Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial
Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroarte...
Ausführliche Beschreibung
Autor*in: |
Esperanca Sevene [verfasserIn] Anifa Vala [verfasserIn] Salésio Macuacua [verfasserIn] Kassoum Kayentao [verfasserIn] Issaka Sagara [verfasserIn] Halidou Tinto [verfasserIn] Clara Menendez [verfasserIn] Raquel González [verfasserIn] Umberto d'Alessandro [verfasserIn] Hamadoun Diakite [verfasserIn] Moussa Djimde [verfasserIn] Hypolite Mavoko Muhindo [verfasserIn] Mireia Piqueras [verfasserIn] Petra Mens [verfasserIn] Henk Schallig [verfasserIn] Japhet Kabalu Tshiongo [verfasserIn] Maminata Traore [verfasserIn] Berenger Kabore [verfasserIn] Edgard Diniba Dabira [verfasserIn] Annette Erhart [verfasserIn] Mohamed Keita [verfasserIn] Thomas PC Dorlo [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2023 |
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Übergeordnetes Werk: |
In: BMJ Open - BMJ Publishing Group, 2011, 13(2023), 10 |
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Übergeordnetes Werk: |
volume:13 ; year:2023 ; number:10 |
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DOI / URN: |
10.1136/bmjopen-2022-065295 |
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Katalog-ID: |
DOAJ091120020 |
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245 | 1 | 0 | |a Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial |
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520 | |a Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. | ||
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10.1136/bmjopen-2022-065295 doi (DE-627)DOAJ091120020 (DE-599)DOAJ931747182e854c4f8d9cee3aaca2a01e DE-627 ger DE-627 rakwb eng Esperanca Sevene verfasserin aut Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. Medicine R Anifa Vala verfasserin aut Salésio Macuacua verfasserin aut Kassoum Kayentao verfasserin aut Issaka Sagara verfasserin aut Halidou Tinto verfasserin aut Clara Menendez verfasserin aut Raquel González verfasserin aut Umberto d'Alessandro verfasserin aut Hamadoun Diakite verfasserin aut Moussa Djimde verfasserin aut Hypolite Mavoko Muhindo verfasserin aut Mireia Piqueras verfasserin aut Petra Mens verfasserin aut Henk Schallig verfasserin aut Japhet Kabalu Tshiongo verfasserin aut Maminata Traore verfasserin aut Berenger Kabore verfasserin aut Edgard Diniba Dabira verfasserin aut Annette Erhart verfasserin aut Mohamed Keita verfasserin aut Thomas PC Dorlo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2022-065295 kostenfrei https://doaj.org/article/931747182e854c4f8d9cee3aaca2a01e kostenfrei https://bmjopen.bmj.com/content/13/10/e065295.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10 |
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10.1136/bmjopen-2022-065295 doi (DE-627)DOAJ091120020 (DE-599)DOAJ931747182e854c4f8d9cee3aaca2a01e DE-627 ger DE-627 rakwb eng Esperanca Sevene verfasserin aut Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. Medicine R Anifa Vala verfasserin aut Salésio Macuacua verfasserin aut Kassoum Kayentao verfasserin aut Issaka Sagara verfasserin aut Halidou Tinto verfasserin aut Clara Menendez verfasserin aut Raquel González verfasserin aut Umberto d'Alessandro verfasserin aut Hamadoun Diakite verfasserin aut Moussa Djimde verfasserin aut Hypolite Mavoko Muhindo verfasserin aut Mireia Piqueras verfasserin aut Petra Mens verfasserin aut Henk Schallig verfasserin aut Japhet Kabalu Tshiongo verfasserin aut Maminata Traore verfasserin aut Berenger Kabore verfasserin aut Edgard Diniba Dabira verfasserin aut Annette Erhart verfasserin aut Mohamed Keita verfasserin aut Thomas PC Dorlo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2022-065295 kostenfrei https://doaj.org/article/931747182e854c4f8d9cee3aaca2a01e kostenfrei https://bmjopen.bmj.com/content/13/10/e065295.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10 |
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10.1136/bmjopen-2022-065295 doi (DE-627)DOAJ091120020 (DE-599)DOAJ931747182e854c4f8d9cee3aaca2a01e DE-627 ger DE-627 rakwb eng Esperanca Sevene verfasserin aut Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. Medicine R Anifa Vala verfasserin aut Salésio Macuacua verfasserin aut Kassoum Kayentao verfasserin aut Issaka Sagara verfasserin aut Halidou Tinto verfasserin aut Clara Menendez verfasserin aut Raquel González verfasserin aut Umberto d'Alessandro verfasserin aut Hamadoun Diakite verfasserin aut Moussa Djimde verfasserin aut Hypolite Mavoko Muhindo verfasserin aut Mireia Piqueras verfasserin aut Petra Mens verfasserin aut Henk Schallig verfasserin aut Japhet Kabalu Tshiongo verfasserin aut Maminata Traore verfasserin aut Berenger Kabore verfasserin aut Edgard Diniba Dabira verfasserin aut Annette Erhart verfasserin aut Mohamed Keita verfasserin aut Thomas PC Dorlo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2022-065295 kostenfrei https://doaj.org/article/931747182e854c4f8d9cee3aaca2a01e kostenfrei https://bmjopen.bmj.com/content/13/10/e065295.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10 |
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10.1136/bmjopen-2022-065295 doi (DE-627)DOAJ091120020 (DE-599)DOAJ931747182e854c4f8d9cee3aaca2a01e DE-627 ger DE-627 rakwb eng Esperanca Sevene verfasserin aut Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. Medicine R Anifa Vala verfasserin aut Salésio Macuacua verfasserin aut Kassoum Kayentao verfasserin aut Issaka Sagara verfasserin aut Halidou Tinto verfasserin aut Clara Menendez verfasserin aut Raquel González verfasserin aut Umberto d'Alessandro verfasserin aut Hamadoun Diakite verfasserin aut Moussa Djimde verfasserin aut Hypolite Mavoko Muhindo verfasserin aut Mireia Piqueras verfasserin aut Petra Mens verfasserin aut Henk Schallig verfasserin aut Japhet Kabalu Tshiongo verfasserin aut Maminata Traore verfasserin aut Berenger Kabore verfasserin aut Edgard Diniba Dabira verfasserin aut Annette Erhart verfasserin aut Mohamed Keita verfasserin aut Thomas PC Dorlo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2022-065295 kostenfrei https://doaj.org/article/931747182e854c4f8d9cee3aaca2a01e kostenfrei https://bmjopen.bmj.com/content/13/10/e065295.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10 |
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10.1136/bmjopen-2022-065295 doi (DE-627)DOAJ091120020 (DE-599)DOAJ931747182e854c4f8d9cee3aaca2a01e DE-627 ger DE-627 rakwb eng Esperanca Sevene verfasserin aut Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. Medicine R Anifa Vala verfasserin aut Salésio Macuacua verfasserin aut Kassoum Kayentao verfasserin aut Issaka Sagara verfasserin aut Halidou Tinto verfasserin aut Clara Menendez verfasserin aut Raquel González verfasserin aut Umberto d'Alessandro verfasserin aut Hamadoun Diakite verfasserin aut Moussa Djimde verfasserin aut Hypolite Mavoko Muhindo verfasserin aut Mireia Piqueras verfasserin aut Petra Mens verfasserin aut Henk Schallig verfasserin aut Japhet Kabalu Tshiongo verfasserin aut Maminata Traore verfasserin aut Berenger Kabore verfasserin aut Edgard Diniba Dabira verfasserin aut Annette Erhart verfasserin aut Mohamed Keita verfasserin aut Thomas PC Dorlo verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2022-065295 kostenfrei https://doaj.org/article/931747182e854c4f8d9cee3aaca2a01e kostenfrei https://bmjopen.bmj.com/content/13/10/e065295.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10 |
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Esperanca Sevene @@aut@@ Anifa Vala @@aut@@ Salésio Macuacua @@aut@@ Kassoum Kayentao @@aut@@ Issaka Sagara @@aut@@ Halidou Tinto @@aut@@ Clara Menendez @@aut@@ Raquel González @@aut@@ Umberto d'Alessandro @@aut@@ Hamadoun Diakite @@aut@@ Moussa Djimde @@aut@@ Hypolite Mavoko Muhindo @@aut@@ Mireia Piqueras @@aut@@ Petra Mens @@aut@@ Henk Schallig @@aut@@ Japhet Kabalu Tshiongo @@aut@@ Maminata Traore @@aut@@ Berenger Kabore @@aut@@ Edgard Diniba Dabira @@aut@@ Annette Erhart @@aut@@ Mohamed Keita @@aut@@ Thomas PC Dorlo @@aut@@ |
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Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial |
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Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial |
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Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial |
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Esperanca Sevene Anifa Vala Salésio Macuacua Kassoum Kayentao Issaka Sagara Halidou Tinto Clara Menendez Raquel González Umberto d'Alessandro Hamadoun Diakite Moussa Djimde Hypolite Mavoko Muhindo Mireia Piqueras Petra Mens Henk Schallig Japhet Kabalu Tshiongo Maminata Traore Berenger Kabore Edgard Diniba Dabira Annette Erhart Mohamed Keita Thomas PC Dorlo |
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efficacy and safety of pyronaridine-artesunate (pyramax) for the treatment of p. falciparum uncomplicated malaria in african pregnant women (pyrapreg): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial |
title_auth |
Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial |
abstract |
Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. |
abstractGer |
Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. |
abstract_unstemmed |
Introduction Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP). Pyronaridine-artesunate (PA) is a new artemisinin-based combination. The main objective of this study is to determine the efficacy and safety of PA versus AL or DP when administered to pregnant women with confirmed Plasmodium falciparum infection in the second or third trimester. The primary hypothesis is the pairwise non-inferiority of PA as compared with either AL or DP.Methods and analysis A phase 3, non-inferiority, randomised, open-label clinical trial to determine the safety and efficacy of AL, DP and PA in pregnant women with malaria in five sub-Saharan, malaria-endemic countries (Burkina Faso, Democratic Republic of the Congo, Mali, Mozambique and the Gambia). A total of 1875 pregnant women will be randomised to one of the treatment arms. Women will be actively monitored until Day 63 post-treatment, at delivery and 4–6 weeks after delivery, and infants’ health will be checked on their first birthday. The primary endpoint is the PCR-adjusted rate of adequate clinical and parasitological response at Day 42 in the per-protocol population.Ethics and dissemination This protocol has been approved by the Ethics Committee for Health Research in Burkina Faso, the National Health Ethics Committee in the Democratic Republic of Congo, the Ethics Committee of the Faculty of Medicine and Odontostomatology/Faculty of Pharmacy in Mali, the Gambia Government/MRCG Joint Ethics Committee and the National Bioethics Committee for Health in Mozambique. Written informed consent will be obtained from each individual prior to her participation in the study. The results will be published in peer-reviewed open access journals and presented at (inter)national conferences and meetings.Trial registration number PACTR202011812241529. |
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Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial |
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