Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects

Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Trehan A [verfasserIn] Anand R [verfasserIn] Chaudhary G [verfasserIn] Garg H [verfasserIn] Verma MK [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity

Übergeordnetes Werk:	In: Clinical, Cosmetic and Investigational Dermatology - Dove Medical Press, 2009, (2024), Seite 581-591
Übergeordnetes Werk:	year:2024 ; pages:581-591

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ091225272

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ091225272
003	DE-627
005	20240413232153.0
007	cr uuu---uuuuu
008	240412s2024 xx \|\|\|\|\|o 00\| \|\|eng c
035			\|a (DE-627)DOAJ091225272
035			\|a (DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RL1-803
100	0		\|a Trehan A \|e verfasserin \|4 aut
245	1	0	\|a Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects
264		1	\|c 2024
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity
650		4	\|a skin hydration
650		4	\|a skin roughness
650		4	\|a hair fall reduction
650		4	\|a crow’s feet wrinkles
650		4	\|a skin elasticity
653		0	\|a Dermatology
700	0		\|a Anand R \|e verfasserin \|4 aut
700	0		\|a Chaudhary G \|e verfasserin \|4 aut
700	0		\|a Garg H \|e verfasserin \|4 aut
700	0		\|a Verma MK \|e verfasserin \|4 aut
773	0	8	\|i In \|t Clinical, Cosmetic and Investigational Dermatology \|d Dove Medical Press, 2009 \|g (2024), Seite 581-591 \|w (DE-627)600305953 \|w (DE-600)2494852-4 \|x 11787015 \|7 nnns
773	1	8	\|g year:2024 \|g pages:581-591
856	4	0	\|u https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34 \|z kostenfrei
856	4	0	\|u https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/1178-7015 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|j 2024 \|h 581-591

Indexfelder

author_variant	t a ta a r ar c g cg g h gh v m vm
matchkey_str	article:11787015:2024----::fiaynsftosirdacclaeosiadararxpaeootoldln
hierarchy_sort_str	2024
callnumber-subject-code	RL
publishDate	2024
allfields	(DE-627)DOAJ091225272 (DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34 DE-627 ger DE-627 rakwb eng RL1-803 Trehan A verfasserin aut Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity Dermatology Anand R verfasserin aut Chaudhary G verfasserin aut Garg H verfasserin aut Verma MK verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2024), Seite 581-591 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2024 pages:581-591 https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34 kostenfrei https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 581-591
spelling	(DE-627)DOAJ091225272 (DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34 DE-627 ger DE-627 rakwb eng RL1-803 Trehan A verfasserin aut Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity Dermatology Anand R verfasserin aut Chaudhary G verfasserin aut Garg H verfasserin aut Verma MK verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2024), Seite 581-591 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2024 pages:581-591 https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34 kostenfrei https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 581-591
allfields_unstemmed	(DE-627)DOAJ091225272 (DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34 DE-627 ger DE-627 rakwb eng RL1-803 Trehan A verfasserin aut Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity Dermatology Anand R verfasserin aut Chaudhary G verfasserin aut Garg H verfasserin aut Verma MK verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2024), Seite 581-591 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2024 pages:581-591 https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34 kostenfrei https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 581-591
allfieldsGer	(DE-627)DOAJ091225272 (DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34 DE-627 ger DE-627 rakwb eng RL1-803 Trehan A verfasserin aut Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity Dermatology Anand R verfasserin aut Chaudhary G verfasserin aut Garg H verfasserin aut Verma MK verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2024), Seite 581-591 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2024 pages:581-591 https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34 kostenfrei https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 581-591
allfieldsSound	(DE-627)DOAJ091225272 (DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34 DE-627 ger DE-627 rakwb eng RL1-803 Trehan A verfasserin aut Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity Dermatology Anand R verfasserin aut Chaudhary G verfasserin aut Garg H verfasserin aut Verma MK verfasserin aut In Clinical, Cosmetic and Investigational Dermatology Dove Medical Press, 2009 (2024), Seite 581-591 (DE-627)600305953 (DE-600)2494852-4 11787015 nnns year:2024 pages:581-591 https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34 kostenfrei https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID kostenfrei https://doaj.org/toc/1178-7015 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 581-591
language	English
source	In Clinical, Cosmetic and Investigational Dermatology (2024), Seite 581-591 year:2024 pages:581-591
sourceStr	In Clinical, Cosmetic and Investigational Dermatology (2024), Seite 581-591 year:2024 pages:581-591
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity Dermatology
isfreeaccess_bool	true
container_title	Clinical, Cosmetic and Investigational Dermatology
authorswithroles_txt_mv	Trehan A @@aut@@ Anand R @@aut@@ Chaudhary G @@aut@@ Garg H @@aut@@ Verma MK @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	600305953
id	DOAJ091225272
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ091225272</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413232153.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240412s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ091225272</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RL1-803</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Trehan A</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin hydration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin roughness</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hair fall reduction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">crow’s feet wrinkles</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin elasticity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Dermatology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anand R</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chaudhary G</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Garg H</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Verma MK</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Clinical, Cosmetic and Investigational Dermatology</subfield><subfield code="d">Dove Medical Press, 2009</subfield><subfield code="g">(2024), Seite 581-591</subfield><subfield code="w">(DE-627)600305953</subfield><subfield code="w">(DE-600)2494852-4</subfield><subfield code="x">11787015</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">year:2024</subfield><subfield code="g">pages:581-591</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1178-7015</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="j">2024</subfield><subfield code="h">581-591</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Trehan A
spellingShingle	Trehan A misc RL1-803 misc skin hydration misc skin roughness misc hair fall reduction misc crow’s feet wrinkles misc skin elasticity misc Dermatology Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects
authorStr	Trehan A
ppnlink_with_tag_str_mv	@@773@@(DE-627)600305953
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RL1-803
illustrated	Not Illustrated
issn	11787015
topic_title	RL1-803 Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects skin hydration skin roughness hair fall reduction crow’s feet wrinkles skin elasticity
topic	misc RL1-803 misc skin hydration misc skin roughness misc hair fall reduction misc crow’s feet wrinkles misc skin elasticity misc Dermatology
topic_unstemmed	misc RL1-803 misc skin hydration misc skin roughness misc hair fall reduction misc crow’s feet wrinkles misc skin elasticity misc Dermatology
topic_browse	misc RL1-803 misc skin hydration misc skin roughness misc hair fall reduction misc crow’s feet wrinkles misc skin elasticity misc Dermatology
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Clinical, Cosmetic and Investigational Dermatology
hierarchy_parent_id	600305953
hierarchy_top_title	Clinical, Cosmetic and Investigational Dermatology
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)600305953 (DE-600)2494852-4
title	Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects
ctrlnum	(DE-627)DOAJ091225272 (DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34
title_full	Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects
author_sort	Trehan A
journal	Clinical, Cosmetic and Investigational Dermatology
journalStr	Clinical, Cosmetic and Investigational Dermatology
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2024
contenttype_str_mv	txt
container_start_page	581
author_browse	Trehan A Anand R Chaudhary G Garg H Verma MK
class	RL1-803
format_se	Elektronische Aufsätze
author-letter	Trehan A
author2-role	verfasserin
title_sort	efficacy and safety of skin radiance collagen on skin and hair matrix: a placebo-controlled clinical trial in healthy human subjects
callnumber	RL1-803
title_auth	Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects
abstract	Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity
abstractGer	Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity
abstract_unstemmed	Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
title_short	Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects
url	https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34 https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID https://doaj.org/toc/1178-7015
remote_bool	true
author2	Anand R Chaudhary G Garg H Verma MK
author2Str	Anand R Chaudhary G Garg H Verma MK
ppnlink	600305953
callnumber-subject	RL - Dermatology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
callnumber-a	RL1-803
up_date	2024-07-03T19:12:30.795Z
_version_	1803586319993012224
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ091225272</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413232153.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240412s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ091225272</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ96b366ab83c54d5ebefbbf6a4bca5a34</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RL1-803</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Trehan A</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Anupam Trehan, Rachna Anand, Garima Chaudhary, Himanshi Garg, Manoj Kumar Verma Bright Lifecare Pvt. Ltd, Gurugram, Haryana, IndiaCorrespondence: Rachna Anand, Bright Lifecare Pvt. Ltd, The Presidency, Tower B, Second Floor, 46/4, M G Road, Sector-14, Opp. Girls College, Gurgaon, Haryana, 122001, India, Email rachna.anandbrightlifecare.comPurpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.Patients and Methods: Forty healthy adult non-pregnant/non-lactating women (aged 38– 50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow’s feet region; as well as hair strength and hair fall.Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value < 0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value < 0.01.Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow’s feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.Keywords: skin hydration, skin roughness, hair fall reduction, crow’s feet wrinkles, skin elasticity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin hydration</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin roughness</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hair fall reduction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">crow’s feet wrinkles</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">skin elasticity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Dermatology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anand R</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chaudhary G</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Garg H</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Verma MK</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Clinical, Cosmetic and Investigational Dermatology</subfield><subfield code="d">Dove Medical Press, 2009</subfield><subfield code="g">(2024), Seite 581-591</subfield><subfield code="w">(DE-627)600305953</subfield><subfield code="w">(DE-600)2494852-4</subfield><subfield code="x">11787015</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">year:2024</subfield><subfield code="g">pages:581-591</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/96b366ab83c54d5ebefbbf6a4bca5a34</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.dovepress.com/efficacy-and-safety-of-skin-radiance-collagen-on-skin-and-hair-matrix--peer-reviewed-fulltext-article-CCID</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1178-7015</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="j">2024</subfield><subfield code="h">581-591</subfield></datafield></record></collection>
score	7.4014044

Nicht das Richtige dabei?

Schreiben Sie uns!

Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?