Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)

ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity o...
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Autor*in:	Naeem Rasool [verfasserIn] Muhammad Ovais Omer [verfasserIn] Aqeel Javeed [verfasserIn] Muhammad Nawaz [verfasserIn] Muhammad Adil Rasheed [verfasserIn] Muhammad Imran [verfasserIn] Muzzamal Hussain [verfasserIn] Amal Fahmy Dawood [verfasserIn] Zarina Mushtaq [verfasserIn] Entessar Al Jbawi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity

Übergeordnetes Werk:	In: International Journal of Food Properties - Taylor & Francis Group, 2018, 26(2023), 1, Seite 1457-1469
Übergeordnetes Werk:	volume:26 ; year:2023 ; number:1 ; pages:1457-1469

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/10942912.2023.2219859

Katalog-ID:	DOAJ091911370

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245	1	0	\|a Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)
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520			\|a ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml).
650		4	\|a Argyrolobium roseum (Camb.)
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650		4	\|a cytotoxicity
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653		0	\|a Nutrition. Foods and food supply
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700	0		\|a Muzzamal Hussain \|e verfasserin \|4 aut
700	0		\|a Amal Fahmy Dawood \|e verfasserin \|4 aut
700	0		\|a Zarina Mushtaq \|e verfasserin \|4 aut
700	0		\|a Entessar Al Jbawi \|e verfasserin \|4 aut
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allfields	10.1080/10942912.2023.2219859 doi (DE-627)DOAJ091911370 (DE-599)DOAJd765cf00e07b4cd39bd5efedecadd2e3 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Naeem Rasool verfasserin aut Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml). Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity Nutrition. Foods and food supply Food processing and manufacture Muhammad Ovais Omer verfasserin aut Aqeel Javeed verfasserin aut Muhammad Nawaz verfasserin aut Muhammad Adil Rasheed verfasserin aut Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Amal Fahmy Dawood verfasserin aut Zarina Mushtaq verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1457-1469 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1457-1469 https://doi.org/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/article/d765cf00e07b4cd39bd5efedecadd2e3 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1457-1469
spelling	10.1080/10942912.2023.2219859 doi (DE-627)DOAJ091911370 (DE-599)DOAJd765cf00e07b4cd39bd5efedecadd2e3 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Naeem Rasool verfasserin aut Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml). Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity Nutrition. Foods and food supply Food processing and manufacture Muhammad Ovais Omer verfasserin aut Aqeel Javeed verfasserin aut Muhammad Nawaz verfasserin aut Muhammad Adil Rasheed verfasserin aut Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Amal Fahmy Dawood verfasserin aut Zarina Mushtaq verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1457-1469 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1457-1469 https://doi.org/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/article/d765cf00e07b4cd39bd5efedecadd2e3 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1457-1469
allfields_unstemmed	10.1080/10942912.2023.2219859 doi (DE-627)DOAJ091911370 (DE-599)DOAJd765cf00e07b4cd39bd5efedecadd2e3 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Naeem Rasool verfasserin aut Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml). Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity Nutrition. Foods and food supply Food processing and manufacture Muhammad Ovais Omer verfasserin aut Aqeel Javeed verfasserin aut Muhammad Nawaz verfasserin aut Muhammad Adil Rasheed verfasserin aut Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Amal Fahmy Dawood verfasserin aut Zarina Mushtaq verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1457-1469 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1457-1469 https://doi.org/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/article/d765cf00e07b4cd39bd5efedecadd2e3 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1457-1469
allfieldsGer	10.1080/10942912.2023.2219859 doi (DE-627)DOAJ091911370 (DE-599)DOAJd765cf00e07b4cd39bd5efedecadd2e3 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Naeem Rasool verfasserin aut Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml). Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity Nutrition. Foods and food supply Food processing and manufacture Muhammad Ovais Omer verfasserin aut Aqeel Javeed verfasserin aut Muhammad Nawaz verfasserin aut Muhammad Adil Rasheed verfasserin aut Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Amal Fahmy Dawood verfasserin aut Zarina Mushtaq verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1457-1469 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1457-1469 https://doi.org/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/article/d765cf00e07b4cd39bd5efedecadd2e3 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1457-1469
allfieldsSound	10.1080/10942912.2023.2219859 doi (DE-627)DOAJ091911370 (DE-599)DOAJd765cf00e07b4cd39bd5efedecadd2e3 DE-627 ger DE-627 rakwb eng TX341-641 TP368-456 Naeem Rasool verfasserin aut Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml). Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity Nutrition. Foods and food supply Food processing and manufacture Muhammad Ovais Omer verfasserin aut Aqeel Javeed verfasserin aut Muhammad Nawaz verfasserin aut Muhammad Adil Rasheed verfasserin aut Muhammad Imran verfasserin aut Muzzamal Hussain verfasserin aut Amal Fahmy Dawood verfasserin aut Zarina Mushtaq verfasserin aut Entessar Al Jbawi verfasserin aut In International Journal of Food Properties Taylor & Francis Group, 2018 26(2023), 1, Seite 1457-1469 (DE-627)334376416 (DE-600)2057781-3 15322386 nnns volume:26 year:2023 number:1 pages:1457-1469 https://doi.org/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/article/d765cf00e07b4cd39bd5efedecadd2e3 kostenfrei https://www.tandfonline.com/doi/10.1080/10942912.2023.2219859 kostenfrei https://doaj.org/toc/1094-2912 Journal toc kostenfrei https://doaj.org/toc/1532-2386 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2023 1 1457-1469
language	English
source	In International Journal of Food Properties 26(2023), 1, Seite 1457-1469 volume:26 year:2023 number:1 pages:1457-1469
sourceStr	In International Journal of Food Properties 26(2023), 1, Seite 1457-1469 volume:26 year:2023 number:1 pages:1457-1469
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity Nutrition. Foods and food supply Food processing and manufacture
isfreeaccess_bool	true
container_title	International Journal of Food Properties
authorswithroles_txt_mv	Naeem Rasool @@aut@@ Muhammad Ovais Omer @@aut@@ Aqeel Javeed @@aut@@ Muhammad Nawaz @@aut@@ Muhammad Adil Rasheed @@aut@@ Muhammad Imran @@aut@@ Muzzamal Hussain @@aut@@ Amal Fahmy Dawood @@aut@@ Zarina Mushtaq @@aut@@ Entessar Al Jbawi @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	334376416
id	DOAJ091911370
language_de	englisch
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The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. 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callnumber-first	T - Technology
author	Naeem Rasool
spellingShingle	Naeem Rasool misc TX341-641 misc TP368-456 misc Argyrolobium roseum (Camb.) misc aqueous and ethanolic extract misc cytotoxicity misc genotoxicity misc mutagenicity misc Nutrition. Foods and food supply misc Food processing and manufacture Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)
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topic_title	TX341-641 TP368-456 Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.) Argyrolobium roseum (Camb.) aqueous and ethanolic extract cytotoxicity genotoxicity mutagenicity
topic	misc TX341-641 misc TP368-456 misc Argyrolobium roseum (Camb.) misc aqueous and ethanolic extract misc cytotoxicity misc genotoxicity misc mutagenicity misc Nutrition. Foods and food supply misc Food processing and manufacture
topic_unstemmed	misc TX341-641 misc TP368-456 misc Argyrolobium roseum (Camb.) misc aqueous and ethanolic extract misc cytotoxicity misc genotoxicity misc mutagenicity misc Nutrition. Foods and food supply misc Food processing and manufacture
topic_browse	misc TX341-641 misc TP368-456 misc Argyrolobium roseum (Camb.) misc aqueous and ethanolic extract misc cytotoxicity misc genotoxicity misc mutagenicity misc Nutrition. Foods and food supply misc Food processing and manufacture
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title	Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)
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title_full	Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)
author_sort	Naeem Rasool
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author_browse	Naeem Rasool Muhammad Ovais Omer Aqeel Javeed Muhammad Nawaz Muhammad Adil Rasheed Muhammad Imran Muzzamal Hussain Amal Fahmy Dawood Zarina Mushtaq Entessar Al Jbawi
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doi_str_mv	10.1080/10942912.2023.2219859
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title_sort	phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of argyrolobium roseum (camb.)
callnumber	TX341-641
title_auth	Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)
abstract	ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml).
abstractGer	ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml).
abstract_unstemmed	ABSTRACTThe current study aimed to investigate the phenolic and flavonoid contents, cytotoxicity, genotoxicity, and mutagenicity of ethanolic and aqueous extracts of A. roseum (Camb.). The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml).
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title_short	Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)
url	https://doi.org/10.1080/10942912.2023.2219859 https://doaj.org/article/d765cf00e07b4cd39bd5efedecadd2e3 https://www.tandfonline.com/doi/10.1080/10942912.2023.2219859 https://doaj.org/toc/1094-2912 https://doaj.org/toc/1532-2386
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The MTT assay was used to determine cytotoxicity, Comet assay was used to determine genotoxicity and mutagenicity of extracts was assessed through Ames test. The results showed that total phenolic contents were higher in aqueous extract (538.26 mg GAE/100 g); however, total flavonoid contents were significantly higher in ethanolic extract (6553.29 mg Eq. of Quercetin/100 g). The cells survival percentage was significantly (P <.05) decreased as concentrations of ethanolic extract increased. However, no significant toxicity was observed in groups treated with 0.031–0.25 mg/ml of ethanolic extract of A. roseum compared to negative control (P < .05). IC50 of ethanolic and aqueous extract of A. roseum was 5.54 mg/ml and 11.39 mg/ml, respectively. The results indicated that all concentration groups of ethanolic and aqueous extract of A. roseum significantly (P < .05) lowered DNA damage than positive control group. The lowest DNA damage was observed at 0.031 and 0.062 mg/ml in both aqueous and ethanolic extracts. Moreover, at higher concentrations of 4, 8, and 16 mg/ml of both ethanolic and aqueous extract observed 100% DNA damage cells (comet cells). Moreover, Ames mutagenicity showed that no significant (P < .05) changes were observed in revertant colonies of both bacterial strains (T 98; T 100) at 0.25, 0.5, and 1 mg/ml concentrations of both aqueous and ethanolic extract of A. roseum as MI index was less than 2. The research concluded that A. roseum extracts exhibited no cytotoxicity, genotoxicity, and mutagenicity at lower concentrations (≤2 mg/ml).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Argyrolobium roseum (Camb.)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">aqueous and ethanolic extract</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cytotoxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">genotoxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mutagenicity</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Nutrition. Foods and food supply</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Food processing and manufacture</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Ovais Omer</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Aqeel Javeed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Nawaz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Adil Rasheed</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Muhammad Imran</subfield><subfield code="e">verfasserin</subfield><subfield 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Phytochemical properties and in-vitro cytotoxicity, genotoxicity and mutagenicity assessment of ethanolic and aqueous extracts of Argyrolobium roseum (Camb.)

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