Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells

T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last f...
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Gespeichert in:

Autor*in:	Edgar Angelats [verfasserIn] Pere Santamaria [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	autoimmunity T-regulatory (Treg) cells T-regulatory type 1 (TR1) cells peptide-MHC nanomedicine T-follicular helper cells (Tfh)

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2023.1267697

Katalog-ID:	DOAJ090741781

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520			\|a T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.
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spelling	10.3389/fimmu.2023.1267697 doi (DE-627)DOAJ090741781 (DE-599)DOAJ2efc782ff9904353b7c69e07ff36d616 DE-627 ger DE-627 rakwb eng RC581-607 Edgar Angelats verfasserin aut Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny. autoimmunity T-regulatory (Treg) cells T-regulatory type 1 (TR1) cells peptide-MHC nanomedicine T-follicular helper cells (Tfh) Immunologic diseases. Allergy Pere Santamaria verfasserin aut Pere Santamaria verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1267697 kostenfrei https://doaj.org/article/2efc782ff9904353b7c69e07ff36d616 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267697/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
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allfieldsSound	10.3389/fimmu.2023.1267697 doi (DE-627)DOAJ090741781 (DE-599)DOAJ2efc782ff9904353b7c69e07ff36d616 DE-627 ger DE-627 rakwb eng RC581-607 Edgar Angelats verfasserin aut Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny. autoimmunity T-regulatory (Treg) cells T-regulatory type 1 (TR1) cells peptide-MHC nanomedicine T-follicular helper cells (Tfh) Immunologic diseases. Allergy Pere Santamaria verfasserin aut Pere Santamaria verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1267697 kostenfrei https://doaj.org/article/2efc782ff9904353b7c69e07ff36d616 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1267697/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
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callnumber-first	R - Medicine
author	Edgar Angelats
spellingShingle	Edgar Angelats misc RC581-607 misc autoimmunity misc T-regulatory (Treg) cells misc T-regulatory type 1 (TR1) cells misc peptide-MHC misc nanomedicine misc T-follicular helper cells (Tfh) misc Immunologic diseases. Allergy Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
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topic_title	RC581-607 Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells autoimmunity T-regulatory (Treg) cells T-regulatory type 1 (TR1) cells peptide-MHC nanomedicine T-follicular helper cells (Tfh)
topic	misc RC581-607 misc autoimmunity misc T-regulatory (Treg) cells misc T-regulatory type 1 (TR1) cells misc peptide-MHC misc nanomedicine misc T-follicular helper cells (Tfh) misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc autoimmunity misc T-regulatory (Treg) cells misc T-regulatory type 1 (TR1) cells misc peptide-MHC misc nanomedicine misc T-follicular helper cells (Tfh) misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc autoimmunity misc T-regulatory (Treg) cells misc T-regulatory type 1 (TR1) cells misc peptide-MHC misc nanomedicine misc T-follicular helper cells (Tfh) misc Immunologic diseases. Allergy
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title	Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
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title_full	Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
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title_sort	lineage origin and transcriptional control of autoantigen-specific t-regulatory type 1 cells
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title_auth	Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
abstract	T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.
abstractGer	T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.
abstract_unstemmed	T Regulatory type-1 (TR1) cells represent an immunosuppressive T cell subset, discovered over 25 years ago, that produces high levels of interleukin-10 (IL-10) but, unlike its FoxP3+ T regulatory (Treg) cell counterpart, does not express FoxP3 or CD25. Experimental evidence generated over the last few years has exposed a promising role for TR1 cells as targets of therapeutic intervention in immune-mediated diseases. The discovery of cell surface markers capable of distinguishing these cells from related T cell types and the application of next generation sequencing techniques to defining their transcriptional make-up have enabled a more accurate description of this T cell population. However, the developmental biology of TR1 cells has long remained elusive, in particular the identity of the cell type(s) giving rise to bona fide TR1 cells in vivo. Here, we review the fundamental phenotypic, transcriptional and functional properties of this T cell subset, and summarize recent lines of evidence shedding light into its ontogeny.
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title_short	Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells
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Lineage origin and transcriptional control of autoantigen-specific T-regulatory type 1 cells

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