Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women

Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or r...
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Autor*in:	Stacy Selke [verfasserIn] Anna Wald [verfasserIn] Alison Roxby [verfasserIn] Kenneth Ngure [verfasserIn] Nelly Mugo [verfasserIn] Lynda Oluoch [verfasserIn] Bhavna Chohan [verfasserIn] Catherine Kiptinness [verfasserIn] Kenneth Tapia [verfasserIn] Stephen Gakuo Maina [verfasserIn] Edinah Casmir [verfasserIn] L Makena [verfasserIn] Melody Wang [verfasserIn] Laura Sycuro [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	In: BMJ Open - BMJ Publishing Group, 2011, 13(2023), 10
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1136/bmjopen-2023-071746

Katalog-ID:	DOAJ091855497

Internformat


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041			\|a eng
100	0		\|a Stacy Selke \|e verfasserin \|4 aut
245	1	0	\|a Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women
264		1	\|c 2023
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV.
653		0	\|a Medicine
653		0	\|a R
700	0		\|a Anna Wald \|e verfasserin \|4 aut
700	0		\|a Alison Roxby \|e verfasserin \|4 aut
700	0		\|a Kenneth Ngure \|e verfasserin \|4 aut
700	0		\|a Nelly Mugo \|e verfasserin \|4 aut
700	0		\|a Lynda Oluoch \|e verfasserin \|4 aut
700	0		\|a Bhavna Chohan \|e verfasserin \|4 aut
700	0		\|a Catherine Kiptinness \|e verfasserin \|4 aut
700	0		\|a Kenneth Tapia \|e verfasserin \|4 aut
700	0		\|a Stephen Gakuo Maina \|e verfasserin \|4 aut
700	0		\|a Edinah Casmir \|e verfasserin \|4 aut
700	0		\|a L Makena \|e verfasserin \|4 aut
700	0		\|a Melody Wang \|e verfasserin \|4 aut
700	0		\|a Laura Sycuro \|e verfasserin \|4 aut
773	0	8	\|i In \|t BMJ Open \|d BMJ Publishing Group, 2011 \|g 13(2023), 10 \|w (DE-627)654747075 \|w (DE-600)2599832-8 \|x 20446055 \|7 nnns
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912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_375
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 13 \|j 2023 \|e 10

Indexfelder

author_variant	s s ss a w aw a r ar k n kn n m nm l o lo b c bc c k ck k t kt s g m sgm e c ec l m lm m w mw l s ls
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publishDate	2023
allfields	10.1136/bmjopen-2023-071746 doi (DE-627)DOAJ091855497 (DE-599)DOAJ055110a1d24c4a53afad237736617527 DE-627 ger DE-627 rakwb eng Stacy Selke verfasserin aut Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV. Medicine R Anna Wald verfasserin aut Alison Roxby verfasserin aut Kenneth Ngure verfasserin aut Nelly Mugo verfasserin aut Lynda Oluoch verfasserin aut Bhavna Chohan verfasserin aut Catherine Kiptinness verfasserin aut Kenneth Tapia verfasserin aut Stephen Gakuo Maina verfasserin aut Edinah Casmir verfasserin aut L Makena verfasserin aut Melody Wang verfasserin aut Laura Sycuro verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2023-071746 kostenfrei https://doaj.org/article/055110a1d24c4a53afad237736617527 kostenfrei https://bmjopen.bmj.com/content/13/10/e071746.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10
spelling	10.1136/bmjopen-2023-071746 doi (DE-627)DOAJ091855497 (DE-599)DOAJ055110a1d24c4a53afad237736617527 DE-627 ger DE-627 rakwb eng Stacy Selke verfasserin aut Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV. Medicine R Anna Wald verfasserin aut Alison Roxby verfasserin aut Kenneth Ngure verfasserin aut Nelly Mugo verfasserin aut Lynda Oluoch verfasserin aut Bhavna Chohan verfasserin aut Catherine Kiptinness verfasserin aut Kenneth Tapia verfasserin aut Stephen Gakuo Maina verfasserin aut Edinah Casmir verfasserin aut L Makena verfasserin aut Melody Wang verfasserin aut Laura Sycuro verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2023-071746 kostenfrei https://doaj.org/article/055110a1d24c4a53afad237736617527 kostenfrei https://bmjopen.bmj.com/content/13/10/e071746.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10
allfields_unstemmed	10.1136/bmjopen-2023-071746 doi (DE-627)DOAJ091855497 (DE-599)DOAJ055110a1d24c4a53afad237736617527 DE-627 ger DE-627 rakwb eng Stacy Selke verfasserin aut Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV. Medicine R Anna Wald verfasserin aut Alison Roxby verfasserin aut Kenneth Ngure verfasserin aut Nelly Mugo verfasserin aut Lynda Oluoch verfasserin aut Bhavna Chohan verfasserin aut Catherine Kiptinness verfasserin aut Kenneth Tapia verfasserin aut Stephen Gakuo Maina verfasserin aut Edinah Casmir verfasserin aut L Makena verfasserin aut Melody Wang verfasserin aut Laura Sycuro verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2023-071746 kostenfrei https://doaj.org/article/055110a1d24c4a53afad237736617527 kostenfrei https://bmjopen.bmj.com/content/13/10/e071746.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10
allfieldsGer	10.1136/bmjopen-2023-071746 doi (DE-627)DOAJ091855497 (DE-599)DOAJ055110a1d24c4a53afad237736617527 DE-627 ger DE-627 rakwb eng Stacy Selke verfasserin aut Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV. Medicine R Anna Wald verfasserin aut Alison Roxby verfasserin aut Kenneth Ngure verfasserin aut Nelly Mugo verfasserin aut Lynda Oluoch verfasserin aut Bhavna Chohan verfasserin aut Catherine Kiptinness verfasserin aut Kenneth Tapia verfasserin aut Stephen Gakuo Maina verfasserin aut Edinah Casmir verfasserin aut L Makena verfasserin aut Melody Wang verfasserin aut Laura Sycuro verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2023-071746 kostenfrei https://doaj.org/article/055110a1d24c4a53afad237736617527 kostenfrei https://bmjopen.bmj.com/content/13/10/e071746.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10
allfieldsSound	10.1136/bmjopen-2023-071746 doi (DE-627)DOAJ091855497 (DE-599)DOAJ055110a1d24c4a53afad237736617527 DE-627 ger DE-627 rakwb eng Stacy Selke verfasserin aut Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV. Medicine R Anna Wald verfasserin aut Alison Roxby verfasserin aut Kenneth Ngure verfasserin aut Nelly Mugo verfasserin aut Lynda Oluoch verfasserin aut Bhavna Chohan verfasserin aut Catherine Kiptinness verfasserin aut Kenneth Tapia verfasserin aut Stephen Gakuo Maina verfasserin aut Edinah Casmir verfasserin aut L Makena verfasserin aut Melody Wang verfasserin aut Laura Sycuro verfasserin aut In BMJ Open BMJ Publishing Group, 2011 13(2023), 10 (DE-627)654747075 (DE-600)2599832-8 20446055 nnns volume:13 year:2023 number:10 https://doi.org/10.1136/bmjopen-2023-071746 kostenfrei https://doaj.org/article/055110a1d24c4a53afad237736617527 kostenfrei https://bmjopen.bmj.com/content/13/10/e071746.full kostenfrei https://doaj.org/toc/2044-6055 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 10
language	English
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authorswithroles_txt_mv	Stacy Selke @@aut@@ Anna Wald @@aut@@ Alison Roxby @@aut@@ Kenneth Ngure @@aut@@ Nelly Mugo @@aut@@ Lynda Oluoch @@aut@@ Bhavna Chohan @@aut@@ Catherine Kiptinness @@aut@@ Kenneth Tapia @@aut@@ Stephen Gakuo Maina @@aut@@ Edinah Casmir @@aut@@ L Makena @@aut@@ Melody Wang @@aut@@ Laura Sycuro @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
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author	Stacy Selke
spellingShingle	Stacy Selke misc Medicine misc R Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women
authorStr	Stacy Selke
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topic_title	Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women
topic	misc Medicine misc R
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title	Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women
ctrlnum	(DE-627)DOAJ091855497 (DE-599)DOAJ055110a1d24c4a53afad237736617527
title_full	Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women
author_sort	Stacy Selke
journal	BMJ Open
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lang_code	eng
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author_browse	Stacy Selke Anna Wald Alison Roxby Kenneth Ngure Nelly Mugo Lynda Oluoch Bhavna Chohan Catherine Kiptinness Kenneth Tapia Stephen Gakuo Maina Edinah Casmir L Makena Melody Wang Laura Sycuro
container_volume	13
format_se	Elektronische Aufsätze
author-letter	Stacy Selke
doi_str_mv	10.1136/bmjopen-2023-071746
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title_sort	longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in kenyan adolescent girls and young women
title_auth	Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women
abstract	Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV.
abstractGer	Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV.
abstract_unstemmed	Objective To determine bacterial vaginosis (BV) status at multiple time points among adolescent girls and young women (AGYW) and assess the impact of pregnancy on their BV status.Design Longitudinal cohort study.Setting Thika, Kenya.Participants AGYW aged 16–20 years enrolled prior to first sex or reporting only a single lifetime partner.Main outcome measures The primary outcome was relative risk (RR) of BV during pregnancy compared with before pregnancy by analysing longitudinal trends in BV over time. BV risk was estimated using Poisson regression models.Results A total of 121 AGYW became pregnant in the parent cohort and had BV results before, during or after pregnancy. Point prevalence of BV was 11.0% at visits >12 months pre-pregnancy, 13.0% at 3–12 months pre-pregnancy, 22.1% at <3 months pre-pregnancy and 13.4% during pregnancy. Compared with visits during pregnancy, RR of BV was 1.65 (95% CI: 1.00 to 2.71; p=0.05) at visits <3 months pre-pregnancy, 0.97 (95% CI: 0.62 to 1.52; p=0.90) at visits 3–12 months pre-pregnancy and 0.82 (95% CI: 0.44 to 1.53; p=0.53) at visits 12 months pre-pregnancy. An adjusted analysis including age, income, residence, date of first sex, recent sexual activity and positive sexually transmitted infection test resulted in small changes in risk estimates, with adjusted RR of BV of 1.66 (95% CI: 1.04 to 2.67; p=0.04) at visits <3 months pre-pregnancy compared with visits during pregnancy.Conclusions BV risk during pregnancy was lower than during the immediate pre-pregnancy period. Hormonal changes in pregnancy may reduce BV.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	10
title_short	Longitudinal assessment of bacterial vaginosis prior to and during incident pregnancy: an observational study in Kenyan adolescent girls and young women
url	https://doi.org/10.1136/bmjopen-2023-071746 https://doaj.org/article/055110a1d24c4a53afad237736617527 https://bmjopen.bmj.com/content/13/10/e071746.full https://doaj.org/toc/2044-6055
remote_bool	true
author2	Anna Wald Alison Roxby Kenneth Ngure Nelly Mugo Lynda Oluoch Bhavna Chohan Catherine Kiptinness Kenneth Tapia Stephen Gakuo Maina Edinah Casmir L Makena Melody Wang Laura Sycuro
author2Str	Anna Wald Alison Roxby Kenneth Ngure Nelly Mugo Lynda Oluoch Bhavna Chohan Catherine Kiptinness Kenneth Tapia Stephen Gakuo Maina Edinah Casmir L Makena Melody Wang Laura Sycuro
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doi_str	10.1136/bmjopen-2023-071746
up_date	2024-07-03T22:40:27.560Z
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