Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children

<b<Background/Objectives:</b< Precise assessment of hypnotic depth in children during procedural sedation with preserved spontaneous breathing is challenging. The Narcotrendindex (NI) offers uninterrupted information by continuous electrocortical monitoring without the need to apply a st...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Nora Bruns [verfasserIn] Carolina A. Joist [verfasserIn] Constantin M. Joist [verfasserIn] Anna Daniels [verfasserIn] Ursula Felderhoff-Müser [verfasserIn] Christian Dohna-Schwake [verfasserIn] Eva Tschiedel [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	children procedural sedation propofol midazolam sedation monitoring depth of sedation

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 13(2024), 5, p 1483
Übergeordnetes Werk:	volume:13 ; year:2024 ; number:5, p 1483

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm13051483

Katalog-ID:	DOAJ091252237

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520			\|a <b<Background/Objectives:</b< Precise assessment of hypnotic depth in children during procedural sedation with preserved spontaneous breathing is challenging. The Narcotrendindex (NI) offers uninterrupted information by continuous electrocortical monitoring without the need to apply a stimulus with the risk of assessment-induced arousal. This study aimed to explore the correlation between NI and the Comfort Scale (CS) during procedural sedation with midazolam and propofol and to identify an NI target range for deep sedation. <b<Methods:</b< A prospective observational study was conducted on 176 children (6 months to 17.9 years) undergoing procedural sedation with midazolam premedication and continuous propofol infusion. Statistical analyses included Pearson correlation of NI and CS values, logistic regression, and receiver operating curves. <b<Results:</b< Median NI values varied with CS and age. The correlation coefficient between CS and NI was 0.50 and slightly higher in procedure-specific subgroup analyses. The optimal NI cut-off for deep sedation was between 50 and 60 depending on the analyzed subgroup and displayed high positive predictive values for sufficient sedation throughout. <b<Conclusion:</b< Our study found a moderate correlation between NI and CS, demonstrating reliable identification of adequately sedated patients.
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allfieldsSound	10.3390/jcm13051483 doi (DE-627)DOAJ091252237 (DE-599)DOAJ1ff7e658af9e4b1fa48eab7cf5dc9f0b DE-627 ger DE-627 rakwb eng Nora Bruns verfasserin aut Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background/Objectives:</b< Precise assessment of hypnotic depth in children during procedural sedation with preserved spontaneous breathing is challenging. The Narcotrendindex (NI) offers uninterrupted information by continuous electrocortical monitoring without the need to apply a stimulus with the risk of assessment-induced arousal. This study aimed to explore the correlation between NI and the Comfort Scale (CS) during procedural sedation with midazolam and propofol and to identify an NI target range for deep sedation. <b<Methods:</b< A prospective observational study was conducted on 176 children (6 months to 17.9 years) undergoing procedural sedation with midazolam premedication and continuous propofol infusion. Statistical analyses included Pearson correlation of NI and CS values, logistic regression, and receiver operating curves. <b<Results:</b< Median NI values varied with CS and age. The correlation coefficient between CS and NI was 0.50 and slightly higher in procedure-specific subgroup analyses. The optimal NI cut-off for deep sedation was between 50 and 60 depending on the analyzed subgroup and displayed high positive predictive values for sufficient sedation throughout. <b<Conclusion:</b< Our study found a moderate correlation between NI and CS, demonstrating reliable identification of adequately sedated patients. children procedural sedation propofol midazolam sedation monitoring depth of sedation Medicine R Carolina A. Joist verfasserin aut Constantin M. Joist verfasserin aut Anna Daniels verfasserin aut Ursula Felderhoff-Müser verfasserin aut Christian Dohna-Schwake verfasserin aut Eva Tschiedel verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2024), 5, p 1483 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2024 number:5, p 1483 https://doi.org/10.3390/jcm13051483 kostenfrei https://doaj.org/article/1ff7e658af9e4b1fa48eab7cf5dc9f0b kostenfrei https://www.mdpi.com/2077-0383/13/5/1483 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 5, p 1483
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author	Nora Bruns
spellingShingle	Nora Bruns misc children misc procedural sedation misc propofol misc midazolam misc sedation monitoring misc depth of sedation misc Medicine misc R Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children
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topic_title	Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children children procedural sedation propofol midazolam sedation monitoring depth of sedation
topic	misc children misc procedural sedation misc propofol misc midazolam misc sedation monitoring misc depth of sedation misc Medicine misc R
topic_unstemmed	misc children misc procedural sedation misc propofol misc midazolam misc sedation monitoring misc depth of sedation misc Medicine misc R
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title	Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children
ctrlnum	(DE-627)DOAJ091252237 (DE-599)DOAJ1ff7e658af9e4b1fa48eab7cf5dc9f0b
title_full	Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children
author_sort	Nora Bruns
journal	Journal of Clinical Medicine
journalStr	Journal of Clinical Medicine
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author_browse	Nora Bruns Carolina A. Joist Constantin M. Joist Anna Daniels Ursula Felderhoff-Müser Christian Dohna-Schwake Eva Tschiedel
container_volume	13
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title_sort	correlation of comfort score and narcotrend index during procedural sedation with midazolam and propofol in children
title_auth	Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children
abstract	<b<Background/Objectives:</b< Precise assessment of hypnotic depth in children during procedural sedation with preserved spontaneous breathing is challenging. The Narcotrendindex (NI) offers uninterrupted information by continuous electrocortical monitoring without the need to apply a stimulus with the risk of assessment-induced arousal. This study aimed to explore the correlation between NI and the Comfort Scale (CS) during procedural sedation with midazolam and propofol and to identify an NI target range for deep sedation. <b<Methods:</b< A prospective observational study was conducted on 176 children (6 months to 17.9 years) undergoing procedural sedation with midazolam premedication and continuous propofol infusion. Statistical analyses included Pearson correlation of NI and CS values, logistic regression, and receiver operating curves. <b<Results:</b< Median NI values varied with CS and age. The correlation coefficient between CS and NI was 0.50 and slightly higher in procedure-specific subgroup analyses. The optimal NI cut-off for deep sedation was between 50 and 60 depending on the analyzed subgroup and displayed high positive predictive values for sufficient sedation throughout. <b<Conclusion:</b< Our study found a moderate correlation between NI and CS, demonstrating reliable identification of adequately sedated patients.
abstractGer	<b<Background/Objectives:</b< Precise assessment of hypnotic depth in children during procedural sedation with preserved spontaneous breathing is challenging. The Narcotrendindex (NI) offers uninterrupted information by continuous electrocortical monitoring without the need to apply a stimulus with the risk of assessment-induced arousal. This study aimed to explore the correlation between NI and the Comfort Scale (CS) during procedural sedation with midazolam and propofol and to identify an NI target range for deep sedation. <b<Methods:</b< A prospective observational study was conducted on 176 children (6 months to 17.9 years) undergoing procedural sedation with midazolam premedication and continuous propofol infusion. Statistical analyses included Pearson correlation of NI and CS values, logistic regression, and receiver operating curves. <b<Results:</b< Median NI values varied with CS and age. The correlation coefficient between CS and NI was 0.50 and slightly higher in procedure-specific subgroup analyses. The optimal NI cut-off for deep sedation was between 50 and 60 depending on the analyzed subgroup and displayed high positive predictive values for sufficient sedation throughout. <b<Conclusion:</b< Our study found a moderate correlation between NI and CS, demonstrating reliable identification of adequately sedated patients.
abstract_unstemmed	<b<Background/Objectives:</b< Precise assessment of hypnotic depth in children during procedural sedation with preserved spontaneous breathing is challenging. The Narcotrendindex (NI) offers uninterrupted information by continuous electrocortical monitoring without the need to apply a stimulus with the risk of assessment-induced arousal. This study aimed to explore the correlation between NI and the Comfort Scale (CS) during procedural sedation with midazolam and propofol and to identify an NI target range for deep sedation. <b<Methods:</b< A prospective observational study was conducted on 176 children (6 months to 17.9 years) undergoing procedural sedation with midazolam premedication and continuous propofol infusion. Statistical analyses included Pearson correlation of NI and CS values, logistic regression, and receiver operating curves. <b<Results:</b< Median NI values varied with CS and age. The correlation coefficient between CS and NI was 0.50 and slightly higher in procedure-specific subgroup analyses. The optimal NI cut-off for deep sedation was between 50 and 60 depending on the analyzed subgroup and displayed high positive predictive values for sufficient sedation throughout. <b<Conclusion:</b< Our study found a moderate correlation between NI and CS, demonstrating reliable identification of adequately sedated patients.
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container_issue	5, p 1483
title_short	Correlation of Comfort Score and Narcotrend Index during Procedural Sedation with Midazolam and Propofol in Children
url	https://doi.org/10.3390/jcm13051483 https://doaj.org/article/1ff7e658af9e4b1fa48eab7cf5dc9f0b https://www.mdpi.com/2077-0383/13/5/1483 https://doaj.org/toc/2077-0383
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author2	Carolina A. Joist Constantin M. Joist Anna Daniels Ursula Felderhoff-Müser Christian Dohna-Schwake Eva Tschiedel
author2Str	Carolina A. Joist Constantin M. Joist Anna Daniels Ursula Felderhoff-Müser Christian Dohna-Schwake Eva Tschiedel
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up_date	2024-07-03T19:22:15.758Z
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