Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis

Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resista...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Naomee Shareef [verfasserIn] Ahmed Abu Saleh [verfasserIn] Abu Naser Ibne Sattar [verfasserIn] Shaheda Anwar [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	MDR-TB, RIF resistance, INH resistance, katG, inhA

Übergeordnetes Werk:	In: Bangabandhu Sheikh Mujib Medical University Journal - Bangabandhu Sheikh Mujib Medical University, 2017, 16(2023), 3
Übergeordnetes Werk:	volume:16 ; year:2023 ; number:3

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3329/bsmmuj.v16i3.64496

Katalog-ID:	DOAJ09191289X

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ09191289X
003	DE-627
005	20240414194212.0
007	cr uuu---uuuuu
008	240412s2023 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3329/bsmmuj.v16i3.64496 \|2 doi
035			\|a (DE-627)DOAJ09191289X
035			\|a (DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	0		\|a Naomee Shareef \|e verfasserin \|4 aut
245	1	0	\|a Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis
264		1	\|c 2023
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166
650		4	\|a MDR-TB, RIF resistance, INH resistance, katG, inhA
653		0	\|a Medicine
653		0	\|a R
700	0		\|a Ahmed Abu Saleh \|e verfasserin \|4 aut
700	0		\|a Abu Naser Ibne Sattar \|e verfasserin \|4 aut
700	0		\|a Shaheda Anwar \|e verfasserin \|4 aut
773	0	8	\|i In \|t Bangabandhu Sheikh Mujib Medical University Journal \|d Bangabandhu Sheikh Mujib Medical University, 2017 \|g 16(2023), 3 \|w (DE-627)635605961 \|w (DE-600)2573885-9 \|x 22247750 \|7 nnns
773	1	8	\|g volume:16 \|g year:2023 \|g number:3
856	4	0	\|u https://doi.org/10.3329/bsmmuj.v16i3.64496 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e \|z kostenfrei
856	4	0	\|u https://banglajol.info/index.php/BSMMUJ/article/view/64496 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2074-2908 \|y Journal toc \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2224-7750 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 16 \|j 2023 \|e 3

Indexfelder

author_variant	n s ns a a s aas a n i s anis s a sa
matchkey_str	article:22247750:2023----::snairssacpoieniapcneitnmcbc
hierarchy_sort_str	2023
publishDate	2023
allfields	10.3329/bsmmuj.v16i3.64496 doi (DE-627)DOAJ09191289X (DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e DE-627 ger DE-627 rakwb eng Naomee Shareef verfasserin aut Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166 MDR-TB, RIF resistance, INH resistance, katG, inhA Medicine R Ahmed Abu Saleh verfasserin aut Abu Naser Ibne Sattar verfasserin aut Shaheda Anwar verfasserin aut In Bangabandhu Sheikh Mujib Medical University Journal Bangabandhu Sheikh Mujib Medical University, 2017 16(2023), 3 (DE-627)635605961 (DE-600)2573885-9 22247750 nnns volume:16 year:2023 number:3 https://doi.org/10.3329/bsmmuj.v16i3.64496 kostenfrei https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e kostenfrei https://banglajol.info/index.php/BSMMUJ/article/view/64496 kostenfrei https://doaj.org/toc/2074-2908 Journal toc kostenfrei https://doaj.org/toc/2224-7750 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 3
spelling	10.3329/bsmmuj.v16i3.64496 doi (DE-627)DOAJ09191289X (DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e DE-627 ger DE-627 rakwb eng Naomee Shareef verfasserin aut Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166 MDR-TB, RIF resistance, INH resistance, katG, inhA Medicine R Ahmed Abu Saleh verfasserin aut Abu Naser Ibne Sattar verfasserin aut Shaheda Anwar verfasserin aut In Bangabandhu Sheikh Mujib Medical University Journal Bangabandhu Sheikh Mujib Medical University, 2017 16(2023), 3 (DE-627)635605961 (DE-600)2573885-9 22247750 nnns volume:16 year:2023 number:3 https://doi.org/10.3329/bsmmuj.v16i3.64496 kostenfrei https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e kostenfrei https://banglajol.info/index.php/BSMMUJ/article/view/64496 kostenfrei https://doaj.org/toc/2074-2908 Journal toc kostenfrei https://doaj.org/toc/2224-7750 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 3
allfields_unstemmed	10.3329/bsmmuj.v16i3.64496 doi (DE-627)DOAJ09191289X (DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e DE-627 ger DE-627 rakwb eng Naomee Shareef verfasserin aut Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166 MDR-TB, RIF resistance, INH resistance, katG, inhA Medicine R Ahmed Abu Saleh verfasserin aut Abu Naser Ibne Sattar verfasserin aut Shaheda Anwar verfasserin aut In Bangabandhu Sheikh Mujib Medical University Journal Bangabandhu Sheikh Mujib Medical University, 2017 16(2023), 3 (DE-627)635605961 (DE-600)2573885-9 22247750 nnns volume:16 year:2023 number:3 https://doi.org/10.3329/bsmmuj.v16i3.64496 kostenfrei https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e kostenfrei https://banglajol.info/index.php/BSMMUJ/article/view/64496 kostenfrei https://doaj.org/toc/2074-2908 Journal toc kostenfrei https://doaj.org/toc/2224-7750 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 3
allfieldsGer	10.3329/bsmmuj.v16i3.64496 doi (DE-627)DOAJ09191289X (DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e DE-627 ger DE-627 rakwb eng Naomee Shareef verfasserin aut Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166 MDR-TB, RIF resistance, INH resistance, katG, inhA Medicine R Ahmed Abu Saleh verfasserin aut Abu Naser Ibne Sattar verfasserin aut Shaheda Anwar verfasserin aut In Bangabandhu Sheikh Mujib Medical University Journal Bangabandhu Sheikh Mujib Medical University, 2017 16(2023), 3 (DE-627)635605961 (DE-600)2573885-9 22247750 nnns volume:16 year:2023 number:3 https://doi.org/10.3329/bsmmuj.v16i3.64496 kostenfrei https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e kostenfrei https://banglajol.info/index.php/BSMMUJ/article/view/64496 kostenfrei https://doaj.org/toc/2074-2908 Journal toc kostenfrei https://doaj.org/toc/2224-7750 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 3
allfieldsSound	10.3329/bsmmuj.v16i3.64496 doi (DE-627)DOAJ09191289X (DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e DE-627 ger DE-627 rakwb eng Naomee Shareef verfasserin aut Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166 MDR-TB, RIF resistance, INH resistance, katG, inhA Medicine R Ahmed Abu Saleh verfasserin aut Abu Naser Ibne Sattar verfasserin aut Shaheda Anwar verfasserin aut In Bangabandhu Sheikh Mujib Medical University Journal Bangabandhu Sheikh Mujib Medical University, 2017 16(2023), 3 (DE-627)635605961 (DE-600)2573885-9 22247750 nnns volume:16 year:2023 number:3 https://doi.org/10.3329/bsmmuj.v16i3.64496 kostenfrei https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e kostenfrei https://banglajol.info/index.php/BSMMUJ/article/view/64496 kostenfrei https://doaj.org/toc/2074-2908 Journal toc kostenfrei https://doaj.org/toc/2224-7750 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2023 3
language	English
source	In Bangabandhu Sheikh Mujib Medical University Journal 16(2023), 3 volume:16 year:2023 number:3
sourceStr	In Bangabandhu Sheikh Mujib Medical University Journal 16(2023), 3 volume:16 year:2023 number:3
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	MDR-TB, RIF resistance, INH resistance, katG, inhA Medicine R
isfreeaccess_bool	true
container_title	Bangabandhu Sheikh Mujib Medical University Journal
authorswithroles_txt_mv	Naomee Shareef @@aut@@ Ahmed Abu Saleh @@aut@@ Abu Naser Ibne Sattar @@aut@@ Shaheda Anwar @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	635605961
id	DOAJ09191289X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ09191289X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414194212.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240412s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3329/bsmmuj.v16i3.64496</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ09191289X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Naomee Shareef</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166 </subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MDR-TB, RIF resistance, INH resistance, katG, inhA</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmed Abu Saleh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abu Naser Ibne Sattar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shaheda Anwar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Bangabandhu Sheikh Mujib Medical University Journal</subfield><subfield code="d">Bangabandhu Sheikh Mujib Medical University, 2017</subfield><subfield code="g">16(2023), 3</subfield><subfield code="w">(DE-627)635605961</subfield><subfield code="w">(DE-600)2573885-9</subfield><subfield code="x">22247750</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:16</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:3</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3329/bsmmuj.v16i3.64496</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://banglajol.info/index.php/BSMMUJ/article/view/64496</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2074-2908</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2224-7750</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">16</subfield><subfield code="j">2023</subfield><subfield code="e">3</subfield></datafield></record></collection>
author	Naomee Shareef
spellingShingle	Naomee Shareef misc MDR-TB, RIF resistance, INH resistance, katG, inhA misc Medicine misc R Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis
authorStr	Naomee Shareef
ppnlink_with_tag_str_mv	@@773@@(DE-627)635605961
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut
collection	DOAJ
remote_str	true
illustrated	Not Illustrated
issn	22247750
topic_title	Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis MDR-TB, RIF resistance, INH resistance, katG, inhA
topic	misc MDR-TB, RIF resistance, INH resistance, katG, inhA misc Medicine misc R
topic_unstemmed	misc MDR-TB, RIF resistance, INH resistance, katG, inhA misc Medicine misc R
topic_browse	misc MDR-TB, RIF resistance, INH resistance, katG, inhA misc Medicine misc R
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Bangabandhu Sheikh Mujib Medical University Journal
hierarchy_parent_id	635605961
hierarchy_top_title	Bangabandhu Sheikh Mujib Medical University Journal
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)635605961 (DE-600)2573885-9
title	Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis
ctrlnum	(DE-627)DOAJ09191289X (DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e
title_full	Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis
author_sort	Naomee Shareef
journal	Bangabandhu Sheikh Mujib Medical University Journal
journalStr	Bangabandhu Sheikh Mujib Medical University Journal
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2023
contenttype_str_mv	txt
author_browse	Naomee Shareef Ahmed Abu Saleh Abu Naser Ibne Sattar Shaheda Anwar
container_volume	16
format_se	Elektronische Aufsätze
author-letter	Naomee Shareef
doi_str_mv	10.3329/bsmmuj.v16i3.64496
author2-role	verfasserin
title_sort	isoniazid resistance profile in rifampicin resistant mycobacterium tuberculosis
title_auth	Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis
abstract	Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166
abstractGer	Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166
abstract_unstemmed	Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	3
title_short	Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis
url	https://doi.org/10.3329/bsmmuj.v16i3.64496 https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e https://banglajol.info/index.php/BSMMUJ/article/view/64496 https://doaj.org/toc/2074-2908 https://doaj.org/toc/2224-7750
remote_bool	true
author2	Ahmed Abu Saleh Abu Naser Ibne Sattar Shaheda Anwar
author2Str	Ahmed Abu Saleh Abu Naser Ibne Sattar Shaheda Anwar
ppnlink	635605961
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3329/bsmmuj.v16i3.64496
up_date	2024-07-03T22:59:25.671Z
_version_	1803600596222083072
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ09191289X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240414194212.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240412s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3329/bsmmuj.v16i3.64496</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ09191289X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ668c66c68ec44d1b9f8f36edba85b88e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Naomee Shareef</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem. Rifampicin (RIF) resistance has been used as a surrogate marker for MDR-TB but isoniazid (INH) resistance within RIF resistance cases is little known. This study aimed to determine the proportion of INH resistance among RIF-resistant MTB. Methods: In this cross-sectional study, from March 2021 to February 2022, 53 RIF-resistant MTB isolates in sputum samples detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes to detect INH resistance by real-time PCR. Statistical analysis was done using IBM SPSS (version 26). Results: Out of 53 RIF-resistant samples, 15.1% were sensitive to INH, and the rest had concomitant resistance to INH. The proportion of newly diagnosed and previously treated cases was nearly equal, and most of the previously treated cases (92.9%) received treatment regularly. INH-resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). KatG was found to be the prominent mutation, with or without in combination with inhA mutation. Conclusion: A considerable number of RIF-resistant isolates did not show concomitant resistance to INH. Most of the INH-resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high-dose INH will help to avoid dose-dependent toxicity in MDR-TB patients. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166 </subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MDR-TB, RIF resistance, INH resistance, katG, inhA</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ahmed Abu Saleh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abu Naser Ibne Sattar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shaheda Anwar</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Bangabandhu Sheikh Mujib Medical University Journal</subfield><subfield code="d">Bangabandhu Sheikh Mujib Medical University, 2017</subfield><subfield code="g">16(2023), 3</subfield><subfield code="w">(DE-627)635605961</subfield><subfield code="w">(DE-600)2573885-9</subfield><subfield code="x">22247750</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:16</subfield><subfield code="g">year:2023</subfield><subfield code="g">number:3</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3329/bsmmuj.v16i3.64496</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/668c66c68ec44d1b9f8f36edba85b88e</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://banglajol.info/index.php/BSMMUJ/article/view/64496</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2074-2908</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2224-7750</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">16</subfield><subfield code="j">2023</subfield><subfield code="e">3</subfield></datafield></record></collection>
score	7.4001083

Nicht das Richtige dabei?

Schreiben Sie uns!

Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?