The usage and advantages of several common amyotrophic lateral sclerosis animal models

Amyotrophic lateral sclerosis is a fatal, multigenic, multifactorial neurodegenerative disease characterized by upper and lower motor neuron loss. Animal models are essential for investigating pathogenesis and reflecting clinical manifestations, particularly in developing reasonable prevention and t...
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Autor*in:	Lijun Zhou [verfasserIn] Meng Xie [verfasserIn] Xinxin Wang [verfasserIn] Renshi Xu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	amyotrophic lateral sclerosis animal models motor neuron degeneration pathology pathogenesis

Übergeordnetes Werk:	In: Frontiers in Neuroscience - Frontiers Media S.A., 2008, 18(2024)
Übergeordnetes Werk:	volume:18 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnins.2024.1341109

Katalog-ID:	DOAJ091400732

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language	English
source	In Frontiers in Neuroscience 18(2024) volume:18 year:2024
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topic_facet	amyotrophic lateral sclerosis animal models motor neuron degeneration pathology pathogenesis Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Neuroscience
authorswithroles_txt_mv	Lijun Zhou @@aut@@ Meng Xie @@aut@@ Xinxin Wang @@aut@@ Renshi Xu @@aut@@
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callnumber-first	R - Medicine
author	Lijun Zhou
spellingShingle	Lijun Zhou misc RC321-571 misc amyotrophic lateral sclerosis misc animal models misc motor neuron degeneration misc pathology misc pathogenesis misc Neurosciences. Biological psychiatry. Neuropsychiatry The usage and advantages of several common amyotrophic lateral sclerosis animal models
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topic_title	RC321-571 The usage and advantages of several common amyotrophic lateral sclerosis animal models amyotrophic lateral sclerosis animal models motor neuron degeneration pathology pathogenesis
topic	misc RC321-571 misc amyotrophic lateral sclerosis misc animal models misc motor neuron degeneration misc pathology misc pathogenesis misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc amyotrophic lateral sclerosis misc animal models misc motor neuron degeneration misc pathology misc pathogenesis misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	The usage and advantages of several common amyotrophic lateral sclerosis animal models
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title_full	The usage and advantages of several common amyotrophic lateral sclerosis animal models
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title_sort	usage and advantages of several common amyotrophic lateral sclerosis animal models
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title_auth	The usage and advantages of several common amyotrophic lateral sclerosis animal models
abstract	Amyotrophic lateral sclerosis is a fatal, multigenic, multifactorial neurodegenerative disease characterized by upper and lower motor neuron loss. Animal models are essential for investigating pathogenesis and reflecting clinical manifestations, particularly in developing reasonable prevention and therapeutic methods for human diseases. Over the decades, researchers have established a host of different animal models in order to dissect amyotrophic lateral sclerosis (ALS), such as yeast, worms, flies, zebrafish, mice, rats, pigs, dogs, and more recently, non-human primates. Although these models show different peculiarities, they are all useful and complementary to dissect the pathological mechanisms of motor neuron degeneration in ALS, contributing to the development of new promising therapeutics. In this review, we describe several common animal models in ALS, classified by the naturally occurring and experimentally induced, pointing out their features in modeling, the onset and progression of the pathology, and their specific pathological hallmarks. Moreover, we highlight the pros and cons aimed at helping the researcher select the most appropriate among those common experimental animal models when designing a preclinical ALS study.
abstractGer	Amyotrophic lateral sclerosis is a fatal, multigenic, multifactorial neurodegenerative disease characterized by upper and lower motor neuron loss. Animal models are essential for investigating pathogenesis and reflecting clinical manifestations, particularly in developing reasonable prevention and therapeutic methods for human diseases. Over the decades, researchers have established a host of different animal models in order to dissect amyotrophic lateral sclerosis (ALS), such as yeast, worms, flies, zebrafish, mice, rats, pigs, dogs, and more recently, non-human primates. Although these models show different peculiarities, they are all useful and complementary to dissect the pathological mechanisms of motor neuron degeneration in ALS, contributing to the development of new promising therapeutics. In this review, we describe several common animal models in ALS, classified by the naturally occurring and experimentally induced, pointing out their features in modeling, the onset and progression of the pathology, and their specific pathological hallmarks. Moreover, we highlight the pros and cons aimed at helping the researcher select the most appropriate among those common experimental animal models when designing a preclinical ALS study.
abstract_unstemmed	Amyotrophic lateral sclerosis is a fatal, multigenic, multifactorial neurodegenerative disease characterized by upper and lower motor neuron loss. Animal models are essential for investigating pathogenesis and reflecting clinical manifestations, particularly in developing reasonable prevention and therapeutic methods for human diseases. Over the decades, researchers have established a host of different animal models in order to dissect amyotrophic lateral sclerosis (ALS), such as yeast, worms, flies, zebrafish, mice, rats, pigs, dogs, and more recently, non-human primates. Although these models show different peculiarities, they are all useful and complementary to dissect the pathological mechanisms of motor neuron degeneration in ALS, contributing to the development of new promising therapeutics. In this review, we describe several common animal models in ALS, classified by the naturally occurring and experimentally induced, pointing out their features in modeling, the onset and progression of the pathology, and their specific pathological hallmarks. Moreover, we highlight the pros and cons aimed at helping the researcher select the most appropriate among those common experimental animal models when designing a preclinical ALS study.
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title_short	The usage and advantages of several common amyotrophic lateral sclerosis animal models
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The usage and advantages of several common amyotrophic lateral sclerosis animal models

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