducted on purple, green, yellow, and white carnation flowers. We identified and chemically categorized 932 metabolites. Metabolic compounds varied significantly with flower color. Several flavonoids, organic acids, phenolic acids, and nucleotides and their derivatives were found to be specific differential metabolites in purple flowers. A total of 128 key differential metabolites were screened. The purple flowers were found to have the highest antioxidant and anticancer activities compared to the other colored flowers. Correlation analysis revealed that the 6-hydroxykaempferol-3,6-O-diglucoside, 6-hydroxykaempferol-7-O-glucoside, quercetin-3-O-sophoroside, and 2′-deoxyguanosine were found to be the major constituents of the antioxidant and anticancer activities. 2′-Deoxyguanosine has effective antiproliferative activity against A549 and U2OS cells for the first report. At the same time, the combination of 2′-deoxyguanosine with 6-hydroxykaempferol-3, 6-O-diglucoside, or quercetin-3-O-sophoroside have also been found to increase the antitumor activity of 2′-deoxyguanosine. These discoveries enrich information on the phytochemical composition of carnation of different colors and provide resources for the overall use and improvement of carnation flowers quality.
abstractGer	Carnation is edible flower that has potent antioxidant properties and is used in traditional Chinese medicinal system and food industry. The phytochemicals responsible for these various proprieties, however, are not fully understood. Thus, in order to recognize metabolite diversity and variability in carnation flowers of different colors and to discover key metabolites that contribute to the differences in antioxidant and anticancer activities, widely targeted LC-MS/MS-based metabolomics analysis was conducted on purple, green, yellow, and white carnation flowers. We identified and chemically categorized 932 metabolites. Metabolic compounds varied significantly with flower color. Several flavonoids, organic acids, phenolic acids, and nucleotides and their derivatives were found to be specific differential metabolites in purple flowers. A total of 128 key differential metabolites were screened. The purple flowers were found to have the highest antioxidant and anticancer activities compared to the other colored flowers. Correlation analysis revealed that the 6-hydroxykaempferol-3,6-O-diglucoside, 6-hydroxykaempferol-7-O-glucoside, quercetin-3-O-sophoroside, and 2′-deoxyguanosine were found to be the major constituents of the antioxidant and anticancer activities. 2′-Deoxyguanosine has effective antiproliferative activity against A549 and U2OS cells for the first report. At the same time, the combination of 2′-deoxyguanosine with 6-hydroxykaempferol-3, 6-O-diglucoside, or quercetin-3-O-sophoroside have also been found to increase the antitumor activity of 2′-deoxyguanosine. These discoveries enrich information on the phytochemical composition of carnation of different colors and provide resources for the overall use and improvement of carnation flowers quality.
abstract_unstemmed	Carnation is edible flower that has potent antioxidant properties and is used in traditional Chinese medicinal system and food industry. The phytochemicals responsible for these various proprieties, however, are not fully understood. Thus, in order to recognize metabolite diversity and variability in carnation flowers of different colors and to discover key metabolites that contribute to the differences in antioxidant and anticancer activities, widely targeted LC-MS/MS-based metabolomics analysis was conducted on purple, green, yellow, and white carnation flowers. We identified and chemically categorized 932 metabolites. Metabolic compounds varied significantly with flower color. Several flavonoids, organic acids, phenolic acids, and nucleotides and their derivatives were found to be specific differential metabolites in purple flowers. A total of 128 key differential metabolites were screened. The purple flowers were found to have the highest antioxidant and anticancer activities compared to the other colored flowers. Correlation analysis revealed that the 6-hydroxykaempferol-3,6-O-diglucoside, 6-hydroxykaempferol-7-O-glucoside, quercetin-3-O-sophoroside, and 2′-deoxyguanosine were found to be the major constituents of the antioxidant and anticancer activities. 2′-Deoxyguanosine has effective antiproliferative activity against A549 and U2OS cells for the first report. At the same time, the combination of 2′-deoxyguanosine with 6-hydroxykaempferol-3, 6-O-diglucoside, or quercetin-3-O-sophoroside have also been found to increase the antitumor activity of 2′-deoxyguanosine. These discoveries enrich information on the phytochemical composition of carnation of different colors and provide resources for the overall use and improvement of carnation flowers quality.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700
title_short	Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus
url	https://doi.org/10.3389/fnut.2023.1166375 https://doaj.org/article/916abb333f96419d8d2b6b02505f66b7 https://www.frontiersin.org/articles/10.3389/fnut.2023.1166375/full https://doaj.org/toc/2296-861X
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Widely targeted metabolomics reveals the antioxidant and anticancer activities of different colors of Dianthus caryophyllus

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