LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway

Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro...
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Autor*in:	Rongrong Zhang [verfasserIn] Yating Zhan [verfasserIn] Zhichao Lang [verfasserIn] Yifei Li [verfasserIn] Weizhi Zhang [verfasserIn] Jianjian Zheng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Übergeordnetes Werk:	In: Communications Biology - Nature Portfolio, 2018, 7(2024), 1, Seite 11
Übergeordnetes Werk:	volume:7 ; year:2024 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s42003-024-05971-7

Katalog-ID:	DOAJ091164370

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520			\|a Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway.
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allfields	10.1038/s42003-024-05971-7 doi (DE-627)DOAJ091164370 (DE-599)DOAJ5585681571dd4c89b66f856054484a81 DE-627 ger DE-627 rakwb eng QH301-705.5 Rongrong Zhang verfasserin aut LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway. Biology (General) Yating Zhan verfasserin aut Zhichao Lang verfasserin aut Yifei Li verfasserin aut Weizhi Zhang verfasserin aut Jianjian Zheng verfasserin aut In Communications Biology Nature Portfolio, 2018 7(2024), 1, Seite 11 (DE-627)101369080X 23993642 nnns volume:7 year:2024 number:1 pages:11 https://doi.org/10.1038/s42003-024-05971-7 kostenfrei https://doaj.org/article/5585681571dd4c89b66f856054484a81 kostenfrei https://doi.org/10.1038/s42003-024-05971-7 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2024 1 11
spelling	10.1038/s42003-024-05971-7 doi (DE-627)DOAJ091164370 (DE-599)DOAJ5585681571dd4c89b66f856054484a81 DE-627 ger DE-627 rakwb eng QH301-705.5 Rongrong Zhang verfasserin aut LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway. Biology (General) Yating Zhan verfasserin aut Zhichao Lang verfasserin aut Yifei Li verfasserin aut Weizhi Zhang verfasserin aut Jianjian Zheng verfasserin aut In Communications Biology Nature Portfolio, 2018 7(2024), 1, Seite 11 (DE-627)101369080X 23993642 nnns volume:7 year:2024 number:1 pages:11 https://doi.org/10.1038/s42003-024-05971-7 kostenfrei https://doaj.org/article/5585681571dd4c89b66f856054484a81 kostenfrei https://doi.org/10.1038/s42003-024-05971-7 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2024 1 11
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allfieldsSound	10.1038/s42003-024-05971-7 doi (DE-627)DOAJ091164370 (DE-599)DOAJ5585681571dd4c89b66f856054484a81 DE-627 ger DE-627 rakwb eng QH301-705.5 Rongrong Zhang verfasserin aut LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway. Biology (General) Yating Zhan verfasserin aut Zhichao Lang verfasserin aut Yifei Li verfasserin aut Weizhi Zhang verfasserin aut Jianjian Zheng verfasserin aut In Communications Biology Nature Portfolio, 2018 7(2024), 1, Seite 11 (DE-627)101369080X 23993642 nnns volume:7 year:2024 number:1 pages:11 https://doi.org/10.1038/s42003-024-05971-7 kostenfrei https://doaj.org/article/5585681571dd4c89b66f856054484a81 kostenfrei https://doi.org/10.1038/s42003-024-05971-7 kostenfrei https://doaj.org/toc/2399-3642 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2024 1 11
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author	Rongrong Zhang
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topic_title	QH301-705.5 LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway
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title	LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway
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title_full	LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway
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title_auth	LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway
abstract	Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway.
abstractGer	Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway.
abstract_unstemmed	Abstract Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was found to be upregulated in activated HSCs in vitro and in primary HSCs isolated from fibrotic liver in vivo, and inhibition of SNHG5 suppressed HSC activation. Notably, Neurofibromin 2 (NF2), the main activator for Hippo signalling, was involved in the effects of SNHG5 on HSC activation. The interaction between SNHG5 and NF2 protein was further confirmed, and preventing the combination of the two could effectively block the effects of SNHG5 inhibition on EMT process and Hippo signaling. Additionally, higher SNHG5 was found in chronic hepatitis B patients and associated with the fibrosis stage. Altogether, we demonstrate that SNHG5 could serve as an activated HSCs regulator via regulating NF2 and Hippo pathway.
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title_short	LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway
url	https://doi.org/10.1038/s42003-024-05971-7 https://doaj.org/article/5585681571dd4c89b66f856054484a81 https://doaj.org/toc/2399-3642
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LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway

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