Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(<i<N</i<-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels

Photoinduced metal-free ATRP has been successfully applied to fabricate thermo-responsive cellulose graft copolymer (PNIPAM-<i<g</i<-Cell) using 2-bromoisobuturyl bromide-modified cellulose as the macroinitiator. The polymerization of N-isopropylacrylamide (NIPAM) from cellulose was effi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Xiaohong Liu [verfasserIn] Juanli Shen [verfasserIn] Ying Wang [verfasserIn] Ming Li [verfasserIn] Shiyu Fu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	metal-free ATRP UV irradiation cellulose injectable hydrogel

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 25(2024), 5, p 2867
Übergeordnetes Werk:	volume:25 ; year:2024 ; number:5, p 2867

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms25052867

Katalog-ID:	DOAJ091257425

Internformat


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sourceStr	In International Journal of Molecular Sciences 25(2024), 5, p 2867 volume:25 year:2024 number:5, p 2867
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callnumber-first	Q - Science
author	Xiaohong Liu
spellingShingle	Xiaohong Liu misc QH301-705.5 misc QD1-999 misc metal-free ATRP misc UV irradiation misc cellulose misc injectable hydrogel misc Biology (General) misc Chemistry Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(<i<N</i<-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels
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topic_title	QH301-705.5 QD1-999 Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(<i<N</i<-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels metal-free ATRP UV irradiation cellulose injectable hydrogel
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title	Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(<i<N</i<-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels
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title_sort	photoinduced metal-free atom transfer radical polymerization for the modification of cellulose with poly(<i<n</i<-isopropylacrylamide) to create thermo-responsive injectable hydrogels
callnumber	QH301-705.5
title_auth	Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(<i<N</i<-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels
abstract	Photoinduced metal-free ATRP has been successfully applied to fabricate thermo-responsive cellulose graft copolymer (PNIPAM-<i<g</i<-Cell) using 2-bromoisobuturyl bromide-modified cellulose as the macroinitiator. The polymerization of N-isopropylacrylamide (NIPAM) from cellulose was efficiently activated and deactivated with UV irradiation in the presence of an organic-based photo-redox catalyst. Both FTIR and <sup<13</sup<C NMR analysis confirmed the structural similarity between the obtained PNIPAM-<i<g</i<-Cell and that synthesized via traditional ATRP methods. When the concentration of the PNIPAM-<i<g</i<-Cell is over 5% in water, it forms an injectable thermos-responsive hydrogel composed of micelles at 37 °C. Since organic photocatalysis is a metal-free ATRP, it overcomes the challenge of transition-metal catalysts remaining in polymer products, making this cellulose-based graft copolymer suitable for biomedical applications. In vitro release studies demonstrated that the hydrogel can continuously release DOX for up to 10 days, and its cytotoxicity indicates that it is highly biocompatible. Based on these findings, this cellulose-based injectable, thermo-responsive drug-loaded hydrogel is suitable for intelligent drug delivery systems.
abstractGer	Photoinduced metal-free ATRP has been successfully applied to fabricate thermo-responsive cellulose graft copolymer (PNIPAM-<i<g</i<-Cell) using 2-bromoisobuturyl bromide-modified cellulose as the macroinitiator. The polymerization of N-isopropylacrylamide (NIPAM) from cellulose was efficiently activated and deactivated with UV irradiation in the presence of an organic-based photo-redox catalyst. Both FTIR and <sup<13</sup<C NMR analysis confirmed the structural similarity between the obtained PNIPAM-<i<g</i<-Cell and that synthesized via traditional ATRP methods. When the concentration of the PNIPAM-<i<g</i<-Cell is over 5% in water, it forms an injectable thermos-responsive hydrogel composed of micelles at 37 °C. Since organic photocatalysis is a metal-free ATRP, it overcomes the challenge of transition-metal catalysts remaining in polymer products, making this cellulose-based graft copolymer suitable for biomedical applications. In vitro release studies demonstrated that the hydrogel can continuously release DOX for up to 10 days, and its cytotoxicity indicates that it is highly biocompatible. Based on these findings, this cellulose-based injectable, thermo-responsive drug-loaded hydrogel is suitable for intelligent drug delivery systems.
abstract_unstemmed	Photoinduced metal-free ATRP has been successfully applied to fabricate thermo-responsive cellulose graft copolymer (PNIPAM-<i<g</i<-Cell) using 2-bromoisobuturyl bromide-modified cellulose as the macroinitiator. The polymerization of N-isopropylacrylamide (NIPAM) from cellulose was efficiently activated and deactivated with UV irradiation in the presence of an organic-based photo-redox catalyst. Both FTIR and <sup<13</sup<C NMR analysis confirmed the structural similarity between the obtained PNIPAM-<i<g</i<-Cell and that synthesized via traditional ATRP methods. When the concentration of the PNIPAM-<i<g</i<-Cell is over 5% in water, it forms an injectable thermos-responsive hydrogel composed of micelles at 37 °C. Since organic photocatalysis is a metal-free ATRP, it overcomes the challenge of transition-metal catalysts remaining in polymer products, making this cellulose-based graft copolymer suitable for biomedical applications. In vitro release studies demonstrated that the hydrogel can continuously release DOX for up to 10 days, and its cytotoxicity indicates that it is highly biocompatible. Based on these findings, this cellulose-based injectable, thermo-responsive drug-loaded hydrogel is suitable for intelligent drug delivery systems.
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title_short	Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(<i<N</i<-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels
url	https://doi.org/10.3390/ijms25052867 https://doaj.org/article/0916d9aaa21a41338131da320f5ea0ec https://www.mdpi.com/1422-0067/25/5/2867 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T19:24:17.986Z
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Photoinduced Metal-Free Atom Transfer Radical Polymerization for the Modification of Cellulose with Poly(<i<N</i<-isopropylacrylamide) to Create Thermo-Responsive Injectable Hydrogels

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