Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study
Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of r...
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2023 |
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In: RUHS Journal of Health Sciences - Sonali Sharma on behalf of Rajasthan University of Health Sciences, 2023, (2023) |
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DOAJ091824265 |
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| 520 | |a Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu | ||
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(DE-627)DOAJ091824265 (DE-599)DOAJ8fef147c621140f6aade3fa3fa8bb7df DE-627 ger DE-627 rakwb eng Priyanka M Agrawal; Chanchal S Bherwani; Dnyaneshwari Gujar; Amit P Thareja; Nilima M Landge; Darshana Dalaya; Setu Mathur; Amit Chaudhari verfasserin aut Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu Not available Medicine R In RUHS Journal of Health Sciences Sonali Sharma on behalf of Rajasthan University of Health Sciences, 2023 (2023) (DE-627)1845703944 25823590 nnns year:2023 http://dx.doi.org/10.37821/ruhsjhs.2.2.2017.71-76 kostenfrei https://doaj.org/article/8fef147c621140f6aade3fa3fa8bb7df kostenfrei https://ruhsjhs.in/articleDetails.php?artid=TWpNNQ== kostenfrei https://doaj.org/toc/2456-8309 Journal toc kostenfrei https://doaj.org/toc/2582-3590 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 |
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(DE-627)DOAJ091824265 (DE-599)DOAJ8fef147c621140f6aade3fa3fa8bb7df DE-627 ger DE-627 rakwb eng Priyanka M Agrawal; Chanchal S Bherwani; Dnyaneshwari Gujar; Amit P Thareja; Nilima M Landge; Darshana Dalaya; Setu Mathur; Amit Chaudhari verfasserin aut Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu Not available Medicine R In RUHS Journal of Health Sciences Sonali Sharma on behalf of Rajasthan University of Health Sciences, 2023 (2023) (DE-627)1845703944 25823590 nnns year:2023 http://dx.doi.org/10.37821/ruhsjhs.2.2.2017.71-76 kostenfrei https://doaj.org/article/8fef147c621140f6aade3fa3fa8bb7df kostenfrei https://ruhsjhs.in/articleDetails.php?artid=TWpNNQ== kostenfrei https://doaj.org/toc/2456-8309 Journal toc kostenfrei https://doaj.org/toc/2582-3590 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 |
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(DE-627)DOAJ091824265 (DE-599)DOAJ8fef147c621140f6aade3fa3fa8bb7df DE-627 ger DE-627 rakwb eng Priyanka M Agrawal; Chanchal S Bherwani; Dnyaneshwari Gujar; Amit P Thareja; Nilima M Landge; Darshana Dalaya; Setu Mathur; Amit Chaudhari verfasserin aut Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu Not available Medicine R In RUHS Journal of Health Sciences Sonali Sharma on behalf of Rajasthan University of Health Sciences, 2023 (2023) (DE-627)1845703944 25823590 nnns year:2023 http://dx.doi.org/10.37821/ruhsjhs.2.2.2017.71-76 kostenfrei https://doaj.org/article/8fef147c621140f6aade3fa3fa8bb7df kostenfrei https://ruhsjhs.in/articleDetails.php?artid=TWpNNQ== kostenfrei https://doaj.org/toc/2456-8309 Journal toc kostenfrei https://doaj.org/toc/2582-3590 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 |
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(DE-627)DOAJ091824265 (DE-599)DOAJ8fef147c621140f6aade3fa3fa8bb7df DE-627 ger DE-627 rakwb eng Priyanka M Agrawal; Chanchal S Bherwani; Dnyaneshwari Gujar; Amit P Thareja; Nilima M Landge; Darshana Dalaya; Setu Mathur; Amit Chaudhari verfasserin aut Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu Not available Medicine R In RUHS Journal of Health Sciences Sonali Sharma on behalf of Rajasthan University of Health Sciences, 2023 (2023) (DE-627)1845703944 25823590 nnns year:2023 http://dx.doi.org/10.37821/ruhsjhs.2.2.2017.71-76 kostenfrei https://doaj.org/article/8fef147c621140f6aade3fa3fa8bb7df kostenfrei https://ruhsjhs.in/articleDetails.php?artid=TWpNNQ== kostenfrei https://doaj.org/toc/2456-8309 Journal toc kostenfrei https://doaj.org/toc/2582-3590 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 |
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(DE-627)DOAJ091824265 (DE-599)DOAJ8fef147c621140f6aade3fa3fa8bb7df DE-627 ger DE-627 rakwb eng Priyanka M Agrawal; Chanchal S Bherwani; Dnyaneshwari Gujar; Amit P Thareja; Nilima M Landge; Darshana Dalaya; Setu Mathur; Amit Chaudhari verfasserin aut Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu Not available Medicine R In RUHS Journal of Health Sciences Sonali Sharma on behalf of Rajasthan University of Health Sciences, 2023 (2023) (DE-627)1845703944 25823590 nnns year:2023 http://dx.doi.org/10.37821/ruhsjhs.2.2.2017.71-76 kostenfrei https://doaj.org/article/8fef147c621140f6aade3fa3fa8bb7df kostenfrei https://ruhsjhs.in/articleDetails.php?artid=TWpNNQ== kostenfrei https://doaj.org/toc/2456-8309 Journal toc kostenfrei https://doaj.org/toc/2582-3590 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2023 |
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Priyanka M Agrawal; Chanchal S Bherwani; Dnyaneshwari Gujar; Amit P Thareja; Nilima M Landge; Darshana Dalaya; Setu Mathur; Amit Chaudhari |
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Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study |
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assessment of neutrophil chemotaxis, phagocytosis and specific granule release in aggressive and chronic periodontitis patients: an in-vitro study |
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Assessment of Neutrophil Chemotaxis, Phagocytosis and Specific Granule Release in Aggressive and Chronic Periodontitis Patients: An In-Vitro Study |
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Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu |
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Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu |
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Introduction: Neutrophils are responsible for immunologically induced tissue injury. When normal regulatory mechanisms fail, following activation by bacterial by-products or other immune stimuli, neutrophils execute several specialized functions that include chemotaxis, phagocytosis, generation of reactive oxygen metabolites and specific granule release. The important role polymorphonuclear neutrophils (PMNs) play in optimal functioning of the immune defense system has led to speculation that a partly compromised system could severely weaken the defense mounted against a bacterial insult and permit the occurrence and progression of infections. The study was aimed to assess neutrophil function i.e. chemotaxis, phagocytosis and specific granule release in patients with aggressive and chronic periodontitis in Indian population. Methodology: 60 patients with age group varying between 13-60 years from both sex were selected and were divided into three groups: Group I — 20 Generalized Aggressive Periodontitis subjects (GAgP), Group II — 20 Generalized Chronic Periodontitis subjects (CP), Group III — 20 Control Group of periodontally healthy subjects. Venous blood samples were collected and various neutrophil functions viz. chemotaxis, phagocytosis and specific granule release were carried out using different assays such as N-Formylmethionyl-leucyl-phenylalanine (FMLP), Candidia albicans suspension, Nitroblue tetrazolium test (NBT). Results: The results of the study suggest that chemotaxis was significantly reduced in generalised aggressive periodontitis patients as compared to chronic periodontitis and periodontally healthy subjects. GAgP and CP patients showed no significant difference in phagocytosis rate as compared to periodontally healthy control group. Unstimulated NBT reduction is increased in neutrophils from patients with infection and the intracellular killing capacity of neutrophils is reduced in GAgP and CP patients. Conclusion: The assessment of neutrophil fu |
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| score |
7.398241 |