Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy

IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures...
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Autor*in:	Justyna Chałubińska-Fendler [verfasserIn] Zuzanna Nowicka [verfasserIn] Izabela Dróżdż [verfasserIn] Łukasz Graczyk [verfasserIn] Grzegorz Piotrowski [verfasserIn] Bartłomiej Tomasik [verfasserIn] Michał Spych [verfasserIn] Jacek Fijuth [verfasserIn] Anna Papis-Ubych [verfasserIn] Piotr Kędzierawski [verfasserIn] David Kozono [verfasserIn] Wojciech Fendler [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 13(2023)
Übergeordnetes Werk:	volume:13 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2023.1150979

Katalog-ID:	DOAJ090592786

Internformat


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520			\|a IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints.
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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allfields	10.3389/fonc.2023.1150979 doi (DE-627)DOAJ090592786 (DE-599)DOAJff717de668fb4b3aa89441df1fa2e9f8 DE-627 ger DE-627 rakwb eng RC254-282 Justyna Chałubińska-Fendler verfasserin aut Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints. breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zuzanna Nowicka verfasserin aut Izabela Dróżdż verfasserin aut Łukasz Graczyk verfasserin aut Łukasz Graczyk verfasserin aut Grzegorz Piotrowski verfasserin aut Grzegorz Piotrowski verfasserin aut Bartłomiej Tomasik verfasserin aut Bartłomiej Tomasik verfasserin aut Michał Spych verfasserin aut Jacek Fijuth verfasserin aut Jacek Fijuth verfasserin aut Anna Papis-Ubych verfasserin aut Piotr Kędzierawski verfasserin aut David Kozono verfasserin aut Wojciech Fendler verfasserin aut Wojciech Fendler verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 13(2023) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:13 year:2023 https://doi.org/10.3389/fonc.2023.1150979 kostenfrei https://doaj.org/article/ff717de668fb4b3aa89441df1fa2e9f8 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2023.1150979/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
spelling	10.3389/fonc.2023.1150979 doi (DE-627)DOAJ090592786 (DE-599)DOAJff717de668fb4b3aa89441df1fa2e9f8 DE-627 ger DE-627 rakwb eng RC254-282 Justyna Chałubińska-Fendler verfasserin aut Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints. breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zuzanna Nowicka verfasserin aut Izabela Dróżdż verfasserin aut Łukasz Graczyk verfasserin aut Łukasz Graczyk verfasserin aut Grzegorz Piotrowski verfasserin aut Grzegorz Piotrowski verfasserin aut Bartłomiej Tomasik verfasserin aut Bartłomiej Tomasik verfasserin aut Michał Spych verfasserin aut Jacek Fijuth verfasserin aut Jacek Fijuth verfasserin aut Anna Papis-Ubych verfasserin aut Piotr Kędzierawski verfasserin aut David Kozono verfasserin aut Wojciech Fendler verfasserin aut Wojciech Fendler verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 13(2023) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:13 year:2023 https://doi.org/10.3389/fonc.2023.1150979 kostenfrei https://doaj.org/article/ff717de668fb4b3aa89441df1fa2e9f8 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2023.1150979/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
allfields_unstemmed	10.3389/fonc.2023.1150979 doi (DE-627)DOAJ090592786 (DE-599)DOAJff717de668fb4b3aa89441df1fa2e9f8 DE-627 ger DE-627 rakwb eng RC254-282 Justyna Chałubińska-Fendler verfasserin aut Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints. breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zuzanna Nowicka verfasserin aut Izabela Dróżdż verfasserin aut Łukasz Graczyk verfasserin aut Łukasz Graczyk verfasserin aut Grzegorz Piotrowski verfasserin aut Grzegorz Piotrowski verfasserin aut Bartłomiej Tomasik verfasserin aut Bartłomiej Tomasik verfasserin aut Michał Spych verfasserin aut Jacek Fijuth verfasserin aut Jacek Fijuth verfasserin aut Anna Papis-Ubych verfasserin aut Piotr Kędzierawski verfasserin aut David Kozono verfasserin aut Wojciech Fendler verfasserin aut Wojciech Fendler verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 13(2023) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:13 year:2023 https://doi.org/10.3389/fonc.2023.1150979 kostenfrei https://doaj.org/article/ff717de668fb4b3aa89441df1fa2e9f8 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2023.1150979/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
allfieldsGer	10.3389/fonc.2023.1150979 doi (DE-627)DOAJ090592786 (DE-599)DOAJff717de668fb4b3aa89441df1fa2e9f8 DE-627 ger DE-627 rakwb eng RC254-282 Justyna Chałubińska-Fendler verfasserin aut Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints. breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zuzanna Nowicka verfasserin aut Izabela Dróżdż verfasserin aut Łukasz Graczyk verfasserin aut Łukasz Graczyk verfasserin aut Grzegorz Piotrowski verfasserin aut Grzegorz Piotrowski verfasserin aut Bartłomiej Tomasik verfasserin aut Bartłomiej Tomasik verfasserin aut Michał Spych verfasserin aut Jacek Fijuth verfasserin aut Jacek Fijuth verfasserin aut Anna Papis-Ubych verfasserin aut Piotr Kędzierawski verfasserin aut David Kozono verfasserin aut Wojciech Fendler verfasserin aut Wojciech Fendler verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 13(2023) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:13 year:2023 https://doi.org/10.3389/fonc.2023.1150979 kostenfrei https://doaj.org/article/ff717de668fb4b3aa89441df1fa2e9f8 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2023.1150979/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
allfieldsSound	10.3389/fonc.2023.1150979 doi (DE-627)DOAJ090592786 (DE-599)DOAJff717de668fb4b3aa89441df1fa2e9f8 DE-627 ger DE-627 rakwb eng RC254-282 Justyna Chałubińska-Fendler verfasserin aut Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints. breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens Zuzanna Nowicka verfasserin aut Izabela Dróżdż verfasserin aut Łukasz Graczyk verfasserin aut Łukasz Graczyk verfasserin aut Grzegorz Piotrowski verfasserin aut Grzegorz Piotrowski verfasserin aut Bartłomiej Tomasik verfasserin aut Bartłomiej Tomasik verfasserin aut Michał Spych verfasserin aut Jacek Fijuth verfasserin aut Jacek Fijuth verfasserin aut Anna Papis-Ubych verfasserin aut Piotr Kędzierawski verfasserin aut David Kozono verfasserin aut Wojciech Fendler verfasserin aut Wojciech Fendler verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 13(2023) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:13 year:2023 https://doi.org/10.3389/fonc.2023.1150979 kostenfrei https://doaj.org/article/ff717de668fb4b3aa89441df1fa2e9f8 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2023.1150979/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023
language	English
source	In Frontiers in Oncology 13(2023) volume:13 year:2023
sourceStr	In Frontiers in Oncology 13(2023) volume:13 year:2023
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Frontiers in Oncology
authorswithroles_txt_mv	Justyna Chałubińska-Fendler @@aut@@ Zuzanna Nowicka @@aut@@ Izabela Dróżdż @@aut@@ Łukasz Graczyk @@aut@@ Grzegorz Piotrowski @@aut@@ Bartłomiej Tomasik @@aut@@ Michał Spych @@aut@@ Jacek Fijuth @@aut@@ Anna Papis-Ubych @@aut@@ Piotr Kędzierawski @@aut@@ David Kozono @@aut@@ Wojciech Fendler @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	684965518
id	DOAJ090592786
language_de	englisch
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callnumber-first	R - Medicine
author	Justyna Chałubińska-Fendler
spellingShingle	Justyna Chałubińska-Fendler misc RC254-282 misc breast cancer misc radiation-induced cardiac toxicity misc echocardiography misc biomarkers misc microRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy
authorStr	Justyna Chałubińska-Fendler
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topic_title	RC254-282 Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy breast cancer radiation-induced cardiac toxicity echocardiography biomarkers microRNA
topic	misc RC254-282 misc breast cancer misc radiation-induced cardiac toxicity misc echocardiography misc biomarkers misc microRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc breast cancer misc radiation-induced cardiac toxicity misc echocardiography misc biomarkers misc microRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc breast cancer misc radiation-induced cardiac toxicity misc echocardiography misc biomarkers misc microRNA misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy
ctrlnum	(DE-627)DOAJ090592786 (DE-599)DOAJff717de668fb4b3aa89441df1fa2e9f8
title_full	Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy
author_sort	Justyna Chałubińska-Fendler
journal	Frontiers in Oncology
journalStr	Frontiers in Oncology
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author_browse	Justyna Chałubińska-Fendler Zuzanna Nowicka Izabela Dróżdż Łukasz Graczyk Grzegorz Piotrowski Bartłomiej Tomasik Michał Spych Jacek Fijuth Anna Papis-Ubych Piotr Kędzierawski David Kozono Wojciech Fendler
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class	RC254-282
format_se	Elektronische Aufsätze
author-letter	Justyna Chałubińska-Fendler
doi_str_mv	10.3389/fonc.2023.1150979
author2-role	verfasserin
title_sort	radiation-induced circulating micrornas linked to echocardiography parameters after radiotherapy
callnumber	RC254-282
title_auth	Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy
abstract	IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints.
abstractGer	IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints.
abstract_unstemmed	IntroductionPatients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.Materials and methodsTwo parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before RT, 24h after the last dose and 1 month after RT; cardiac echocardiography was performed 2.5-3 year after RT.ResultsSeven miRNAs in the primary group showed marked changes in serum miRNAs immediately after RT compared to baseline and associations with cardiopulmonary dose-volume histogram metrics. Among those miRNAs: miR-15b-5p, miR-22-3p, miR-424-5p and miR-451a were confirmed to show significant decrease of expression 24 hours post-RT in the validation cohort. Moreover, miR-29c, miR-451 and miR-424 were correlated with the end-diastolic diameter of the left ventricle, which was also confirmed in multivariable analysis adjusting for RT-associated factors.ConclusionWe identified a subset of circulating miRNAs predictive for cardiac function impairment in patients treated for left-sided breast cancer, although longer clinical observation could determine if these can be used to predict major clinical endpoints.
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title_short	Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy
url	https://doi.org/10.3389/fonc.2023.1150979 https://doaj.org/article/ff717de668fb4b3aa89441df1fa2e9f8 https://www.frontiersin.org/articles/10.3389/fonc.2023.1150979/full https://doaj.org/toc/2234-943X
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author2	Zuzanna Nowicka Izabela Dróżdż Łukasz Graczyk Grzegorz Piotrowski Bartłomiej Tomasik Michał Spych Jacek Fijuth Anna Papis-Ubych Piotr Kędzierawski David Kozono Wojciech Fendler
author2Str	Zuzanna Nowicka Izabela Dróżdż Łukasz Graczyk Grzegorz Piotrowski Bartłomiej Tomasik Michał Spych Jacek Fijuth Anna Papis-Ubych Piotr Kędzierawski David Kozono Wojciech Fendler
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doi_str	10.3389/fonc.2023.1150979
callnumber-a	RC254-282
up_date	2024-07-03T15:40:39.340Z
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