Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population
Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examina...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Guzel S. Isaeva [verfasserIn] Albina Z. Zaripova [verfasserIn] Lira T. Bayazitova [verfasserIn] Ralina M. Khusainova [verfasserIn] Tatiana A. Chazova [verfasserIn] Olga F. Tyupkina [verfasserIn] Ekaterina V. Nikitina [verfasserIn] Irina A. Tsvetkova [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Russisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Журнал микробиологии, эпидемиологии и иммунобиологии - Central Research Institute for Epidemiology, 2020, 101(2024), 1, Seite 89-99 |
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| Übergeordnetes Werk: |
volume:101 ; year:2024 ; number:1 ; pages:89-99 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.36233/0372-9311-445 |
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| Katalog-ID: |
DOAJ091326524 |
|---|
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| 520 | |a Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. | ||
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| 700 | 0 | |a Olga F. Tyupkina |e verfasserin |4 aut | |
| 700 | 0 | |a Ekaterina V. Nikitina |e verfasserin |4 aut | |
| 700 | 0 | |a Irina A. Tsvetkova |e verfasserin |4 aut | |
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10.36233/0372-9311-445 doi (DE-627)DOAJ091326524 (DE-599)DOAJcf1ef4cfcfc74e4d81cf0a000097c34c DE-627 ger DE-627 rakwb rus QR1-502 Guzel S. Isaeva verfasserin aut Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. streptococcus pneumoniae bacterial carrier serotypes sequence types Microbiology Albina Z. Zaripova verfasserin aut Lira T. Bayazitova verfasserin aut Ralina M. Khusainova verfasserin aut Tatiana A. Chazova verfasserin aut Olga F. Tyupkina verfasserin aut Ekaterina V. Nikitina verfasserin aut Irina A. Tsvetkova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 101(2024), 1, Seite 89-99 (DE-627)1760649171 26867613 nnns volume:101 year:2024 number:1 pages:89-99 https://doi.org/10.36233/0372-9311-445 kostenfrei https://doaj.org/article/cf1ef4cfcfc74e4d81cf0a000097c34c kostenfrei https://microbiol.crie.ru/jour/article/viewFile/18556/1406 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 101 2024 1 89-99 |
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10.36233/0372-9311-445 doi (DE-627)DOAJ091326524 (DE-599)DOAJcf1ef4cfcfc74e4d81cf0a000097c34c DE-627 ger DE-627 rakwb rus QR1-502 Guzel S. Isaeva verfasserin aut Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. streptococcus pneumoniae bacterial carrier serotypes sequence types Microbiology Albina Z. Zaripova verfasserin aut Lira T. Bayazitova verfasserin aut Ralina M. Khusainova verfasserin aut Tatiana A. Chazova verfasserin aut Olga F. Tyupkina verfasserin aut Ekaterina V. Nikitina verfasserin aut Irina A. Tsvetkova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 101(2024), 1, Seite 89-99 (DE-627)1760649171 26867613 nnns volume:101 year:2024 number:1 pages:89-99 https://doi.org/10.36233/0372-9311-445 kostenfrei https://doaj.org/article/cf1ef4cfcfc74e4d81cf0a000097c34c kostenfrei https://microbiol.crie.ru/jour/article/viewFile/18556/1406 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 101 2024 1 89-99 |
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10.36233/0372-9311-445 doi (DE-627)DOAJ091326524 (DE-599)DOAJcf1ef4cfcfc74e4d81cf0a000097c34c DE-627 ger DE-627 rakwb rus QR1-502 Guzel S. Isaeva verfasserin aut Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. streptococcus pneumoniae bacterial carrier serotypes sequence types Microbiology Albina Z. Zaripova verfasserin aut Lira T. Bayazitova verfasserin aut Ralina M. Khusainova verfasserin aut Tatiana A. Chazova verfasserin aut Olga F. Tyupkina verfasserin aut Ekaterina V. Nikitina verfasserin aut Irina A. Tsvetkova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 101(2024), 1, Seite 89-99 (DE-627)1760649171 26867613 nnns volume:101 year:2024 number:1 pages:89-99 https://doi.org/10.36233/0372-9311-445 kostenfrei https://doaj.org/article/cf1ef4cfcfc74e4d81cf0a000097c34c kostenfrei https://microbiol.crie.ru/jour/article/viewFile/18556/1406 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 101 2024 1 89-99 |
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10.36233/0372-9311-445 doi (DE-627)DOAJ091326524 (DE-599)DOAJcf1ef4cfcfc74e4d81cf0a000097c34c DE-627 ger DE-627 rakwb rus QR1-502 Guzel S. Isaeva verfasserin aut Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. streptococcus pneumoniae bacterial carrier serotypes sequence types Microbiology Albina Z. Zaripova verfasserin aut Lira T. Bayazitova verfasserin aut Ralina M. Khusainova verfasserin aut Tatiana A. Chazova verfasserin aut Olga F. Tyupkina verfasserin aut Ekaterina V. Nikitina verfasserin aut Irina A. Tsvetkova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 101(2024), 1, Seite 89-99 (DE-627)1760649171 26867613 nnns volume:101 year:2024 number:1 pages:89-99 https://doi.org/10.36233/0372-9311-445 kostenfrei https://doaj.org/article/cf1ef4cfcfc74e4d81cf0a000097c34c kostenfrei https://microbiol.crie.ru/jour/article/viewFile/18556/1406 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 101 2024 1 89-99 |
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10.36233/0372-9311-445 doi (DE-627)DOAJ091326524 (DE-599)DOAJcf1ef4cfcfc74e4d81cf0a000097c34c DE-627 ger DE-627 rakwb rus QR1-502 Guzel S. Isaeva verfasserin aut Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. streptococcus pneumoniae bacterial carrier serotypes sequence types Microbiology Albina Z. Zaripova verfasserin aut Lira T. Bayazitova verfasserin aut Ralina M. Khusainova verfasserin aut Tatiana A. Chazova verfasserin aut Olga F. Tyupkina verfasserin aut Ekaterina V. Nikitina verfasserin aut Irina A. Tsvetkova verfasserin aut In Журнал микробиологии, эпидемиологии и иммунобиологии Central Research Institute for Epidemiology, 2020 101(2024), 1, Seite 89-99 (DE-627)1760649171 26867613 nnns volume:101 year:2024 number:1 pages:89-99 https://doi.org/10.36233/0372-9311-445 kostenfrei https://doaj.org/article/cf1ef4cfcfc74e4d81cf0a000097c34c kostenfrei https://microbiol.crie.ru/jour/article/viewFile/18556/1406 kostenfrei https://doaj.org/toc/0372-9311 Journal toc kostenfrei https://doaj.org/toc/2686-7613 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 101 2024 1 89-99 |
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Isaeva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. 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Guzel S. Isaeva Albina Z. Zaripova Lira T. Bayazitova Ralina M. Khusainova Tatiana A. Chazova Olga F. Tyupkina Ekaterina V. Nikitina Irina A. Tsvetkova |
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characteristics of <i<streptococcus pneumoniae</i< carriage in the pediatric population |
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Characteristics of <i<Streptococcus pneumoniae</i< carriage in the pediatric population |
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Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. |
| abstractGer |
Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. |
| abstract_unstemmed |
Objective: to investigate the regional peculiarities of Streptococcus pneumoniae carriage in the pediatric population and characterize the dominant serotypes of the pathogen. Materials and methods. The clinical study group consisted of 509 healthy children attending preschool institutions. Examination of nasopharyngeal samples for the detection of S. pneumonae was carried out by classical bacteriological and molecular biological methods. The serotype was determined by real-time PCR. Genome-wide sequencing of the serogroups 15 and 11 isolates and bioinformatic analysis were performed. Results. The S. pneumoniae bacterial carriers in the group of healthy children was detected in 207 children (40.7%), while the frequency of detection of S. pneumoniae in urban children living in Kazan was significantly higher than in children living in rural area and amounted to 53.4 and 31.1%, respectively (p 0.05). Among children vaccinated with the 13-valent pneumococcal conjugate vaccine (PCV-13), S. pneumoniae carriers were not detected in 57.5% of cases. There were no significant differences in the degree of nasopharyngeal contamination depending on the vaccination status. Analysis of the serotype composition indicates the predominance of vaccine serotypes (57.7%), while the share of serotypes included in the PСV-13 vaccine accounts for only 24.7%, the share of non-vaccine serotypes was 32.1%, untyped — 10.2%. In unvaccinated children, vaccine serotypes that are part of the PCV-13 and 23-valent polysaccharide pneumococcal vaccine prevailed (PPSV-23): 6ABCD (21%), 11 AD (15%), 14 (13%). In vaccinated children, serotypes not included in the active vaccines dominated: 15AF (17.4%), 23A (19.2%), as well as 11AD (19.6%) (11А is included in PPSV-23). The 27 Kz isolate (serotype 15C) belonged to one of the most common sequence types ST1025. The 105_Kz isolate (serotype 11D) belonged to another common sequence type ST 62. Conclusion. In order to improve epidemiological surveillance of pneumococcal infection, it is necessary to introduce the monitoring of circulating clonal complexes of dominant S. pneumoniae serogroups and analyze the genetic determinants of antibiotic resistance and virulence depending on the sequence type. |
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