Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus

Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Du J [verfasserIn] Zhao X [verfasserIn] Xu X [verfasserIn] Zhang Z [verfasserIn] Zhang X [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis.

Übergeordnetes Werk:	In: Diabetes, Metabolic Syndrome and Obesity - Dove Medical Press, 2009, (2023), Seite 3163-3171
Übergeordnetes Werk:	year:2023 ; pages:3163-3171

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ090934911

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520			\|a Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis
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allfields	(DE-627)DOAJ090934911 (DE-599)DOAJ378d887283724959a34510812d7dc091 DE-627 ger DE-627 rakwb eng RC581-951 Du J verfasserin aut Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis. Specialties of internal medicine Zhao X verfasserin aut Xu X verfasserin aut Zhang Z verfasserin aut Zhang X verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 3163-3171 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:3163-3171 https://doaj.org/article/378d887283724959a34510812d7dc091 kostenfrei https://www.dovepress.com/association-between-thyroid-parameters-and-subclinical-atherosclerosis-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 3163-3171
spelling	(DE-627)DOAJ090934911 (DE-599)DOAJ378d887283724959a34510812d7dc091 DE-627 ger DE-627 rakwb eng RC581-951 Du J verfasserin aut Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis. Specialties of internal medicine Zhao X verfasserin aut Xu X verfasserin aut Zhang Z verfasserin aut Zhang X verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 3163-3171 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:3163-3171 https://doaj.org/article/378d887283724959a34510812d7dc091 kostenfrei https://www.dovepress.com/association-between-thyroid-parameters-and-subclinical-atherosclerosis-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 3163-3171
allfields_unstemmed	(DE-627)DOAJ090934911 (DE-599)DOAJ378d887283724959a34510812d7dc091 DE-627 ger DE-627 rakwb eng RC581-951 Du J verfasserin aut Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis. Specialties of internal medicine Zhao X verfasserin aut Xu X verfasserin aut Zhang Z verfasserin aut Zhang X verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 3163-3171 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:3163-3171 https://doaj.org/article/378d887283724959a34510812d7dc091 kostenfrei https://www.dovepress.com/association-between-thyroid-parameters-and-subclinical-atherosclerosis-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 3163-3171
allfieldsGer	(DE-627)DOAJ090934911 (DE-599)DOAJ378d887283724959a34510812d7dc091 DE-627 ger DE-627 rakwb eng RC581-951 Du J verfasserin aut Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis. Specialties of internal medicine Zhao X verfasserin aut Xu X verfasserin aut Zhang Z verfasserin aut Zhang X verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 3163-3171 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:3163-3171 https://doaj.org/article/378d887283724959a34510812d7dc091 kostenfrei https://www.dovepress.com/association-between-thyroid-parameters-and-subclinical-atherosclerosis-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 3163-3171
allfieldsSound	(DE-627)DOAJ090934911 (DE-599)DOAJ378d887283724959a34510812d7dc091 DE-627 ger DE-627 rakwb eng RC581-951 Du J verfasserin aut Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis. Specialties of internal medicine Zhao X verfasserin aut Xu X verfasserin aut Zhang Z verfasserin aut Zhang X verfasserin aut In Diabetes, Metabolic Syndrome and Obesity Dove Medical Press, 2009 (2023), Seite 3163-3171 (DE-627)60030597X (DE-600)2494854-8 11787007 nnns year:2023 pages:3163-3171 https://doaj.org/article/378d887283724959a34510812d7dc091 kostenfrei https://www.dovepress.com/association-between-thyroid-parameters-and-subclinical-atherosclerosis-peer-reviewed-fulltext-article-DMSO kostenfrei https://doaj.org/toc/1178-7007 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 3163-3171
language	English
source	In Diabetes, Metabolic Syndrome and Obesity (2023), Seite 3163-3171 year:2023 pages:3163-3171
sourceStr	In Diabetes, Metabolic Syndrome and Obesity (2023), Seite 3163-3171 year:2023 pages:3163-3171
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis. Specialties of internal medicine
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container_title	Diabetes, Metabolic Syndrome and Obesity
authorswithroles_txt_mv	Du J @@aut@@ Zhao X @@aut@@ Xu X @@aut@@ Zhang Z @@aut@@ Zhang X @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ090934911</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412230043.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240412s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ090934911</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ378d887283724959a34510812d7dc091</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC581-951</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Du J</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. 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callnumber-first	R - Medicine
author	Du J
spellingShingle	Du J misc RC581-951 misc thyroid hormone misc thyroid hormone sensitivity misc euthyroid misc diabetes mellitus misc atherosclerosis. misc Specialties of internal medicine Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus
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topic_title	RC581-951 Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus thyroid hormone thyroid hormone sensitivity euthyroid diabetes mellitus atherosclerosis
topic	misc RC581-951 misc thyroid hormone misc thyroid hormone sensitivity misc euthyroid misc diabetes mellitus misc atherosclerosis. misc Specialties of internal medicine
topic_unstemmed	misc RC581-951 misc thyroid hormone misc thyroid hormone sensitivity misc euthyroid misc diabetes mellitus misc atherosclerosis. misc Specialties of internal medicine
topic_browse	misc RC581-951 misc thyroid hormone misc thyroid hormone sensitivity misc euthyroid misc diabetes mellitus misc atherosclerosis. misc Specialties of internal medicine
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title	Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus
ctrlnum	(DE-627)DOAJ090934911 (DE-599)DOAJ378d887283724959a34510812d7dc091
title_full	Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus
author_sort	Du J
journal	Diabetes, Metabolic Syndrome and Obesity
journalStr	Diabetes, Metabolic Syndrome and Obesity
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author_browse	Du J Zhao X Xu X Zhang Z Zhang X
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author-letter	Du J
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title_sort	association between thyroid parameters and subclinical atherosclerosis in hospitalised euthyroid patients with type 2 diabetes mellitus
callnumber	RC581-951
title_auth	Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus
abstract	Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis
abstractGer	Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis
abstract_unstemmed	Jing Du, Xin Zhao, Xiumei Xu, Zhichao Zhang, Xiaomei Zhang Department of Endocrinology and Metabolism, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaomei Zhang, Department of Endocrinology and metabolism, Peking University International Hospital, No. 1 Life Garden Road Zhongguancun Life Science Garden Changping District, Beijing, People’s Republic of China, Tel/Fax +86-010-69006105, Email z.x.mei163.comPurpose: To explore the association between thyroid parameters and subclinical atherosclerosis (AS) in hospitalised euthyroid patients with type 2 diabetes mellitus (T2DM).Patients and Methods: A retrospective analysis was conducted involving 1245 inpatients with T2DM. Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). FT3/FT4 demonstrated superior predictive accuracy for subclinical AS than that of FT3 or FT4 alone (P < 0.001), with a cutoff point of 0.25.Conclusion: In euthyroid inpatients with T2DM, subclinical AS exhibited negative correlation with FT3, FT4, and FT3/FT4 levels, independent of other risk factors for AS. Additionally, FT3/FT4 ratio had a good predictive value for subclinical AS.Keywords: thyroid hormone, thyroid hormone sensitivity, euthyroid, diabetes mellitus, atherosclerosis
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title_short	Association Between Thyroid Parameters and Subclinical Atherosclerosis in Hospitalised Euthyroid Patients with Type 2 Diabetes Mellitus
url	https://doaj.org/article/378d887283724959a34510812d7dc091 https://www.dovepress.com/association-between-thyroid-parameters-and-subclinical-atherosclerosis-peer-reviewed-fulltext-article-DMSO https://doaj.org/toc/1178-7007
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author2	Zhao X Xu X Zhang Z Zhang X
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up_date	2024-07-03T17:28:32.704Z
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Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) levels were measured, and carotid artery ultrasonography was performed. Thyroid hormone (TH) sensitivity was evaluated using thyroid feedback quantile-based index (TFQI), TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), and free triiodothyronine/free thyroxine ratio (FT3/FT4).Results: In inpatients with T2DM having normal thyroid function, the incidence of subclinical AS declined with increasing levels of FT3, FT4, and FT3/FT4 (P trend < 0.05). Logistic regression analysis revealed that FT4 (OR, 0.914; 95% CI, 0.845– 0.989), FT3 (OR, 0.374; 95% CI, 0.277– 0.504), and FT3/FT4 (OR, 0.036; 95% CI, 0.013– 0.061) were independently associated with subclinical AS (P < 0.05). However, TSH, TFQI, TSHI, and TT4RI levels were not associated with subclinical AS (P < 0.05). 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