Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families

Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and difference...
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Autor*in:	Almudena Ramírez‐Martín [verfasserIn] Lea Sirignano [verfasserIn] Fabian Streit [verfasserIn] Jerome C. Foo [verfasserIn] Andreas J. Forstner [verfasserIn] Josef Frank [verfasserIn] Markus M. Nöthen [verfasserIn] Jana Strohmaier [verfasserIn] Stephanie H. Witt [verfasserIn] Fermin Mayoral‐Cleries [verfasserIn] Berta Moreno‐Küstner [verfasserIn] Marcella Rietschel [verfasserIn] Jose Guzmán‐Parra [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior

Übergeordnetes Werk:	In: Brain and Behavior - Wiley, 2012, 14(2024), 2, Seite n/a-n/a
Übergeordnetes Werk:	volume:14 ; year:2024 ; number:2 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/brb3.3337

Katalog-ID:	DOAJ091695228

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520			\|a Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders.
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700	0		\|a Marcella Rietschel \|e verfasserin \|4 aut
700	0		\|a Jose Guzmán‐Parra \|e verfasserin \|4 aut
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allfields	10.1002/brb3.3337 doi (DE-627)DOAJ091695228 (DE-599)DOAJ66ca129d2de447c3894f0b79beb211c1 DE-627 ger DE-627 rakwb eng RC321-571 Almudena Ramírez‐Martín verfasserin aut Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders. bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior Neurosciences. Biological psychiatry. Neuropsychiatry Lea Sirignano verfasserin aut Fabian Streit verfasserin aut Jerome C. Foo verfasserin aut Andreas J. Forstner verfasserin aut Josef Frank verfasserin aut Markus M. Nöthen verfasserin aut Jana Strohmaier verfasserin aut Stephanie H. Witt verfasserin aut Fermin Mayoral‐Cleries verfasserin aut Berta Moreno‐Küstner verfasserin aut Marcella Rietschel verfasserin aut Jose Guzmán‐Parra verfasserin aut In Brain and Behavior Wiley, 2012 14(2024), 2, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:14 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/article/66ca129d2de447c3894f0b79beb211c1 kostenfrei https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 2 n/a-n/a
spelling	10.1002/brb3.3337 doi (DE-627)DOAJ091695228 (DE-599)DOAJ66ca129d2de447c3894f0b79beb211c1 DE-627 ger DE-627 rakwb eng RC321-571 Almudena Ramírez‐Martín verfasserin aut Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders. bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior Neurosciences. Biological psychiatry. Neuropsychiatry Lea Sirignano verfasserin aut Fabian Streit verfasserin aut Jerome C. Foo verfasserin aut Andreas J. Forstner verfasserin aut Josef Frank verfasserin aut Markus M. Nöthen verfasserin aut Jana Strohmaier verfasserin aut Stephanie H. Witt verfasserin aut Fermin Mayoral‐Cleries verfasserin aut Berta Moreno‐Küstner verfasserin aut Marcella Rietschel verfasserin aut Jose Guzmán‐Parra verfasserin aut In Brain and Behavior Wiley, 2012 14(2024), 2, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:14 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/article/66ca129d2de447c3894f0b79beb211c1 kostenfrei https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 2 n/a-n/a
allfields_unstemmed	10.1002/brb3.3337 doi (DE-627)DOAJ091695228 (DE-599)DOAJ66ca129d2de447c3894f0b79beb211c1 DE-627 ger DE-627 rakwb eng RC321-571 Almudena Ramírez‐Martín verfasserin aut Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders. bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior Neurosciences. Biological psychiatry. Neuropsychiatry Lea Sirignano verfasserin aut Fabian Streit verfasserin aut Jerome C. Foo verfasserin aut Andreas J. Forstner verfasserin aut Josef Frank verfasserin aut Markus M. Nöthen verfasserin aut Jana Strohmaier verfasserin aut Stephanie H. Witt verfasserin aut Fermin Mayoral‐Cleries verfasserin aut Berta Moreno‐Küstner verfasserin aut Marcella Rietschel verfasserin aut Jose Guzmán‐Parra verfasserin aut In Brain and Behavior Wiley, 2012 14(2024), 2, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:14 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/article/66ca129d2de447c3894f0b79beb211c1 kostenfrei https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 2 n/a-n/a
allfieldsGer	10.1002/brb3.3337 doi (DE-627)DOAJ091695228 (DE-599)DOAJ66ca129d2de447c3894f0b79beb211c1 DE-627 ger DE-627 rakwb eng RC321-571 Almudena Ramírez‐Martín verfasserin aut Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders. bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior Neurosciences. Biological psychiatry. Neuropsychiatry Lea Sirignano verfasserin aut Fabian Streit verfasserin aut Jerome C. Foo verfasserin aut Andreas J. Forstner verfasserin aut Josef Frank verfasserin aut Markus M. Nöthen verfasserin aut Jana Strohmaier verfasserin aut Stephanie H. Witt verfasserin aut Fermin Mayoral‐Cleries verfasserin aut Berta Moreno‐Küstner verfasserin aut Marcella Rietschel verfasserin aut Jose Guzmán‐Parra verfasserin aut In Brain and Behavior Wiley, 2012 14(2024), 2, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:14 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/article/66ca129d2de447c3894f0b79beb211c1 kostenfrei https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 2 n/a-n/a
allfieldsSound	10.1002/brb3.3337 doi (DE-627)DOAJ091695228 (DE-599)DOAJ66ca129d2de447c3894f0b79beb211c1 DE-627 ger DE-627 rakwb eng RC321-571 Almudena Ramírez‐Martín verfasserin aut Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders. bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior Neurosciences. Biological psychiatry. Neuropsychiatry Lea Sirignano verfasserin aut Fabian Streit verfasserin aut Jerome C. Foo verfasserin aut Andreas J. Forstner verfasserin aut Josef Frank verfasserin aut Markus M. Nöthen verfasserin aut Jana Strohmaier verfasserin aut Stephanie H. Witt verfasserin aut Fermin Mayoral‐Cleries verfasserin aut Berta Moreno‐Küstner verfasserin aut Marcella Rietschel verfasserin aut Jose Guzmán‐Parra verfasserin aut In Brain and Behavior Wiley, 2012 14(2024), 2, Seite n/a-n/a (DE-627)66684805X (DE-600)2623587-0 21623279 nnns volume:14 year:2024 number:2 pages:n/a-n/a https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/article/66ca129d2de447c3894f0b79beb211c1 kostenfrei https://doi.org/10.1002/brb3.3337 kostenfrei https://doaj.org/toc/2162-3279 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 2 n/a-n/a
language	English
source	In Brain and Behavior 14(2024), 2, Seite n/a-n/a volume:14 year:2024 number:2 pages:n/a-n/a
sourceStr	In Brain and Behavior 14(2024), 2, Seite n/a-n/a volume:14 year:2024 number:2 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Brain and Behavior
authorswithroles_txt_mv	Almudena Ramírez‐Martín @@aut@@ Lea Sirignano @@aut@@ Fabian Streit @@aut@@ Jerome C. Foo @@aut@@ Andreas J. Forstner @@aut@@ Josef Frank @@aut@@ Markus M. Nöthen @@aut@@ Jana Strohmaier @@aut@@ Stephanie H. Witt @@aut@@ Fermin Mayoral‐Cleries @@aut@@ Berta Moreno‐Küstner @@aut@@ Marcella Rietschel @@aut@@ Jose Guzmán‐Parra @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	66684805X
id	DOAJ091695228
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ091695228</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240412101722.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240412s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/brb3.3337</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ091695228</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ66ca129d2de447c3894f0b79beb211c1</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC321-571</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Almudena Ramírez‐Martín</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. 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callnumber-first	R - Medicine
author	Almudena Ramírez‐Martín
spellingShingle	Almudena Ramírez‐Martín misc RC321-571 misc bipolar disorder misc bipolar multiplex families misc decision‐making misc impulsivity misc major depression disorder misc risk behavior misc Neurosciences. Biological psychiatry. Neuropsychiatry Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families
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topic_title	RC321-571 Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families bipolar disorder bipolar multiplex families decision‐making impulsivity major depression disorder risk behavior
topic	misc RC321-571 misc bipolar disorder misc bipolar multiplex families misc decision‐making misc impulsivity misc major depression disorder misc risk behavior misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc bipolar disorder misc bipolar multiplex families misc decision‐making misc impulsivity misc major depression disorder misc risk behavior misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families
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title_full	Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families
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author_browse	Almudena Ramírez‐Martín Lea Sirignano Fabian Streit Jerome C. Foo Andreas J. Forstner Josef Frank Markus M. Nöthen Jana Strohmaier Stephanie H. Witt Fermin Mayoral‐Cleries Berta Moreno‐Küstner Marcella Rietschel Jose Guzmán‐Parra
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title_sort	impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families
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title_auth	Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families
abstract	Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders.
abstractGer	Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders.
abstract_unstemmed	Abstract Objectives Bipolar disorder (BD) and major depressive disorder (MDD) are characterized by specific alterations of mood. In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. This underscores the importance of assessing such domains in addition to mere diagnosis of mood disorders.
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title_short	Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families
url	https://doi.org/10.1002/brb3.3337 https://doaj.org/article/66ca129d2de447c3894f0b79beb211c1 https://doaj.org/toc/2162-3279
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author2	Lea Sirignano Fabian Streit Jerome C. Foo Andreas J. Forstner Josef Frank Markus M. Nöthen Jana Strohmaier Stephanie H. Witt Fermin Mayoral‐Cleries Berta Moreno‐Küstner Marcella Rietschel Jose Guzmán‐Parra
author2Str	Lea Sirignano Fabian Streit Jerome C. Foo Andreas J. Forstner Josef Frank Markus M. Nöthen Jana Strohmaier Stephanie H. Witt Fermin Mayoral‐Cleries Berta Moreno‐Küstner Marcella Rietschel Jose Guzmán‐Parra
ppnlink	66684805X
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doi_str	10.1002/brb3.3337
callnumber-a	RC321-571
up_date	2024-07-03T21:43:23.669Z
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In both disorders, alterations in cognitive domains such as impulsivity, decision‐making, and risk‐taking have been reported. Identification of similarities and differences of these domains in BD and MDD could give further insight into their etiology. The present study assessed impulsivity, decision‐making, and risk‐taking behavior in BD and MDD patients from bipolar multiplex families. Methods Eighty‐two participants (BD type I, n = 25; MDD, n = 26; healthy relatives (HR), n = 17; and healthy controls (HC), n = 14) underwent diagnostic interviews and selected tests of a cognitive battery assessing neurocognitive performance across multiple subdomains including impulsivity (response inhibition and delay aversion), decision‐making, and risk behavior. Generalized estimating equations (GEEs) were used to analyze whether the groups differed in the respective cognitive domains. Results Participants with BD and MDD showed higher impulsivity levels compared to HC; this difference was more pronounced in BD participants. BD participants also showed lower inhibitory control than MDD participants. Overall, suboptimal decision‐making was associated with both mood disorders (BD and MDD). In risk‐taking behavior, no significant impairment was found in any group. Limitations As sample size was limited, it is possible that differences between BD and MDD may have escaped detection due to lack of statistical power. Conclusions Our findings show that alterations of cognitive domains—while present in both disorders—are differently associated with BD and MDD. 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Impulsivity, decision‐making, and risk behavior in bipolar disorder and major depression from bipolar multiplex families

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