Microbial-host-isozyme: unveiling a new era in microbiome–host interaction
ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bac...
Ausführliche Beschreibung
Autor*in: |
Lei Miao [verfasserIn] Herbert Tilg [verfasserIn] Ming-Hua Zheng [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Übergeordnetes Werk: |
In: Gut Microbes - Taylor & Francis Group, 2020, 15(2023), 2 |
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Übergeordnetes Werk: |
volume:15 ; year:2023 ; number:2 |
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Link aufrufen |
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DOI / URN: |
10.1080/19490976.2023.2267185 |
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Katalog-ID: |
DOAJ09083948X |
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10.1080/19490976.2023.2267185 doi (DE-627)DOAJ09083948X (DE-599)DOAJ16073f59495e4ecb8917f1208b210257 DE-627 ger DE-627 rakwb eng RC799-869 Lei Miao verfasserin aut Microbial-host-isozyme: unveiling a new era in microbiome–host interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. Microbial-Host isozymes metabolic diseases Diseases of the digestive system. Gastroenterology Herbert Tilg verfasserin aut Ming-Hua Zheng verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 15(2023), 2 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:15 year:2023 number:2 https://doi.org/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/article/16073f59495e4ecb8917f1208b210257 kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 2 |
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10.1080/19490976.2023.2267185 doi (DE-627)DOAJ09083948X (DE-599)DOAJ16073f59495e4ecb8917f1208b210257 DE-627 ger DE-627 rakwb eng RC799-869 Lei Miao verfasserin aut Microbial-host-isozyme: unveiling a new era in microbiome–host interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. Microbial-Host isozymes metabolic diseases Diseases of the digestive system. Gastroenterology Herbert Tilg verfasserin aut Ming-Hua Zheng verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 15(2023), 2 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:15 year:2023 number:2 https://doi.org/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/article/16073f59495e4ecb8917f1208b210257 kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 2 |
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10.1080/19490976.2023.2267185 doi (DE-627)DOAJ09083948X (DE-599)DOAJ16073f59495e4ecb8917f1208b210257 DE-627 ger DE-627 rakwb eng RC799-869 Lei Miao verfasserin aut Microbial-host-isozyme: unveiling a new era in microbiome–host interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. Microbial-Host isozymes metabolic diseases Diseases of the digestive system. Gastroenterology Herbert Tilg verfasserin aut Ming-Hua Zheng verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 15(2023), 2 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:15 year:2023 number:2 https://doi.org/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/article/16073f59495e4ecb8917f1208b210257 kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 2 |
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10.1080/19490976.2023.2267185 doi (DE-627)DOAJ09083948X (DE-599)DOAJ16073f59495e4ecb8917f1208b210257 DE-627 ger DE-627 rakwb eng RC799-869 Lei Miao verfasserin aut Microbial-host-isozyme: unveiling a new era in microbiome–host interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. Microbial-Host isozymes metabolic diseases Diseases of the digestive system. Gastroenterology Herbert Tilg verfasserin aut Ming-Hua Zheng verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 15(2023), 2 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:15 year:2023 number:2 https://doi.org/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/article/16073f59495e4ecb8917f1208b210257 kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 2 |
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10.1080/19490976.2023.2267185 doi (DE-627)DOAJ09083948X (DE-599)DOAJ16073f59495e4ecb8917f1208b210257 DE-627 ger DE-627 rakwb eng RC799-869 Lei Miao verfasserin aut Microbial-host-isozyme: unveiling a new era in microbiome–host interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. Microbial-Host isozymes metabolic diseases Diseases of the digestive system. Gastroenterology Herbert Tilg verfasserin aut Ming-Hua Zheng verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 15(2023), 2 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:15 year:2023 number:2 https://doi.org/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/article/16073f59495e4ecb8917f1208b210257 kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2023.2267185 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 2 |
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ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. |
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ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. |
abstract_unstemmed |
ABSTRACTWang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota–host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens new avenues for metabolic disorder treatment. However, the complex nature of gut symbiotic bacteria requires further research to understand MHI mechanisms, regulatory roles, and interactions with the host. Precise interventions in gut microbiota offer personalized approaches to metabolic diseases. |
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